A5015594944- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Cancer-related gene regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA regulation and disease
- Neonatal Health and Biochemistry
- Genetics and Neurodevelopmental Disorders
- Biomedical Research and Pathophysiology
- Advanced Chemical Sensor Technologies
- Skin and Cellular Biology Research
- Cutaneous Melanoma Detection and Management
- Congenital heart defects research
- Genetic and rare skin diseases.
- Amino Acid Enzymes and Metabolism
- Genomics and Chromatin Dynamics
- Yersinia bacterium, plague, ectoparasites research
- Heat shock proteins research
- Lipid metabolism and disorders
- Nicotinic Acetylcholine Receptors Study
- 3D Shape Modeling and Analysis
- Immune Cell Function and Interaction
- Mechanisms of cancer metastasis
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
Beijing Children’s Hospital
2015-2024
Capital Medical University
2015-2024
Hong Kong Baptist University
2023
Shangqiu Normal University
2018-2019
Shangqiu Institute of Technology
2018
Huaian First People’s Hospital
2015
Peking Union Medical College Hospital
2011-2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2013
In this study, we developed a novel and facile electrochemical aptasensor for β-amyloid (Aβ) oligomer detection based on metal–organic frameworks (MOFs) as signal probes.
This research investigates the preservation of Hong Kong’s traditional handicrafts, specifically porcelain paintings (Guangcai), through advanced computational modeling and Cave Automatic Virtual Environment (CAVE) systems. The study develops an interactive digital platform that transforms artistic expression into contemporary experiences by combining physics-based simulation, haptic feedback, immersive narratives within a Reality (VR) framework. methodology consists several critical...
To study the clinical features, genetic etiology, and correlation between phenotype genotype of neonatal diabetes mellitus (NDM) in Chinese patients.We reviewed medical records 25 NDM patients along with their follow-up details. Molecular analysis was performed. We compared HbA1c levels PNDM group infantile-onset T1DM patients.Of patients, 18 (72.0%) were 7 (28.0%) TNDM. Among cases, 6 (33.3%) had known KATP channel mutations (KATP-PNDM). There six non-KATP mutations, five novel including...
Congenital cataract is one of the leading causes human blindness. In this study, we identified a novel, heterozygous c.385G<T mutation in CRYGC that resulted substitution highly conserved glycine by cysteine at codon 129 (p.Gly129Cys) three-generation Chinese family with autosomal dominant congenital nuclear sequencing candidate genes. Using zebrafish as model, demonstrated γC-crystallin p.Gly129Cys mutant caused vacuole and incomplete denucleation lens, recapitulating phenotype beings....
Monocytes play important roles in antigen presentation and cytokine production to achieve a proper immune response, are therefore largely implicated the development progression of autoimmune diseases.The aim this study was analyze change intermediate (CD14+CD16+) monocyte subset children with recent-onset type 1 diabetes mellitus (T1DM) its possible association clinical parameters reflecting islet β-cell dysfunction.Compared age-and sex-matched healthy controls, monocytes were expanded T1DM,...
Abstract Background To evaluate the effectiveness of individualized-dose polyethylene glycol recombinant human growth hormone (PEG-rhGH) for short stature. Methods This real-world study enrolled children with stature in 19 hospitals throughout China. They were treated PEG-rhGH 6 months. The starting dosage ranged from 0.10 to 0.20 mg/kg/week. primary outcome was change height standard deviation score (ΔHt SDS). Results Five hundred and ten patients included grouped based on as A (0.10–0.14...
ABSTRACT Importance Octreotide is an off‐label medicine for congenital hyperinsulinism (CHI), but currently widely used treatment of patients with CHI. Thus far, variable efficacy and adverse effects have been reported octreotide. Objective The present study evaluated the safety a subcutaneous octreotide injection diazoxide‐unresponsive CHI in China. Methods This was retrospective review children who were treated injection. side assessed. Results Twenty‐five Chinese (15 boys) involved study....
Wolf-Hirschhorn syndrome is a well-characterized genomic disorder caused by 4p16.3 deletions. patients exhibit characteristic facial dysmorphism, growth retardation, developmental delay, intellectual disability and seizure disorders. Recently, NSD2 gene located within the 165 kb critical region was identified as key causal responsible for most if not all phenotypes of syndrome. So far, eight loss function variants have been reported in from different parts world, were de novo variants. In...
Objective: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is rare, manifestations of are diverse may be overlooked. We aimed to evaluate the incidence these manifestations. Methods: Patients ROHHAD syndrome reported before after 2019 were divided into Groups 1 2. who diagnosed at three regional hospitals in China included Group 3. collected age each specific term (neurogenic tumor, NET) acronym detailed term, compared them among...
Objective: There is a notable absence of extensive Chinese studies involving monogenic congenital hyperinsulinism (CHI). The purpose this large retrospective cohort with CHI from national children’s medical center was to analyze the genetic and clinical characteristics. Methods: We compared characteristics grouped by genotypes based on CHI‐targeted next‐generation sequencing (tNGS) performed subgroup analyses onset time. Results: Totally, 121 non‐consanguineous patients were enrolled. Among...
As a rare autosomal-recessive metabolic disorder, cystinosis is caused by defective transport of cystine across the lysosomal membrane.[1] Once diagnosis confirmed, specific treatment with cysteamine, an aminothiol, should be applied to patient as soon possible in order preserve renal function and improve growth affected children.[2] Cysteamine only drug approved Food Drug Administration for cystinosis. Although it cannot reverse existing kidney damage, was reported that 17 patients treated...
Background Cystinosis is a rare autosomal-recessive disorder caused by defective transport of cystine across the lysosomal membrane. Previous studies have mapped cystinosis to CTNS gene which located on chromosome 17p13, and various mutations been identified correlate them with this disease. Methods We analyzed six patients from five unrelated families who were diagnosed in our hospital. described diagnostic procedures for all proposed alternative therapies instead using cysteamine, an...
The purpose of this study was to determine the frequency maturity-onset diabetes young (MODY) in two selected cohorts Chinese children with and clinically suspected MODY, using next-generation sequencing (NGS). Ninety-three who met comprehensive criteria MODY were enrolled cohorts. A custom NGS panel or a whole exon group used for sequencing. We identified 55/93 (59.1%) pathogenic likely variants. Forty-two (76.3%) confirmed have GCK (MODY2) mutation. Additionally, five had HNF1A (MODY3),...
Objective To study the effect of ultrasound guided curettage after methotrexate and mifepristone in treatment endogenous caesarean scar pregnancy. Methods A retrospective analysis was performed on 43 patients pregnancy undergoing mifepristone. Results 39 cases were successful, 4 transformed to laparotomy because intraoperative blood loss, 7 bleeding successful by uterine carity placed double lumina Foley catheter. Conclusion Ultrasound is a safe, effective, little trauma...
This paper discusses how printmaking methods can be used as a methodology to re-examine and analyse works in the field of digital media. It presents history theory from Chinese perspective investigates relationship between unique indirect creation mode system, data transfer transcoding media.
 proposes that lead better understanding images. First, defines functions its image. Second, it analyses image applied media form an equivalence file Finally, this uses printmaker Chen Qi case...