A5055234252- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Ocular Infections and Treatments
- Retinopathy of Prematurity Studies
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Vascular Malformations Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Dermatological and Skeletal Disorders
- Medical History and Innovations
- Ocular Surface and Contact Lens
- Dental Anxiety and Anesthesia Techniques
- Glioma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Ischemic Stroke Management
- CNS Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Vascular Tumors and Angiosarcomas
Hospital General de Granollers
2018-2025
Vision Australia
2024
ACT Government
2024
Centre Hospitalier de Saint-Brieuc
2024
CHU Dijon Bourgogne
2024
Canberra Hospital
2024
Centre for Eye Research Australia
2024
Hospital General de Catalunya
2016-2022
Universitat Autònoma de Barcelona
1997-2007
Instituto de Microcirugía Ocular
2007
To assess the safety and efficacy of different doses RTH258 applied as single intravitreal administration compared with ranibizumab 0.5 mg in patients neovascular age-related macular degeneration (AMD).Six-month, phase 1/2, prospective, multicenter, double-masked, randomized, ascending single-dose, active-controlled, parallel-group study.A total 194 treatment-naive patients, aged ≥50 years, primary subfoveal choroidal neovascularization secondary to AMD.Patients received a injection (n =...
To evaluate the efficacy, effect profile, and safety of dexamethasone implant on diabetic macular edema (DME) in a real-life setting, further comparing results by DME duration, previous treatment status, control.A multicenter, retrospective cohort 340 eyes 287 patients from 25 clinical sites 8 countries.Data were analyzed 2 perspectives: per injection, which all measurements grouped baseline was defined as day thus pharmacodynamics single injections could be assessed; injection series, or...
Aim To explore associations between artificial intelligence (AI)-based fluid compartment quantifications and 12 months visual outcomes in OCT images from a real-world, multicentre, national cohort of naïve neovascular age-related macular degeneration (nAMD) treated eyes. Methods Demographics, acuity (VA), drug number injections data were collected using validated web-based tool. Fluid including intraretinal (IRF), subretinal (SRF) pigment epithelial detachment (PED) the fovea (1 mm),...
Geographic atrophy (GA) secondary to age-related macular degeneration is a common cause of blindness worldwide. Given the recent approval first therapy for GA, pegcetacoplan, we critically appraise methodological aspects phase 3 clinical trials published so far in this disease relation their design, analysis and interpretation. We reviewed some key attributes all GA available main public registry as 20 May 2023. The topics discussed included types endpoints, eligibility criteria, p-value...
Aim To evaluate the impact of fluid volume fluctuations quantified with artificial intelligence in optical coherence tomography scans during maintenance phase and visual outcomes at 12 24 months a real-world, multicentre, national cohort treatment-naïve neovascular age-related macular degeneration (nAMD) eyes. Methods Demographics, acuity (VA) number injections were collected using Fight Retinal Blindness tool. Intraretinal (IRF), subretinal (SRF), pigment epithelial detachment (PED), total...
Purpose: To determine if vitreoretinal surgery is successful in closing traumatic macular holes and subsequently improving visual acuity. Blunt trauma may result a hole when it causes separation of the vitreous from retina, contusion necrosis, or subfoveal hemorrhage. Like idiopathic holes, are surrounded by ring subretinal fluid severely diminished Methods: Fourteen eyes with full-thickness posttraumatic were treated. The patients' ages ranged 15 years to 36 (mean, 22 years). Preoperative...
Purpose: To compare the visual disturbances experienced by patients receiving 1 of 3 extended depth-of-focus (EDOF) intraocular lenses (IOLs) or a monofocal IOL as control. Setting: OMIQ-Recerca Center. Spain. Design: Prospective comparative randomized double-blind study. Methods: 22 were included per group. The IOLs evaluated AcrySof IQ Vivity (Vivity group), AT LARA 829MO (AT Lara TECNIS Symfony ZXR00 (Symfony group) and SN60WF (Monofocal group). variables analyzed light distortion index...
OBJECTIVE—To evaluate the vitreous levels of somatostatin-like immunoreactivity (SLI) in patients with proliferative diabetic retinopathy (PDR). RESEARCH DESIGN AND METHODS—A total 14 PDR, whom a vitrectomy was performed, were included study. Sixteen nondiabetic patients, other conditions requiring vitrectomy, served as control group. Both venous blood and samples collected at time vitreoretinal surgery. Patients intravitreous hemoglobin detectable excluded. In addition, correction for...
Eyes with posterior choroidal melanomas more than 9 mm in thickness frequently are enucleated because of the potential complications radiotherapy. The aim this study was to evaluate safety and efficacy internal resection these tumors.Twenty-five consecutive patients high a diameter less 15 greater were treated. If retina not invaded by tumor, vitrectomy performed, followed hyaloid dissection, 120 degrees anterior retinotomy, endophotocoagulation 2 past tumor margin, melanoma removal probe,...
To assess the relationship between risk for acute endophthalmitis after cataract extraction and whether certain factors, such as surgeon qualification, numerical order, duration of surgery, operating theater, type anesthesia (topical or retrobulbar), could be modified to decrease risk.Single-center academic practice.Two epidemiological studies were performed: a case-control study retrospective cohort study. The surgical records all patients with clinically diagnosed within 30 days surgery...
To study the visual outcomes of neovascular AMD (nAMD) treated with anti-vascular endothelial growth factor (VEGF) drugs at national level.Multicenter database nAMD eyes anti-VEGF intravitreal injections (ranibizumab, aflibercept, bevacizumab) in fixed bimonthly (FB) or treat-and-extend (TAE) regimens. Demographics, acuity (VA) logarithm minimum angle resolution (logMAR) ETDRS letters baseline and subsequent visits, number visits data were collected using a validated web-based tool (Fight...
Brolucizumab, a new generation anti-VEGF, has demonstrated efficacy and safety in AMD the pivotal HAWK HARRIER trials. Post-marketing, previously undetected adverse events related to intraocular inflammation have been reported. An independent post hoc review of trials puts rate IOI at 4.6%. The aim this paper is propose set recommendations for implementing management brolucizumab clinical practice. made by authors are based on their experience, critical (i) trials, post-hoc analysis Safety...
The purpose was to compare two flexible regimens of intravitreal aflibercept (IVT-AFL) with fixed dosing every 8 weeks, beyond the first year treatment, in patients diabetic macular edema (DME). VIOLET a 100-week, randomized, Phase IIIb, non-inferiority study center-involving DME previously treated IVT-AFL for ≥ 1 according European label.Patients received an initial dose at baseline and were randomly assigned (1:1:1) treat-and-extend (T&E), pro re nata (PRN), or regimens. primary endpoint...
To compare 1-year outcomes of eyes with diabetic macular edema (DME) treated in routine clinical practice based on the proportion visits where intravitreal VEGF inhibitor injections were delivered.
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Abstract Aims Several reports have implicated nitric oxide (NO) in the angiogenic process. The assessment of NO stable end products, nitrite and nitrate (NOx), is commonly used as a measure production biological fluids. aims study were to investigate NOx concentrations vitreous fluid patients with proliferative diabetic retinopathy (PDR) evaluate relationship between vascular endothelial growth factor (VEGF). Patients methods Serum samples obtained simultaneously at time vitreoretinal...
This study aimed to characterize the visual performance in patients with bilateral cataracts and a unilateral epiretinal membrane (ERM) undergoing cataract surgery non-diffractive extended depth of focus (EDoF) intraocular lens (IOL) placement both eyes phacovitrectomy eye ERM.
The aim of the study was to evaluate vitreous levels free insulin-like growth factor 1 (IGF-1) in patients with proliferative diabetic retinopathy (PDR). For this, a total 36 PDR (group A) and 28 non-diabetic B) whom vitrectomy performed were compared. Both groups matched by age, sex serum-free IGF-1. In subgroup (n = 21) 13), serum IGF-1, IGF-binding protein (IGFBP-1) IGFBP-3 also determined. Serum IGFBP-1 measured immunological methods. Vitreal proteins assessed turbidimetric method...