Introduction: Primary Ovarian Insufficiency (POI) due to single gene variant is classified as a 46,XX difference of sexual development. Variants in the Helicase Family Member 1 (HFM1) are associated with POI females and non-obstructive azoospermia males. Case report：We described case unique genital characteristics, including clitoromegaly, fusion labia majora, an opening urethral meatus at perineum, absence vaginal opening. Hormonal analysis revealed hypergonadotropic hypogonadism. Genetic...

Tumor-targeted immunotherapy is a remarkable breakthrough, offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity. However, existing platforms suffer from low efficacy, inability to induce strong immunogenic cell death (ICD), and restrained capacity transforming immune-deserted tumors into immune-cultivated ones. Here, an innovative platform, perfluorooctyl bromide (PFOB) nanoemulsions holding MnO2 nanoparticles (MBP), was developed...

A novel drug delivery vehicle using nanodroplets activated by light irradiation for release in a controlled manner has been developed. The encapsulated the was released upon phase transition from liquid droplet to microbubbles (vaporization) plasmonic photothermal heat gold nanorods adsorbed on surface of nanodroplets. were stable against aggregation and dissolution at 4 °C over 3 months date. quantitatively analyzed ultrasound imaging examine amount noninvasively. In vitro studies showed...

To treat chronic posterior eye diseases, frequent intravitreal injections or sustained-release drug implants are the current standard of care. Sustained-release often involve burst release drugs and dosage from cannot be controlled after implantation, which may lead to local side effects. The present study attempts develop a dosage-controllable delivery implant that consists nanoporous biodegradable PLGA capsule light-activated liposomes. Controllable was achieved using pulsed near-infrared...

Although several studies have demonstrated repetitive drug release using light-activatable liposomes, inconsistent at each activation limits widespread usage. Here, we report reversible plasmonic material-coated encapsulated liposomes for proportional controlled delivery of methotrexate (MTX), which is a common cancer and autoimmune diseases, laser irradiation. Our results suggest increase in total after We hypothesize that the released via "melted" lipid bilayers when materials on liposome...

The present paper is part two of a small series three publications on spontaneous breakages toughened glass. In one, we deal with the detailed effects crystallographic and physical properties nickel sulphide species contained in those inclusions; find that solely under this aspect, only c. 40% Heat Soak Test (HST) according to, e.g., EN 14179-1:2006, would be physically able to cause breakage façade. partly builds up these findings. paper, prove experimentally inclusions are found everywhere...

The current standard of care for posterior segment eye diseases, such as neovascular age-related macular degeneration, diabetic edema, is frequent intravitreal injections or sustained-release drug implants. Intravitreal have a low incidence serious complications retinal detachment, endophthalmitis, iatrogenic traumatic cataract, iridocyclitis and injection-site reactions. However, there significant burden to the patient, patient's family, health system because therapies require between every...

Purpose: To compare the objective visual quality of moderate-to-high myopia corrected by small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (TransPRK) at a 1,050-Hz ablation frequency, assisted Smart-Pulse technology (SCHWIND eye-tech-solutions). Methods: This study involved 123 patients (123 eyes) with between July 2020 January 2021. They were categorized into SMILE group (67 patients, 67 TransPRK (56 56 eyes). Follow-ups conducted 6 months...

In current engineering, the transition process of pump turbines from to turbine mode mainly includes shutdown operating and startup operating, switching working conditions mostly depends on opening closing ball valve. While, this article focuses transitional condition without relying valve, which will significantly reduce response time unit enable quick in emergency situations. study, torque balance equation is employed analyze entire flow system operation. Additionally, entropy production...

Objective: There is a notable absence of extensive Chinese studies involving monogenic congenital hyperinsulinism (CHI). The purpose this large retrospective cohort with CHI from national children’s medical center was to analyze the genetic and clinical characteristics. Methods: We compared characteristics grouped by genotypes based on CHI‐targeted next‐generation sequencing (tNGS) performed subgroup analyses onset time. Results: Totally, 121 non‐consanguineous patients were enrolled. Among...

Abstract This paper is concerned with Nakajima test and forming limit curve (FLC) of stainless 304 ultra-thin sheet metal in relation to the strain rate effect. The mechanical properties related micro structure specimens are studied based on quasi static tension test. curves constructed by tests two different rates, quasi-static high speed rate. Compared FLC, FLC for all thickness lower through entire region. results confirm that rates have a noticeably influence formability metal....

In order to further reduce the weight and at same time guarantee automobile safety, hot stamping of Tailor-Welded Blanks (TWBs), is developed recently meet environmental safety requirements by supplying car structural body components with functionally optimized tailored mechanical properties. article, an appropriate partner material for quenchenable boron steel B1500HS based on phase transformation deformation behavior under process relevant conditions determined. Microhardness measured...

The grinding hardening workpiece deformation caused by high temperature leads to the variation of force. Grinding force dynamic affects depth hardened layer distribution. So it is necessary study rule Through arc analysis and analysis, influence factor for on analyzed. results are compared with experimental results.

A three-dimensional(3D) model of the shoe toe is established by CACX and UG software in this paper. Then process analysis calculations product are done with DYNAFORM software. The most reasonable technology scheme related die construction determined end.

Objective To evaluate the action for optic nerve protection of engeron extracts in treating glaucoma with control intraocular pressure. Methods Thiny-four patients (42 eyes) who met inclusion criteria, randomized, double-blind and placebo-controlled clinical trial were divided into treatment group given oral Yi Mai Kang capsules placebo, observed every two months to test security (blood pressure, liver function, renal function) outcome measures (visual acuity, visual field, HRT), evaluated...

Grind-hardening is a new technology for steel parts surface enhancing which uses thermal and mechanical composite effects on the in grinding process. During process, workpiece generates hardened layer improves quality. As key performance indicator of measuring part quality, residual stress affects strength, fatigue life corrosion directly. Therefore, study plays an important role effective control First, temperature field analysed studying distribution characteristics after grind-hardening...

Abstract The current standard of care for posterior segment eye diseases, such as age-related macular degeneration and diabetic edema, is frequent intravitreal injections or sustained-release drug implants. Drug implants have side effects due to the burst release drugs, their cannot be easily controlled after implantation. Present study attempts develop a dosage-controllable delivery implant which consists nanoporous biodegradable PLGA capsule light-activated liposomes. Controllable from was...