A5070730032- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- Nanopore and Nanochannel Transport Studies
- Pharmacological Effects of Natural Compounds
- Glioma Diagnosis and Treatment
- Biosensors and Analytical Detection
- Analytical Chemistry and Chromatography
- Advanced Battery Materials and Technologies
- Molecular Sensors and Ion Detection
- Advancements in Battery Materials
- DNA and Biological Computing
- Ginseng Biological Effects and Applications
- Lipid Membrane Structure and Behavior
- Antibiotics Pharmacokinetics and Efficacy
- Meningioma and schwannoma management
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Advanced Biosensing Techniques and Applications
- Natural product bioactivities and synthesis
- Analytical chemistry methods development
- Electrochemical sensors and biosensors
- Advanced Battery Technologies Research
State Key Laboratory of Chemobiosensing and Chemometrics
2018-2024
Hunan University
2018-2024
Sun Yat-sen University
2023-2024
Sun Yat-sen University Cancer Center
2023-2024
Nantong University
2008-2024
Jilin Medical University
2024
Jilin University
2024
Zhejiang Cancer Hospital
2024
Chinese Academy of Sciences
2024
Nanjing University of Science and Technology
2018-2024
Sodium transition metal oxides with layered structures are attractive cathode materials for sodium-ion batteries due to their large theoretical specific capacities. However, these suffer from poor cyclability and low rate performance because of structural instability sluggish electrode kinetics. In the present work, we show sodiation reaction Mn3O4 yield crystal water free NaMnO2-y-δ(OH)2y, a monoclinic polymorph sodium birnessite bearing Na/Mn(OH)8 hexahedra Na/MnO6 octahedra. With new...
Drug resistance is a major obstacle to the efficient therapy of drug-resistant cancer. To overcome this problem, we constructed multifunctional DNA origami-based nanocarrier for codelivery chemotherapeutic drug (doxorubicin, Dox) and two different antisense oligonucleotides (ASOs; B-cell lymphoma 2 (Bcl2) P-glycoprotein (P-gp)) into cancer cells enhanced therapy. increase targeting ability origami, staple strands with 5'-end extended MUC1 sequences were used in preparation...
Sensitive tumor imaging and precise therapy play critical roles in cancer combat.
The enzymatic amplification strategy in living cells faces challenges of highly efficient intracellular codelivery reagents including DNA polymerase. In this work, we develop biomineralized metal-organic framework nanoparticles (MOF NPs) as a carrier system for ϕ29 polymerase (ϕ29DP) and nucleic acid probes realize polymerization reaction cells. A pH-sensitive biodegradable MOF NP zeolitic imidazolate framework-8 (ZIF-8) is utilized to encapsulate ϕ29DP adsorb probes. After uptake into...
Using an<italic>in vivo</italic>hybridization chain reaction with a tripartite DNA probe to image RNA in living mice may open the door for intracellular imaging mammalian animals, implying its potential tumor biology studies and theranostics.
DNA logic circuits (DLC) enable the accurate identification of specific cell types, such as cancer cells, but they face challenges weak output signals and a lack competent platforms that can efficiently deliver DLC components to target site in living body. To address these issues, we rationally introduced cascaded biological amplifier module based on Primer Exchange Reaction inspired by electronic circuit devices. As paradigm, three abnormally expressed Hela microRNAs (-30a, -17, -21) were...
Deoxyribozyme (DNAzyme) is regarded as a promising gene therapy drug. However, poor cellular uptake efficacy and low biological stability limit the utilization of DNAzyme in therapy. Here, we report well-known programmable DNAzyme-based nanotweezer (DZNT) that provides new strategy for detection TK1 mRNA survivin mRNA-targeted silencing At end DZNT arm, there are two functionalized single-stranded DNA each consists parts: segment complementary to split-DNAzyme segment. The hybridization with...
A novel H 2 O -responsive carbon monoxide nanogenerator was designed by encapsulating manganese carbonyl prodrug into porphyrinic covalent organic polymers for realizing the combined CO gas and photodynamic therapy under light irradiation.
Nowadays surfactants were used to wash oily sludge and reclaim oil. This paper presents the optimum conditions for washing with surfactant solutions using single factor experiment. The agents tested are AEO-9, Peregal O, TritonX-100, sodium metasilicate dodecylbenzene sulfonate (DBS). In experiments, four factors affecting residual oil rate investigated which include liquid/solid mass rate, reaction temperature, time eluent fraction. Results obtained through experimental runs compared select...
Investigating multiple miRNA expression patterns in living cells by DNA logic biocomputing is a valuable strategy for diagnosis and biomedical studies. The introduction of protein enzymes circuits not only expands the toolbox nucleic acid assembly techniques, but also further improves specificity recognizing processing input. Herein, polymerase-driven primer exchange reaction, acting as sensing module, introduced into system transduces miRNAs event intermediate triggers activating subsequent...
DNA nanomachines have received great interest due to their potential mimic various natural biomolecular machines. Intracellular pH sensing and imaging are of significance understand cellular behaviors disease diagnostics. In this work, we report the novel molecular switching a self-assembled 3D triangular prism nanomachine (TPN) for in living cells. The TPN was quantitative yields by hybridization with two triangles three I-strands (containing i-motif sequences). At acidic conditions,...
In this work, we report a photocontrolled and self-powered DNA walking machine with bipedal DNAzyme walkers for intracellular microRNA imaging.
Dysbiosis of gut microbiota and metabolic pathway disorders are closely related to the ulcerative colitis. Through network pharmacology, we found that puerarin is a potential ingredient can improve crypt deformation inflammatory infiltration in mice, decrease levels IL-1β, IL-6 TNF-α significantly. Listeria , Alistipes P. copri gradually became dominant bacteria UC which were positively correlated with factors. Puerarin effectively improved dysbiosis by reducing abundance Veillonella...
Simultaneous imaging and especially visualizing the association of survivin mRNA telomerase in living cells are great value for diagnosis prognosis cancer because their co-expression facilitates development identifies patients at high risk tumor-related death. The challenge is to develop methods that enable multiplex targets avoid distorted signals due different delivery efficiency probes. Herein, we engineered a DNA triangular prism nanomachine (DTPN) simultaneous multicolor cells. Two...
In this work, we have developed a novel DNAzyme motor initiated by endogenous enzyme for sensitive imaging of intracellular RNase H activity.
An intelligent DNA-MnO<sub>2</sub> nanodevice was designed for the telomerase-activated photodynamic (PDT) and gene-silencing synergistic effect cancer cells theranostic.
A novel and highly selective signal amplification strategy was developed based on target-assisted self-cleavage DNAzyme probes for imaging of miRNA-222 miRNA-223.
Ribonuclease H (RNase H), an intracellular ribonuclease, plays a crucial role in cellular processes and especially relates to many disease processes. Here, we report novel signal amplification strategy based on RNase H-powered DNA walking machine for specific sensitive activity detection. The is composed of small quantity walker strands abundant FAM-labeled DNA-RNA chimeric single gold nanoparticle (AuNP). can specifically degrade the RNA fragment hybrid duplex trigger autonomous movement...