A5016160553- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Impairment Studies
- Traumatic Ocular and Foreign Body Injuries
- Retinal Development and Disorders
- Retinopathy of Prematurity Studies
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Advanced Glycation End Products research
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Facial Trauma and Fracture Management
- Visual perception and processing mechanisms
- Corneal surgery and disorders
- Neonatal Respiratory Health Research
- Cerebral Venous Sinus Thrombosis
- Genetic Associations and Epidemiology
- Systemic Lupus Erythematosus Research
- Ocular Surface and Contact Lens
Australian National University
2015-2025
Canberra Hospital
2015-2024
The Royal Victorian Eye & Ear Hospital
2003-2022
Monash University
2022
ACT Government
2012-2022
Government of the Northern Territory
2021
Institute of Ophthalmology
2018
Tilganga Institute of Ophthalmology
2018
Westmead Hospital
2015
Technology Centre Prague
2015
To describe the development of a web-based high-quality data collection tool to track outcomes treatment macular disease in routine practice.Testing larger established which fields clinician would reliably fill out. The program, was developed using freely available software, consists modules interacting with core system. module for neovascular age-related degeneration is described here.Data initial visits can be entered within 30 seconds, 15 seconds follow-up visits. Fifteen centers from...
To report 24-month outcomes of a treat and extend (T&E) regimen using aflibercept in eyes with neovascular age-related macular degeneration.This was database observational study that included treatment-naive degeneration tracked by the Fight Retinal Blindness! outcome registry completing 24 months sole monotherapy treatment under T&E between November 1, 2012 January 31, 2014. Locally weighted scatterplot smoothing curves were used to display visual acuity outcomes. Main measures change at...
Bevacizumab (Avastin) is a monoclonal antibody which targets all isoforms of vascular endothelial growth factor A. Its potent anti-angiogenic effects have been shown to cause regression neovascularization in proliferative diabetic retinopathy. The aim this study investigate the role Avastin as an adjunct vitrectomy management severe eye disease.Sixteen patients (18 eyes) with retinopathy were recruited into study. All eyes underwent single intravitreal injection bevacizumab 1.25 mg 0.05 mL...
To describe the clinical features and outcomes of a large group patients with spectrum appearances diagnosed as having punctate inner choroidopathy (PIC).In retrospective consecutive case series, seen during 16-year period at Moorfields Eye Hospital who were PIC had minimum 12 months' follow-up included. Patients classified typical or atypical (larger, presumed ocular histoplasmosis syndrome-like lesions). Main outcome measures included development choroidal neovascularization, new lesions,...
Vitreoretinal lymphoma is a diffuse large B cell non-Hodgkin lymphoma. Targeting malignant cells with rituximab being used increasingly as local chemotherapy, but information on this treatment scant. We aimed to describe current therapeutic approaches, well responses and complications of, intravitreal in patients vitreoretinal lymphoma.Clinical data were collected standardised manner retrospectively treated rituximab.48 eyes (34 patients) median of 3.5 injections (1 mg/0.1 mL) for new...
Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are sight-threatening complications of diabetes mellitus leading causes adult-onset blindness worldwide. Genetic risk factors for (DR) have been described previously, but difficult to replicate between studies, which often used composite phenotypes conducted in different populations. This study aims identify genetic DME PDR as separate Australians European descent with type 2 diabetes. Caucasian were evaluated a...
Careful surgical management of traumatic wounds is important in open globe injury repair. This study examines the clinical outcomes following repair injuries with particular focus on wound-related issues.Retrospective, cohort consecutive presenting to a tertiary referral eye hospital from 1 January 2009 31 December 2011.A total 267 eyes 263 patients, mainly male (82.5%) mean age 44.8 (range: 4-97) years. Average follow up was 6.9 months.All cases classified according Ocular Trauma...
We sought to determine the role and retinal cellular location of microRNA-124 (miR-124) in a neuroinflammatory model degeneration. Further, we explored anti-inflammatory relationship miR-124 with predicted messenger RNA (mRNA) binding partner, chemokine (C-C motif) ligand 2 (Ccl2), which is crucially involved inflammatory cell recruitment damaged retina.Human AMD donor eyes photo-oxidative (PD) mice were labeled for expression using situ hybridization. PDGFRa-cre RFP used Müller isolation...
Aims Previous studies and community information about everyday difficulties in age-related macular degeneration (AMD) have focussed on domains such as reading driving. Here, we provide the first in-depth examination of how impaired face perception impacts social interactions quality life AMD. We also develop a Faces Social Life AMD brochure sheet, plus accompanying conversation starter, aimed at patients those who interact with them (family, friends, nursing home staff). Method...
Abstract Multifocal pupillographic objective perimetry (mfPOP) shows regions of slight hypersensitivity away from retinal damaged by diabetes or age-related macular degeneration (AMD). This study examines if such results also appear in multifocal visual evoked potentials (mfVEPs) recorded on the same day patients. The pupil control system receives input extra-striate cortex, so we examined evidence for input. We recruited subjects with early type 2 (T2D) no retinopathy, and patients...
<h3>Aims</h3> To examine 12-month outcomes of eyes switching from intravitreal ranibizumab to aflibercept for neovascular age-related macular degeneration (nAMD). <h3>Methods</h3> Database observational study with nAMD tracked by the Fight Retinal Blindness outcome registry that received at least 12 months before and followed after switch. Visual acuity (VA) recorded switch was analysed using locally weighted scatterplot smoothing curves. Lesion activity graded according a prospectively...