Abstract. Purpose: To evaluate the changes of vascular endothelial growth factor (VEGF) plasma levels after intravitreal injections ranibizumab or bevacizumab in patients with exudative age‐related macular degeneration (AMD). Methods: Forty‐three AMD and 19 age‐ sex‐matched control without chorioretinal diseases were studied. Nineteen treated 0.5 mg, 24 1.25 mg. Blood samples collected just before first injection, 28 days three initial consecutive performed 4‐weekly intervals (loading dose)....

Methods: In 14 eyes from patients, retinal macular thickness, choroidal submacular and peripapillary thickness were measured preoperatively at one week month after phacoemulsification using enhanced depth imaging spectral domain optical coherence tomography. Changes in of the different ocular tissues evaluated. Results: There was a statistically significant increase mean month. horizontal scans, +8.67±6.75 µm ( P <0.001), vertical +8.80±7.07 =0.001). However, there no changes morphology...

To evaluate choroidal morphology and thickness at the posterior pole of individuals affected by multisystemic autoimmune diseases without known ophthalmologic manifestations.Retrospective cross-sectional study including 75 patients with (divided according to their specific disease) 80 healthy controls. A spectral-domain optical coherence tomography using enhanced depth imaging was performed measured in center fovea 500 μm intervals along a horizontal section.Lupus presented thicker subfoveal...

&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; To report the clinical outcomes of intravitreal aflibercept therapy in eyes with refractory and recurrent neovascular age-related macular degeneration (AMD) switched from bevacizumab or ranibizumab. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; This is a retrospective review AMD to at least 1 year follow-up after switch. All patients had minimum 3 injections ranibizumab before Aflibercept was used considered (group 1) on due an institutional...

Background: Retinal diseases are emerging as a significant health concern, making early detection and prompt treatment crucial to prevent visual impairment. Optical coherence tomography (OCT) is the preferred imaging modality for non-invasive diagnosis. Both diabetic macular edema (DME) secondary retinal vein occlusion (RVO) present an increase in thickness, posing etiologic diagnostic challenges non-specialists diseases. The lack of research on deep learning classification RVO using OCT...

1.1. Background Body Mass Index (BMI) is a statistical tool used to estimate body fat based on person’s weight and height. This index applies men women of all ages, categorizing them as underweight, normal weight, overweight, or obese. These classifications are widely adopted by the World Health Organization (WHO) for white, Hispanic, black populations. Abdominoplasty surgical procedure designed remove excess skin from abdominal region strengthen wall muscles. BMI plays key role in this...

&lt;i&gt;Background/Aims:&lt;/i&gt; To compare retrospectively the incidence of arterial thromboembolic events (ATEs) in patients treated with bevacizumab or ranibizumab for exudative age-related macular degeneration. &lt;i&gt;Methods:&lt;/i&gt; Charts 378 at least 1 intravitreal injection were reviewed to calculate ATEs. Only under monotherapy analyzed. &lt;i&gt;Results:&lt;/i&gt; ATEs occurred 15 patients: 12 (12/97) (12.4%) and 3 (3/219) (1.4%) – odds ratio 10.16; 95% confidence interval...

Progression of diabetic macular edema has been reported as a common cause poor visual acuity recovery after cataract surgery in patients with diabetes. Despite being responsible for the blood supply to outer retina, role choroidal layer pathogenesis retinopathy (DR) is not yet understood. Our objective characterize and subfoveal thickness changes eyes DR.Thirty-five clinically significant DR were divided into three groups based on clinical optical coherence tomography findings: without...

The purpose of this study was to characterize the clinical presentation, management strategy and visual outcomes patients diagnosed with Terson syndrome followed in a tertiary centre Portugal.A single-centre retrospective performed, based on survey review medical records every consecutive patient from January 2018 August 2021. change best-corrected acuity (BCVA) baseline final evaluation primary outcome.Fifteen eyes 8 (50% female) were included. mean age at diagnosis 55±7 years. neurological...

Abstract Given its broad effects in endothelium, vascular endothelial growth factor (VEGF) represents the primary rate‐limiting step of angiogenesis. Therefore, VEGF targeting therapies were soon developed. Bevacizumab and ranibizumab are two these therapeutic agents already clinical use. was first used for cancer treatment, whereas designed to target choroidal neovascularization, main cause blindness age‐related macular degeneration. The present study aims compare multiple bevacizumab human...

&lt;i&gt;Aim:&lt;/i&gt; Evaluation of safety and efficacy intravitreal ranibizumab in the treatment choroidal neovascularization (CNV) secondary to causes other than age-related macular degeneration (AMD) or pathological myopia (PM). &lt;i&gt;Methods:&lt;/i&gt; Retrospective multicentric analysis 21 eyes with CNV. Nine had angioid streaks, 5 inflammatory chorioretinal diseases, 3 central serous chorioretinopathy 4 idiopathic Follow-ups lasted ≧3 months. Best-corrected visual acuity (BCVA),...

To characterize the neovascular lesions of patients with age-related macular degeneration (AMD) and outer retinal tubulations (ORTs).A retrospective study 377 eyes exudative AMD, submitted to intravitreal anti-angiogenic treatment. Patients were divided into 2 groups according presence or absence ORTs on spectral-domain optical coherence tomography (SD-OCT; group 1 - ORTs; without ORTs). Age, best corrected visual acuity (BCVA), fluorescein angiography characteristics, subretinal fibrosis...

Purpose . To evaluate the predictive factors of long-term visual outcomes in neovascular age-related macular degeneration (nAMD) treated with antivascular endothelial growth factor (anti-VEGF) agents. Methods Unicentric retrospective review patients nAMD anti-VEGF Visual outcomes, 12 and 60 months after diagnosis, were evaluated. In an attempt to identify multiple variables (demographic epidemiological characteristics, angiographic tomographic features) analyzed, at baseline during...

Purpose: The purpose was to compare the incidence of endophthalmitis after intravitreal injection with and without topical antibiotic prophylaxis. Methods: This is a single-center, retrospective case–control study. All patients treated ranibizumab, bevacizumab, aflibercept, or corticosteroids for variety retinal vascular diseases between 1 October 2014 30 November 2018 were included. total number injections determined from review billing code practice management records. Endophthalmitis...