A5060316399- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- Glaucoma and retinal disorders
- Cerebral Venous Sinus Thrombosis
- Immunodeficiency and Autoimmune Disorders
- Osteomyelitis and Bone Disorders Research
- Neuropeptides and Animal Physiology
- Ocular Infections and Treatments
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Acute Ischemic Stroke Management
- Inflammasome and immune disorders
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Herpesvirus Infections and Treatments
- Cancer Immunotherapy and Biomarkers
- Otitis Media and Relapsing Polychondritis
- PARP inhibition in cancer therapy
Queen's University
2018-2025
Concord Repatriation General Hospital
2005-2024
Vision Australia
2024
ACT Government
2024
Centre Hospitalier de Saint-Brieuc
2024
CHU Dijon Bourgogne
2024
Canberra Hospital
2024
Centre for Eye Research Australia
2024
Motor Neurone Disease Research Australia
2016-2022
Bergman Clinics
2022
ABSTRACT Purpose : To report the safety and efficacy of intravitreal triamcinolone in treatment inflammatory cystoid macular oedema (CMO) six patients who were resistant to other forms therapy. Methods An open‐label unmasked prospective non‐ randomized pilot study with idiopathic uveitis visually significant oedema, periocular and/or systemic corticosteroid treatment, was carried out. Baseline examination investigations performed, including fundus fluorescein angiography, given a single...
Chemically stabilized small interfering RNA (siRNA) can be delivered systemically by intravenous injection of lipid nanoparticles (LNPs) in rodents and primates. The biodistribution kinetics LNP-siRNA delivery mice at organ cellular resolution have been studied using immunofluorescence (IF) staining quantitative polymerase chain reaction (qPCR). At 0.5 2 hr post tail vein Cy5-labeled siRNA encapsulated LNP, the rank-order levels is liver > spleen kidney, with only negligible accumulation...
Abstract Background Failure of immunotherapy in high-grade serous ovarian cancer (HGSC) may be due to high levels transforming growth factor-β (TGF-β) ascites or tumour immune microenvironment (TIME). Here, we test whether coordinated blockade TGF-β and PD-L1 with bintrafusp alfa (BA) can provoke anti-tumour responses preclinical HGSC models. Methods BA is a first-in-class bifunctional inhibitor PD-L1, was tested for effects on overall survival altered TIME syngeneic Results Using mouse...
Abstract Introduction: High grade serous cancer (HGSC) is the most common and lethal subtype of epithelial ovarian cancer, with only ∼25% survival rates at 5 years post diagnosis. Transforming Growth Factor-beta (TGF-β) an immunosuppressive cytokine found in high levels ascites fluid that hinders efficacy PD-(L)1 immune checkpoint blockade. Specifically, TGF-β signaling promotes recruitment activation cells, including regulatory T cells (Tregs) tumor-associated macrophages (TAMs). Here, we...
Objective To assess the role of intravitreal administration high doses ganciclovir as a supplement and alternative to intravenous in treatment cytomegalovirus (CMV) retinitis patients with acquired immunodeficiency syndrome (AIDS). Design A retrospective study visual outcome, relapse complications dose alone combination. Method Twenty-three AIDS CMV (37 eyes) were examined by authors notes, fundal drawings photographs reviewed. Initially treated given supplementary therapy for or...
<h3>Aims</h3> To describe subretinal debris found on ultrastructural examination in an eye with macular telangiectasia (MacTel) type 2 and optical coherence tomography (OCT) a subset of patients MacTel 2. <h3>Methods</h3> Blocks from the mid-periphery temporal perifovea clinically documented were examined electron microscopy (EM). Cases came Sydney centre project practices authors. <h3>Results</h3> On EM examination, was accumulation degenerate photoreceptor elements space. Despite...
To compare 1-year outcomes of eyes with diabetic macular edema (DME) treated in routine clinical practice based on the proportion visits where intravitreal VEGF inhibitor injections were delivered.
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Although intravitreal high dose ganciclovir has previously been found to provide excellent control of cytomegalovirus (CMV) retinitis, little was known about the vitreous concentrations after a 2 mg injection.Eleven samples were taken from seven patients with CMV retinitis at 24 and 72 hours injection concentration measured by performance liquid chromatography.The mean 143.8 mg/l (95% confidence interval 97.8-190) 23.4 CI 0-49.7). The half life ranged 11.9 26.3 (mean 18.8) in four who had...
Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy can lead to addiction. In humans, functional loss of voltage-gated sodium channel Na v 1.7 leads pain insensitivity without deficits central nervous system. Accordingly, discovery selective antagonist should provide an analgesic abuse liability improved side-effect profile. Huwentoxin-IV, component tarantula venom, potently blocks...
Abstract Amplification of HER2 leads to development HER2-positive (HER2+) cancers with high rates metastasis compared other cancer subtypes. The goal this study was probe the vulnerability HER2+ cells a filamentous actin (F-actin) severing and capping toxin. growth viability human breast (HCC1954) ovarian (SKOV3) cell lines were significantly impaired upon treatment marine macrolide mycalolide B (Myc B) at doses above 100 nanomolar. Further testing Myc in combination antibody-drug conjugate...
ABSTRACT Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease, and patients with active or recurrent inflammation at multiple sites are diagnosed chronic multifocal (CRMO). The (CMO) mouse model develops IL-1β-driven sterile lesions reminiscent of severe CRMO. goal this study was to evaluate the potential involvement mast cells in CMO/CRMO. Here, we show that accumulate inflamed tissues from CMO mice cell protease Mcpt1 can be detected peripheral blood. A transgenic...