A5014475550- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Facial Trauma and Fracture Management
- Facial Rejuvenation and Surgery Techniques
- Nasal Surgery and Airway Studies
- Reconstructive Facial Surgery Techniques
- Orthodontics and Dentofacial Orthopedics
- Orthoptera Research and Taxonomy
- Medical and Biological Sciences
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Temporomandibular Joint Disorders
- Scarabaeidae Beetle Taxonomy and Biogeography
- Tracheal and airway disorders
- Anatomy and Medical Technology
- Electrospun Nanofibers in Biomedical Applications
- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- CRISPR and Genetic Engineering
- Genetic diversity and population structure
- DNA Repair Mechanisms
- Bone Tumor Diagnosis and Treatments
- Wound Healing and Treatments
- Fossil Insects in Amber
Shanghai Jiao Tong University
2011-2024
Shanghai Ninth People's Hospital
2010-2024
East China Normal University
2022-2024
Qingdao Agricultural University
2024
Beijing Institute of Technology
2023
Beijing Jiaotong University
2021-2022
University of California, Davis
2022
Shaoxing People's Hospital
2021
National Natural Science Foundation of China
2017
Sheng Jing Hospital
2015
Abstract Bone has a remarkable potential for self-healing and repair, yet several injury types are non-healing even after surgical or non-surgical treatment. Regenerative therapies that induce bone repair improve the rate of recovery being intensely investigated. Here, we probed marrow stem cells (BMSCs) engineered with chemically modified mRNAs (modRNA) encoding hBMP-2 VEGF-A gene to therapeutically heal bone. Induction osteogenesis from modRNA-treated BMSCs was confirmed by expression...
Ischemia-reperfusion (I/R) injury leads to a low success rate of skin flap transplantation in reconstruction surgery, thus requiring development new treatments. Necroptosis and apoptosis pathways, along with overexpression reactive oxygen species pro-inflammatory factors transplantation, are deemed as potential therapeutic targets. This study provides paradigm for nanozyme-mediated microenvironment maintenance improve the survival transplanted flap. Prussian blue nanozyme (PBzyme) multiple...
Abstract Background The prevalence of osteoarthritis (OA) is increasing, yet clinically effective and economical treatments are unavailable. We have previously proposed a cell-free fat extract (CEFFE) containing multiple cytokines, which possessed antiapoptotic, anti-oxidative, proliferation promotion functions, as “cell-free” strategy. In this study, we aimed to evaluate the therapeutic effect CEFFE in vivo vitro. Methods sodium iodoacetate-induced OA rats were treated with by...
Transplantation of adipose-derived stem cells (ASCs) is a promising option in the field chronic wounds treatment. However, effectiveness ASCs therapies has been hampered by highly inflammatory environment wound areas. These problems could be partially circumvented using efficient approaches that boost survival and anti-inflammatory capacity transplanted ASCs. Here, application mechanical stretch (MS), we show exhibits increased immunoregulatory properties vitro. MS triggers secretion...
Abstract Background Craniomaxillofacial bone defects are currently reconstructed by using computer‐aided design and manufacturing (CAD/CAM) processes. We have developed a novel digital medical support system that enables us to custom‐make scaffolds repair craniomaxillofacial three‐dimensional computed tomographic (CT) images rapid‐prototyping method. Methods created positive molds CT data, CAD/CAM rapid prototyping method 3D printing. Custom‐made poly (glycolic acid) (PGA) polymers (lactic...
To establish a new method of presurgical nasoalveolar molding (NAM) using computer-aided reverse engineering and rapid prototyping technique in infants with unilateral cleft lip palate (UCLP).Five (2 males 3 females mean age 1.2 w) complete UCLP were recruited. All patients subjected to NAM before the repair. The upper denture casts recorded three-dimensional laser scanner within 2 weeks after birth infants. A digital model was constructed analyzed simulate procedure software. geometrical...
Tissue expansion techniques play an important role in plastic surgery. How to improve the quality of expanded skin and shorten period are still worth investigating. Our previous studies found that a cell-free fat extract (CEFFE) possessed pro-angiogenic pro-proliferative activities. However, CEFFE on tissue has remained unclear. The purpose this study was evaluate effect expansion.A rat model used. Animals were treated with by subcutaneous injection. After 4 weeks expansion, necrosis...
Class switch recombination generates distinct antibody isotypes critical to a robust adaptive immune system, and defects are associated with autoimmune disorders lymphomagenesis. Transcription is required during class recruit the cytidine deaminase AID-an essential step for formation of DNA double-strand breaks-and strongly induces R loops within immunoglobulin heavy-chain locus. However, impact on break repair remains unclear. Here, we report that cells lacking two enzymes involved in loop...
The aim of the study was to find a proper method that may evaluate severity facial asymmetry quickly and accessibly in clinics. Methods: three-dimensional image data patients were collected with laser surface scanning, desired therapy outcomes simulated computers by flip-registration procedure. discrepancy between results initial images calculated automatically, colored hypsography printed. A questionnaire given both patient craniofacial surgeon examine symmetry, accessibility,...
Le Fort III osteotomy with midface distraction osteogenesis (Le DO) can improve the form and change upper airway space. Some surgeons believe that advancement respiratory outcome dramatically, but others think it does not predictably result in cure of obstructive sleep apnea (OSA). In this study, we evaluated structural functional changes before after DO; hope these studies future protocols for advancement. A retrospective study 11 patients severe retrusion who underwent external distractor...
Objective: The zygomatic body and arch are usually prominent in Asians; therefore, malar reduction is one of the most popular procedures for aesthetic facial contouring. purpose this study was to establish a new option malarplasty analyze merits demerits conventional operative techniques, thus searched more effective reliable surgical procedures. Methods: Records 570 patients who underwent our center from 1988 2008 were reviewed study. Several introduced techniques used until an alternative...
Objective: To explore the application prospects of EH compound artificial bone material combined with computerized three-dimensional reconstruction in craniomaxillofacial surgery. Methods: Computed tomographic scan, computer-aided design/computer-aided manufacturing reconstruction, and rapid prototyping were conducted on 39 patients during 2005 to 2008. An was made into exact geometric shapes defect be corrected then implanted surgical reconstruction. Results: The implants perfectly matched...
An increasing number of transgender females are suffering from a critical gender dysphoria, which often presents as depression and self-destructive behavior. Facial feminization surgery (FFS) is an effective method to alleviate symptoms could be more important than genital reassignment for Chinese. contour perceived ordinary FFS the Chinese women improve their facial appearance. The zygoma jaw key areas feminizing contour. This study mainly emphasized necessity discussed importance...
Early warning prediction of traumatic hemorrhagic shock (THS) can greatly reduce patient mortality and morbidity. We aimed to develop validate models with different stepped feature sets predict THS in advance. From the PLA General Hospital Emergency Rescue Database Medical Information Mart for Intensive Care III, we identified 604 1,614 patients, respectively. Two popular machine learning algorithms (i.e., extreme gradient boosting [XGBoost] logistic regression) were applied. The area under...
Classification and diagnosis of congenital craniofacial cleft deformities are helpful in discerning the severity deformity providing guidance for surgical repair. Eighty-one cases were analyzed using Tessier classification. Depending on location, status deformity, results examinations such as computed tomography, according to range affected, location designated by STO classification, with S skin, T soft tissue, O os (craniofacial bone). The is delineated Arabic numerals. analysis 81...
The repair of fronto-orbital nasal bone defects may be a troublesome problem to plastic surgeons. This report aims present the results reconstruction with prefabrication epoxied maleic acrylate/hydroxyapatite compound (EH compound) using 3-dimensional (3D) imaging data and computer-assisted manufacturing techniques, sometimes combined autogenous defect. Helical computed tomography were used create 3D model patient's skull. On basis these data, individual shape implant was created by...
Abstract Assessment of skin lymphatic vessels is great significance in understanding their roles many pathological conditions. Our aim was to identify the optimal approach for investigation cutaneous system. We performed comparative studies on using immunohistochemistry tissue sections, computer graphic reconstruction method together with immunohistochemically stained serial sections and whole mount fluorescence human lower limb. Lymphatic were identified podoplanin antibody. The relative...
Objective: To summarize and analyze the postoperative complications of box-shift osteotomy performed at our center for Chinese orbital hypertelorism patients from 2008 to 2017. Method: This retrospective study reviews records 78 with complete medical least 2 years follow-up data. Both radiologic anthropometric assessments were conducted before, 1 month after surgery evaluate bony soft-tissue alterations. Postoperative recorded during hospitalization each visit divided into 3 groups: acute...