A5053366280- Epigenetics and DNA Methylation
- Congenital heart defects research
- Heavy Metal Exposure and Toxicity
- Selenium in Biological Systems
- MicroRNA in disease regulation
- RNA modifications and cancer
- Connexins and lens biology
- Trace Elements in Health
- Histone Deacetylase Inhibitors Research
- Congenital Heart Disease Studies
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Second Language Acquisition and Learning
- Arsenic contamination and mitigation
- Immune cells in cancer
- Metabolism, Diabetes, and Cancer
- Reproductive System and Pregnancy
- Aldose Reductase and Taurine
- Biochemical effects in animals
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Natural Language Processing Techniques
Guangxi Medical University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Guangxi University
2007-2024
Peking Union Medical College Hospital
2011-2022
Taizhou First People's Hospital
2015-2021
Guigang City People's Hospital
2021
Chinese National Human Genome Center
2006-2019
Tianjin Municipal Research Institute for Family Planning
2008-2019
National Health and Family Planning Commission
2007-2018
Victoria University of Wellington
2017-2018
Selenoprotein K (SelK) is a newly identified selenoprotein. We showed that selenium incorporation into SelK was dependent on the 3′UTR of mRNA. Sec insertion sequence (SECIS) RNA binding assays demonstrated human SBP2 bound to SECIS element through conserved non‐Watson–Crick base pair quartet but not AAT motif. Examination expression pattern revealed mRNA highly expressed in heart. Immunofluorescence analysis localized endoplasmic reticulum. Using recombinant adenovirus, we found...
<i>Background:</i> Quercetin is a flavonoid found ubiquitously in nature. Studies vitroand vivohave suggested that quercetin may have protective role against colon cancer. <i>Methods:</i> We selected the human cancer cell line RKO to investigate effects of vitro. cells were treated with different concentrations quercetin. <i>Results:</i> In comparison control, was able inhibit growth cells, as measured using...
Excessive manganese exposure induced cognitive deficit. Several lines of evidence have demonstrated that taurine improves impairment by numerous neurotoxins. However, the role on manganese-induced damages in learning and memory is still elusive. This goal this study was to investigate beneficial effect capacity an animal model. The escape latency Morris Water Maze test significantly longer rats injected with than received both manganese. Similarly, probe trial showed annulus crossings were...
The excessive M1 polarization of macrophages drives the occurrence and development inflammatory diseases. reprogramming from to M2 can be achieved by targeting metabolic events. Taurine promotes for balance energy metabolism repair injury, preventing chronic diseases complications. However, little is known about mechanisms underlying action taurine modulating macrophage phenotype. In this study, we constructed a low-dose LPS/IFN-γ-induced model simulate low-grade pro-inflammatory process....
Abstract Inorganic arsenic, an environmental contaminant, is known to cause cancer, developmental retardation, and many other serious diseases. Previous researches have shown that arsenic exerts its toxicity partially through generating reactive oxygen species (ROS). However, it still not well understood how ROS links exposure retardation of preimplantation embryo. Here we demonstrate high‐level arsenite induces severe redox imbalance by decreasing the levels glutathione increasing oxidative...
Congenital cataract is one of the leading causes human blindness. In this study, we identified a novel, heterozygous c.385G<T mutation in CRYGC that resulted substitution highly conserved glycine by cysteine at codon 129 (p.Gly129Cys) three-generation Chinese family with autosomal dominant congenital nuclear sequencing candidate genes. Using zebrafish as model, demonstrated γC-crystallin p.Gly129Cys mutant caused vacuole and incomplete denucleation lens, recapitulating phenotype beings....
Abstract As a nutritional factor, folic acid can prevent cardiac and neural defects during embryo development. Our previous study showed that arsenic impairs development by down-regulating Dvr1/GDF1 expression in zebrafish. Here, we investigated whether could protect against arsenic-mediated toxicity. We found supplementation increases hatching survival rates, decreases malformation rate ameliorates abnormal of zebrafish embryos exposed to arsenite. Both real-time PCR analysis whole in-mount...
MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through direct targeting oncogenes or tumor suppressors. It has previously suggested that miR‑126 may be associated with endometrial cancer (EC). However, exact role migration invasion EC cells not yet studied. The present study expression was significantly decreased tissues when compared matched normal adjacent tissues. current reverse transcription-quantitative...
Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder characterized by retrograde axonal degeneration that primarily affects long spinal neurons. The gene encoding spastin has well-established association with HSP, and protrudin known binding partner of spastin. Here, we demonstrate the N-terminal domain mediates interaction spastin, which responsible for neurite outgrowth. We show promotes protrudin-dependent outgrowth in PC12 cells. To further confirm these physiological...
Abstract A novel and simple method to form water‐dispersed magnetic nanoparticles was successfully developed through glucosaminic acid‐surface modification of iron oxide nanoparticles. The resultant acid‐modified (GA‐MNPs) had not only good uniformity in spherical shape with diameter about 10–13 nm, but also possessed excellent water‐dispersity stability. In cell culture experiments, the internalization GA‐MNPs into different kinds cells observed over a 5‐day period. results indicated that...