A5100715235- Connexins and lens biology
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- RNA modifications and cancer
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Cardiac Fibrosis and Remodeling
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Yersinia bacterium, plague, ectoparasites research
- Heme Oxygenase-1 and Carbon Monoxide
- Nuclear Receptors and Signaling
- Cardiovascular Function and Risk Factors
- Ginkgo biloba and Cashew Applications
- Neurological diseases and metabolism
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- Gestational Diabetes Research and Management
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Intraocular Surgery and Lenses
- Mechanisms of cancer metastasis
Yuhuangding Hospital
2016-2025
Qingdao University
2016-2025
North Sichuan Medical University
2019-2025
Beijing Technology and Business University
2024
First Affiliated Hospital of Xinjiang Medical University
2023-2024
Xinjiang Medical University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Academy of Medical Sciences
2024
National Health and Family Planning Commission
2023
First Affiliated Hospital of Zhengzhou University
2022-2023
Abstract Background Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, current medical methods have limited therapeutic effects. The present study aimed to find out molecular mechanism AKI pathogenesis, may provide new insights for future therapy. Methods Bioinformatic analysis was conducted using R language (AT&T BellLaboratories, University Auckland, New Zealand) acquire differentially expressed long noncoding RNAs (lncRNAs) and...
Abstract Background Pre-eclampsia (PE) is regarded as the leading cause of maternal and neonatal morbidity mortality. Nevertheless, potential mechanism for regulation trophoblast behaviors pathogenesis PE remain largely elusive. Recently, accumulating evidence emphasized that aberrant expression long non-coding RNAs (lncRNAs) functions imperative regulators in human diseases, including PE. Thus, identifying PE-related specific lncRNAs to uncover underlying molecular much significance....
To design a multi-epitope assembly peptide (MEP) of Acinetobacter baumannii and evaluate its immunogenicity protective immunity in Balb/c mice.The T- B-cell epitopes outer membrane proteins FilF NucAb from A. were predicted identified by using bioinformatics software immunological tests. Peptides with high adhesin probability Ata protein was used as the backbone, two one CD4+ T-cell epitope linked to N-terminal C-terminal backbone construct MEP. The gene MEP expressed E. coli BL21, efficacy...
Being clinically diagnosed with a mild cognitive impairment (MCI) due to Alzheimer's disease (AD) is widely studied. Yet, the clinical and structural neuroimaging characteristics for prodromal AD, which are defined as A+T+MCI based on AT (N) system still highly desirable. This study evaluates differences of assessments magnetic resonance imaging (MRI) between early MCI (EMCI) late (LMCI) participants system. The potential value MRI predictor decline during follow-up in AD further...
Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis unclear. This article aims to investigate the role of ROCK1 in apoptosis lens epithelial cells (LECs) age-related cataracts.We collect anterior capsule samples from normal people, patients with cataracts, young mice naturally aging mice. The oxidative stress-induced model was constructed by cultivating HLE-B3 H2O2. MTT, Hoechst 33342, TUNEL assay were performed explore proliferation apoptosis. HE used...
Stem cell transplantation has brought new hope for the treatment of neurological diseases. The key to stem therapy lies in inducing specific differentiation cells into nerve cells. Because vitro and vivo is affected by multiple factors, final outcome strongly associated with microenvironment which are located. Accordingly, optimal a hot topic. EGb761 extracted from leaves Ginkgo biloba tree. It used worldwide becoming one focuses research. Studies have shown that can antagonize oxygen free...
Long non-coding RNA plasmacytoma variant translocation 1 (PVT1) has been revealed to involve in the progression of CRC. However, precise mechanisms PVT1 action remain unclear.The expression PVT1, microRNA-106b-5p (miR-106b-5p) and four jointed box (FJX1) was measured using quantitative real-time polymerase chain reaction (qRT-PCR) or Western blot, respectively. Cell proliferation investigated by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide assay. Transwell assay used...
Abstract Rationale: Congenital internal carotid artery hypoplasia (CICAH) is rarely reported. This study aimed to discuss the epidemiological characteristics, clinical manifestation, imaging and treatment of CICAH. Patient concerns: The case was male who showed barylalia limited abilities left limbs as their main manifestation. patient diagnosed CICAH by digital subtraction angiography (DSA) computed tomography (CT). Diagnosis: Interventions: underwent anti platelet aggregation,...