A5101521709- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Tissue Engineering and Regenerative Medicine
- Reproductive Health and Contraception
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Diabetes Research and Management
- Reproductive Health and Technologies
- Mesenchymal stem cell research
- Pregnancy and preeclampsia studies
- Energy and Environment Impacts
- Pluripotent Stem Cells Research
- Folate and B Vitamins Research
- Spaceflight effects on biology
- Maternal and fetal healthcare
- Birth, Development, and Health
- Retinoids in leukemia and cellular processes
- Ovarian function and disorders
- Global Health Care Issues
- Ectopic Pregnancy Diagnosis and Management
- Genomics, phytochemicals, and oxidative stress
- Spinal Cord Injury Research
- Sperm and Testicular Function
- Software Testing and Debugging Techniques
- Teratomas and Epidermoid Cysts
- Neurogenesis and neuroplasticity mechanisms
Tianjin Municipal Research Institute for Family Planning
2016-2024
Chinese National Human Genome Center
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
Peking Union Medical College Hospital
2012-2024
Jining Medical University
2023
National Health and Family Planning Commission
2011-2022
Institute of Genetics and Developmental Biology
2022
Chinese Academy of Sciences
2022
Ningxia Normal University
2018
Abstract African swine fever virus (ASFV), the aetiological agent of (ASF), causes lethal haemorrhagic in domestic pigs with high mortality and morbidity has devastating consequences on global industry. On-site rapid sensitive detection ASFV is key to timely implementation control. In this study, we developed a rapid, instrument-free method based CRISPR/Cas12a technology lateral flow (named CRISPR/Cas12a-LFD). The limit CRISPR/Cas12a-LFD 20 copies genomic DNA per reaction, process can be...
Abstract Background Emerging evidence suggests that miR-124 performs important biological functions in neural stem cells (NSCs); it regulates NSC behavior and promotes the differentiation of NSCs into neurons, but exact molecular mechanism remains unknown. And also, role during spinal cord injury regeneration is unclear. Materials methods In order to explore function differentiation, markers (Tuj1, Map2, GFAP) correlated with were detected by immunofluorescence staining both cultured mouse...
Limited studies have examined the impact of airborne particulate matter 2.5 μm or less (PM2.5) on renal function. No study has effect PM1, which is small enough to reach blood circulation. We whether exposure PM1 PM2.5 affected function young Han Chinese. included 2,546,047 adults who were aged 18 45 years, being ethnicity and had no chronic disease from a Chinese national birth cohort. Serum creatinine (Scr) each participant was measured during baseline examination. Estimated glomerular...
Little is known about the effect of ambient temperature on preterm birth, especially for trimester-specific effects. To evaluate whether exposure to relatively low or high during pregnancy associated with increasing risk birth not. We analysed data a cohort 1,281,859 singleton pregnancies 2013–2014 and matched home address each pregnant women model based daily meteorological air pollution data. Then we used Cox proportional hazard regression models random estimate non-linear associations...
Numerous studies have indicated that microgravity induces various changes in the cellular functions of neural stem cells (NSCs), and use to culture tissue engineered seed for treatment nervous system diseases has drawn increasing attention. The goal this study was verify efficacy collagen sponge-based 3-dimensional (3D) NSCs cultured a rotary cell (RCCS) treating spinal cord injury (SCI). Basso-Beattie-Bresnahan score, inclined plane test, electrophysiology results all 3D RCCS had better...
What is the relationship between pre-pregnancy maternal glucose levels and fecundability in Chinese couples?Elevated were associated with fecundability, as reflected by prolonged time to pregnancy (TTP) among couples no prior gravidity.Based on National Free Pre-conception Check-up Projects supported government, 2 226 048 eligible attempting first participating project from 2015 2016 included. They followed-up for 1 year or until they reported pregnancy.The Kaplan-Meier method was used...
Abstract Background Although sexually transmitted infections are regarded as the main cause of tubal infertility, association between common vaginal microbiome and female fecundability has yet to be determined. The objective this study was find convincing evidence relating impact bacterial structure on women planning pregnancy. Methods We recruited who took part in Free Pre-pregnancy Health Examination Project from 13 June 2018 31 October ( n = 89, phase I) 1 November 30 May 2020 389, II)....
Neural tube defects (NTDs) are one of the most common types birth defects, affecting approximately 1 every 1000 pregnancies in United States and an estimated 300 000 newborns worldwide each year. The metabolic signature pregnant women with NTDs offspring has not previously been characterized. In this paper, we report a profiling study that characterized serum metabolome 101 affected comparison 143 normal pregnancy outcomes Lvliang prefecture, area highest prevalence China. A metabonomic was...
Abstract Endometrial injury can cause intrauterine adhesions (IUA) and induce the formation of endometrial fibrosis, leading to infertility miscarriage. At present, there is no effective treatment method for severe IUA uterine basal with adhesion area larger than one-third uterus. In this study, we prepared FGF1 silk sericin hydrogel material (FGF1-SS hydrogel) treat prevent fibrosis. Compared (WT-SS hydrogel), FGF1-SS significantly promotes cell migration infiltration ability stromal cells...
Background: Potential modification of the association between maternal particulate matter (PM) exposure and preterm delivery (PTD) by folic acid (FA) supplementation has not been studied. Objective: We examined whether FA could reduce risk PTD associated with to PM in ambient air during pregnancy. Method: In a cohort study covering 30 31 provinces mainland China 2014, 1,229,556 primiparas Han ethnicity were followed until labor. collected information on their pregnancy outcomes estimated...
Abstract Background Recently, neural stem cell (NSC) therapy has shown promise for the treatment of many neurological diseases. Enhancing quality implanted cells and improving therapeutic efficacy are currently research hotspots. It been reported that collagen sponge material provided sufficient room growth in all directions promoted absorption nutrients removal wastes. And also, Rotary Cell Culture System (RCCS), which mimics microgravity environment, can be used to culture tissue...
To investigate the relationship between ambient fine particulate matter (PM2.5) exposure and fecundability. This study included 751,270 female residents from Henan Province who participated in National Free Pre-conception Check-up Projects during 2015–2017. Ambient cycle-specific PM2.5 was assessed at county level for each participant using satellite-based concentration data 1-km resolution. Cox proportional hazards models with time-varying were used to estimate association fecundability...
Abstract STUDY QUESTION Do couple’s age ranges for optimal fecundability, and the associations with fecundability of combinations differences differ gravidity? SUMMARY ANSWER The range differed gravidity, gravidity might modify spousal difference fecundability. WHAT IS KNOWN ALREADY Age is one strongest determinants but existing studies have certain limitations in study population, extreme differences, not explored whether association between differs gravidity. DESIGN, SIZE, DURATION...
Aim: The major symptom of many closed spinal dysraphism patients is that the laminas or arches vertebra are not fused well. To date, bone repair spina bifida for young children a significant challenge in clinical practice. Materials & methods: Bovine collagen particle (BBCP) scaffolds combined with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were implanted defect area. X-ray analysis was performed after 3 months. Tissues harvested gross observation, and histological...
To evaluate the association between vaginal microenvironment and fecundability among women.Register-based nationwide cohort study.Chinese National Free Pre-conception Check-up Project from 2015 to 2018.Our study included a total of 3 388 554 eligible women who were attempting become pregnant.We assessed at baseline by considering four indices: pH, clue cell examination, whiff test cleanliness grading. If any these indicators was abnormal, defined as poor. Propensity score matching used...
Anaemia is a global public health problem affecting women worldwide, and reproductive-age are at increased risk. We conducted population-based cross-sectional study analysing the prevalence of overall anaemia according to severity in Chinese pre-pregnant update current knowledge on epidemiology. Based National Free Preconception Check-up Projects supported by government, 5 679 782 participating this project 2017 were included present study. The cyanmethemoglobin method was applied assess Hb...
<p dir="ltr">Objective: Evidence on the associations between fine particulate matter (PM2.5) and diabetes risk from women of reproductive age, whom may have adverse long-term health effects both themselves future generations, remains scarce. We therefore examined PM2.5 exposure with fasting blood glucose (FBG) levels among reproductive-aged in China.</p><p dir="ltr">Research Design Methods: This study included 20,076,032 aged 20-49 years participating National Free...
Importance Many studies have reported that the interpregnancy interval (IPI) is a potential modifiable risk factor for adverse perinatal outcomes. However, association between IPI after live birth and subsequent spontaneous abortion (SA) unclear. Objective To investigate of healthy SA. Design, Setting, Participants This prospective cohort study used data from 180 921 women aged 20 to 49 years who had single planned another pregnancy participated in Chinese National Free Prepregnancy Checkups...