A5072661521- Wound Healing and Treatments
- S100 Proteins and Annexins
- Dermatologic Treatments and Research
- Osteoarthritis Treatment and Mechanisms
- Bee Products Chemical Analysis
- Advancements in Transdermal Drug Delivery
- Tendon Structure and Treatment
- Acute Kidney Injury Research
- Protease and Inhibitor Mechanisms
- interferon and immune responses
- Pelvic floor disorders treatments
- Neonatal Respiratory Health Research
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Photodynamic Therapy Research Studies
- Nerve injury and regeneration
- melanin and skin pigmentation
- Periodontal Regeneration and Treatments
- Skin Protection and Aging
- Hair Growth and Disorders
- Body Contouring and Surgery
- Fatty Acid Research and Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
Shanghai Jiao Tong University
2021-2024
Shanghai Ninth People's Hospital
2023
Shanghai Cancer Institute
2023
State Key Laboratory of Oncogene and Related Genes
2023
Renji Hospital
2023
Existing clinical treatments for tendinopathy mainly focus on reducing pain, whereas inhibiting or reversing disease progression remains challenging. Local therapeutic drugs, such as glucocorticoids, cause adverse effects the metabolism of tendon tissues and injection-related complications. Therefore, new administration modalities need to be developed. In this study, we designed a hydrogel-based microneedle (MN) system long-term transdermal delivery our novel biological cell-free fat extract...
Abstract Background The prevalence of osteoarthritis (OA) is increasing, yet clinically effective and economical treatments are unavailable. We have previously proposed a cell-free fat extract (CEFFE) containing multiple cytokines, which possessed antiapoptotic, anti-oxidative, proliferation promotion functions, as “cell-free” strategy. In this study, we aimed to evaluate the therapeutic effect CEFFE in vivo vitro. Methods sodium iodoacetate-induced OA rats were treated with by...
Androgenetic alopecia (AGA) is one of the most common hair loss diseases worldwide. However, current treatments including medicine, surgery, and stem cells are limited for various reasons. Cell-free fat extract (CEFFE), contains cell factors, may have potential abilities in treating AGA. This study aims to evaluate safety, effectiveness underlying mechanism CEFFE AGA.Sex hormone evaluation, immunogenicity assay genotoxicity were conducted CEFFE. In vivo study, male C57BL/6 mice injected...
One of the key obstacles to healing diabetic wound is persistence active inflammation. We previously demonstrated potential cell-free fat extract (CEFFE) promote wounds, and annexin A5 (A5) a crucial anti-inflammatory protein within CEFFE. This study aimed evaluate therapeutic in wounds. was loaded into GelMA hydrogels applied skin wounds mice vivo. The with treatment GelMA-A5 were observed for 14 days evaluated by histological analysis. Accessment inflammation regulation conducted through...
Osteoarthritis (OA) is a challenging degenerative joint disease to manage. Previous research has indicated that cell-free fat extract (CEFFE) may hold potential for OA treatment. This study investigated the role of Annexin A5 (AnxA5) within CEFFE in regulating macrophage polarization and protecting chondrocytes.
Most perimenopausal and postmenopausal women experience estrogen deficiency-induced vaginal atrophy. However, replacement therapy has contraindications side effects, which makes it unsuitable for most women. Cell-free fat extract (CEFFE) pro-proliferative proangiogenic tissue regeneration activities.The purpose of this study was to evaluate the effect topical application CEFFE in vagina on keratinocytes.Ovariectomized mice were treated with via 2 weeks. The mucosal cell layer number,...
ABSTRACT Background and Objective CEFFE (Cell‐free fat extract) treatment for periocular fine lines requires thorough clinical evaluation to determine its efficacy safety in enhancing skin quality. The research enrolled 10 healthy female participants aged 31–58, focusing on texture, elasticity, barrier function. Methods Results demonstrated significant benefits, with notable improvements observed as early 3 months posttreatment, which continued throughout the 12‐month follow‐up period....
Abstract Background: Renal ischemia-reperfusion injury (IRI) is one of the causes acute kidney injury. Annexin A5 (AnxA5) as a calcium-dependent cell membrane binding protein has shown good protective effects in various organ IRI models. This study explored therapeutic effect exogenous AnxA5 monomer on renal and its potential mechanism. Methods: In vivo, different doses were injected intravenously to treat bilateral models SD rats. model confirms structure function kidneys. vitro, HK-2,...
Current treatment modalities for postinflammatory hyperpigmentation (PIH) often fall short in delivering satisfactory results some patients. Therefore, this study aimed to assess the efficacy and tolerability of autologous cell‐free fat extract (CEFFE) PIH. We enrolled 15 patients with PIH administered them five intracutaneous CEFFE injections, each at a two‐week interval. Evaluation included assessment using objective (standard two‐dimensional photos, VISIA®‐photos, brown spot (BS) index,...
Pancreatic cancer is a malignant disease with an extremely poor prognosis. For now, radical resection the only long-term survival approach. Therefore, for complete of different types pancreatic neoplasms, scholars and surgeons have innovated applied numerous surgical methods. Aiming at various situations, large amout methods principles been suggested. Unresectable neoplasms challenged day by day. Meanwhile, progression technology, minimally invasive techniques to neoplasms. This article...
Abstract Background: The prevalence of osteoarthritis (OA) is increasing, yet clinically effective and economical treatments are unavailable. We have previously proposed a cell-free fat extract (CEFFE) containing multiple cytokines, which possessed anti-apoptotic, anti-oxidative, proliferation promotion functions, as “cell-free” strategy. In this study, we aimed to evaluate the therapeutic effect CEFFE in vivo vitro . Methods: sodium iodoacetate-induced OA rats were treated with by...
Existing clinical treatments for tendinopathy mainly focus on reducing pain, while inhibition or reversion of disease progression remains challenging. local therapeutic drugs, such as glucocorticoids, not only have adverse effect the metabolism tendon tissue, but also cause injection-related complications. So new administration modalities need to be developed. Therefore, we designed a hydrogels-based microneedles (MNs) system long-term transdermal delivery our novel biological cell-free fat...