A5071199224- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Epigenetics and DNA Methylation
- Genomics and Rare Diseases
- Glutathione Transferases and Polymorphisms
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Head and Neck Surgical Oncology
- Facial Trauma and Fracture Management
- Hair Growth and Disorders
- Molecular Biology Techniques and Applications
- Temporomandibular Joint Disorders
- Histone Deacetylase Inhibitors Research
- Medical and Biological Sciences
- Wound Healing and Treatments
- Congenital Ear and Nasal Anomalies
- Ocular Disorders and Treatments
- Congenital heart defects research
- Electrospun Nanofibers in Biomedical Applications
Shanghai Jiao Tong University
2017-2021
Shanghai Ninth People's Hospital
2017-2021
National Natural Science Foundation of China
2017
National Health and Family Planning Commission
2007
Abstract Bone has a remarkable potential for self-healing and repair, yet several injury types are non-healing even after surgical or non-surgical treatment. Regenerative therapies that induce bone repair improve the rate of recovery being intensely investigated. Here, we probed marrow stem cells (BMSCs) engineered with chemically modified mRNAs (modRNA) encoding hBMP-2 VEGF-A gene to therapeutically heal bone. Induction osteogenesis from modRNA-treated BMSCs was confirmed by expression...
Saethre-Chotzen syndrome is an autosomal dominantly inherited disorder caused by mutations in the twist family basic helix-loop-helix transcription factor 1 (TWIST1) gene. Surgical procedures are frequently required to reduce morphological and functional defects patients with syndrome. Therefore, development of noninvasive treat critical. We identified that periostin, which extracellular matrix protein plays important role both bone connective tissues, downregulated craniosynostosis...
Craniosynostosis is one of the most common craniofacial abnormalities. It involves premature closure or more cranial sutures. Mutations in many genes have been and continue to be identified patients.Whole blood samples were collected from patient family members.Whole exome sequencing was performed identify potential mutations patient. The results verified by Sanger comparing SPECC1L gene sequence 100 unrelated population-matched controls.The presented with craniosynostosis fusion bicoronal...
Congenital maxillomandibular syngnathia is an extremely rare disorder characterized by craniofacial malformations and inability to open the mouth adequately, which leads problems with feeding, swallowing, breathing as well temporomandibular joint ankylosis. The main goal of surgery release ankylosis, establish functioning mandible, prevent re-fusion. However, surgical procedures for this disease are rarely reported.Here, we report a 7-mo-old girl bilateral syngnathia. patient presented...
目的 探讨硫化镉量子点(CdS quantum dots,CdS QDs)对中国仓鼠肺成纤维细胞(CHL)的毒性作用及其可能的作用机制.方法 实验设2.5、5.0、10.0、20.0、50.0、100.0μg/ml CdS QDs(乳化膜法合成)6个剂量组作用于CHL细胞,对照组予等量的生理盐水.用荧光倒置显微镜观察细胞的形态学变化,噻唑蓝(MTT)法检测CdS QDs对CHL细胞增殖的抑制作用.CHL细胞分别暴露于不同浓度的CdS QDs 24 h后.测定细胞内乳酸脱氢酶(LDH)释放率及丙二醛(MDA)、谷胱甘肽(GSH)含量.结果 QDs染毒24 h后,细胞变形、收缩,胞体折光性脆弱.随着CdS QDs染毒剂量的增加,CHL细胞存活率逐渐下降,且各剂量组间与对照组相比,差异均有统计学意义(P<0.05或P<0.01).CdS h后,随染毒剂鼍的增加,各剂量组细胞LDH释放率均明显上升,差异有统计学意义(P<0.01).20.0、50.0μg/ml...
To explore a new accurate way for the treatment of congenital midfacial dysplasia in facial cleft patients.Between November 2015 and 2016, 8 patients with nasal deformity (Tessier Nos. 3-11 cleft) were collected (median age, years; range = 15-20 years). Expanded frontal flap reconstruction image-guided navigation-assisted surgery modified nasal-maxillary-hard palatine osteotomy to advance peri-pyriform bone structure performed all patients. After 6 12 months follow-up, authors analyzed...
Objective To evaluate the etiology, therapeutic approaches and prognosis of orbital hypertelorism. Methods Clinical data 23 cases were summarized with review ot literature. Results All operations provided satisfactory cosmetic effects. All patients followed up for 6 months to 5 years, no recurrence observed. Conclusions A good effect can be obtained by operation in The preschool period best opportunity, stable effects could gotten psychological development children has...
Objective To investigate the contouring plastic effect of digital navigation techniques assisted mandibular angle osteotomy, thereby providing surgical reference and evaluation basis for improving accuracy, efficacy safety surgery. Methods From March 2015 to 2017, 15 female cases aided intral-oral osteotomy in past 2 years were collected compared pre-operational image design. Results The postoperative navigation-assisted was well matched that preoperative The smooth bilateral...
Hair follicle stem cells are pluripotent and have a self‑renewal capacity multi‑differentiation potential <em>in vitro</em>. As hair can be easily sampled from the skin of clinical patients at considerable quantity, these applications in wound repair tissue engineering. Effective approaches for vitro</em> culture amplification mouse cells, as well osteogenic differentiation cell source when obtaining mouse‑separated were examined. Serial subculture was performed different systems. Cell...