A5101787874- Bioinformatics and Genomic Networks
- Connexins and lens biology
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Flavonoids in Medical Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Saffron Plant Research Studies
- Medicinal Plants and Bioactive Compounds
- Advanced Glycation End Products research
- Hippo pathway signaling and YAP/TAZ
- Chronic Kidney Disease and Diabetes
- Yersinia bacterium, plague, ectoparasites research
- Biofuel production and bioconversion
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Advanced Photocatalysis Techniques
- Berberine and alkaloids research
- Cell death mechanisms and regulation
- Gene Regulatory Network Analysis
- Covalent Organic Framework Applications
- Genetics, Aging, and Longevity in Model Organisms
- Drug Transport and Resistance Mechanisms
- Heat shock proteins research
Mudanjiang Medical University
2017-2025
Harbin Medical University
2024
China Pharmaceutical University
2016-2019
China Medical University
2019
Central South University
2019
Shenyang Pharmaceutical University
2019
State Key Laboratory of Natural Medicine
2016-2018
Johns Hopkins University
2017-2018
Sidney Kimmel Comprehensive Cancer Center
2017-2018
University of Baltimore
2017
Noble-metal-free NiFeMo has been applied as an efficient catalyst for the rapid and complete decomposition of hydrous hydrazine hydrogen generation.
DNA methylation is known to be associated with cataracts. In this study, we used a mouse model and performed transcriptome sequencing analyses find epigenetic indicators for age-related cataracts (ARC). Anterior lens capsule membrane tissues from young aged mice were analyzed by MethylRAD-seq detect the genome-wide of extracted DNA. The had 76,524 15,608 differentially methylated CCGG CCWGG sites, respectively. Pearson correlation analysis detected 109 33 expressed genes (DEGs) negative at...
Targeted therapies specifically act by blocking the activity of proteins that are encoded genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding time course molecular changes responsible development acquired could enable optimization patients' treatment options. Clinically, therapeutic can only be studied at a single point in resistant tumors. To determine dynamics these changes, we obtained high throughput...
Hirsutella sinensis (HS) is the anamorph of traditional Chinese medicine Cordyceps . Although renal protective effect HS has been reported, its on diabetic nephropathy (DN) remains unclear. In this study, db/db mice were used as DN model, and was evaluated after oral administration for 6 12 weeks. Plasma, urine, kidney samples collected, biochemical indicator measurements, pathological analysis, metabolomics studies performed. Biochemical assays showed that reduced levels fasting blood...
Abstract BACKGROUND Targeted therapies specifically act by blocking the activity of proteins that are encoded genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding time course molecular changes responsible development acquired could enable optimization patients’ treatment options. Clinically, therapeutic can only be studied at a single point in resistant tumors. To determine dynamics these changes, we...
Berberrubine (BRB) has a strong lipid-lowering effect and can be extensively metabolized into berberrubine-9-<i>O</i>-<i>β</i>-d-glucuronide (BRBG) in vivo. Recently, pharmacokinetics studies showed that the production of BRBG was significantly decreased urine mice fed with high-fat diet (HFD), indicating glucuronidation capacity. Based on UDP-glucuronosyltransferase (UGT) isoform identification, hepatic renal microsomal incubation, examined to suggest metabolism BRB liver kidneys. The...
Cancers are known to be associated with accelerated aging, but date, there has been a paucity of systematic and in‐depth studies the correlation between aging cancer. DNA methylation ( m) profiles can used as markers utilized construct predictors. In this study, we downloaded 333 paired samples m, expression mutation encompassing 11 types tissues from The Cancer Genome Atlas public access portal. m scores were calculated using Support Vector Machine regression model. cancers revealed...
Abstract The current study performs time course RNA-seq and DNA methylation profiling to determine the complex interactions between gene expression epigenetic changes in acquired therapeutic resistance. genomics era provides widespread characterization of genomic landscape tumors has enabled precision treatment strategies. Currently, epidermal growth factor receptor (EGFR) inhibitors are only FDA-approved targeted therapy for clinical use head neck squamous cell carcinoma (HNSCC). EGFR...