A5029554179- Angiogenesis and VEGF in Cancer
- Mathematical Biology Tumor Growth
- Kruppel-like factors research
- Elasticity and Material Modeling
- Antibiotic Resistance in Bacteria
- Fungal Infections and Studies
- Electrospun Nanofibers in Biomedical Applications
- Numerical methods in engineering
- Tendon Structure and Treatment
- Salmonella and Campylobacter epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Numerical Methods in Computational Mathematics
- Nursing Roles and Practices
- Grouting, Rheology, and Soil Mechanics
- Microbial infections and disease research
- Infectious Diseases and Mycology
- Bone Tissue Engineering Materials
- Retinal Imaging and Analysis
- Interprofessional Education and Collaboration
- Escherichia coli research studies
- Cellular Mechanics and Interactions
- Lattice Boltzmann Simulation Studies
- Bacterial Identification and Susceptibility Testing
- Proteoglycans and glycosaminoglycans research
- Nail Diseases and Treatments
Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial
2023-2025
Institute of Mechanical Engineering and Industrial Mangement
2018-2025
Universidade do Porto
2018-2022
University of Lisbon
2011-2021
Hospital Garcia de Orta
2015-2021
Background: Retinal diseases are emerging as a significant health concern, making early detection and prompt treatment crucial to prevent visual impairment. Optical coherence tomography (OCT) is the preferred imaging modality for non-invasive diagnosis. Both diabetic macular edema (DME) secondary retinal vein occlusion (RVO) present an increase in thickness, posing etiologic diagnostic challenges non-specialists diseases. The lack of research on deep learning classification RVO using OCT...
The aim of this study was to report the antimicrobial resistance, molecular mechanisms associated and detection virulence determinants within faecal Enterococcus spp. Escherichia coli isolates Iberian wolf. Enterococci (n = 227) E. 195) were obtained from samples wolf (Canis lupus signatus). High rates resistance detected for tetracycline erythromycin among enterococci isolates, most resistant harboured tet(M) and/or tet(L) erm(B) genes, respectively. blaTEM, tet(A) tet(B), aadA or strA-strB...
The intensive use of antibiotics in human and veterinary medicine, associated with mechanisms bacterial genetic transfer, caused a selective pressure that contributed to the dissemination antimicrobial resistance different bacteria groups throughout ecosystems. Iberian wolf, due his predatory wild nature, may serve as an important indicator environmental contamination resistant bacteria. aim this study was characterize diversity extended-spectrum β-lactamase (ESBL)-producing Escherichia coli...
This study employs a meshless computational model to investigate the impacts of compression and traction on angiogenesis, exploring their effects vascular endothelial growth factor (VEGF) diffusion subsequent capillary network formation. Three distinct initial domain geometries were defined simulate variations in cell sprouting VEGF release. Compression applied, ensuing coefficients analysed. promoted increasing density. The reduction coefficient under altered concentration, impacting...
Background. Nocardiosis is a rare disease that mainly affects severely immunocompromised patients. Symptoms are nonspecific and microbiological isolation difficult, hiding the diagnosis. Treatment should be guided by species susceptibility testing. Findings. We report clinical case of disseminated nocardiosis in patient with HIV HVB infections. Interpretation. Diagnosis presumed early conditions optimized, order to identify achieve antibiotic This very important step choose an effective...
One of the complex challenges faced presently by tissue engineering (TE) is development vascularized constructs that accurately mimic extracellular matrix (ECM) native in which they are inserted to promote vessel growth and, consequently, wound healing and regeneration. TE technique characterized several stages, starting from choice cell culture more appropriate scaffold material can adequately support supply them with necessary biological cues for microvessel development. The next step...
Abstract Angiogenesis, the development of new blood capillaries, is crucial for wound healing process. This biological process allows proper supply to tissue, essential cell proliferation and viability. Several factors modulate angiogenesis, however vascular endothelial growth factor (VEGF) main one. Given complexity in last years, computational modelling aroused interest scientists since it model this with different, more economic faster methodologies, comparatively experimental approaches....
Cryptococcal meningitis is a common opportunistic infection in HIV-infected patients and other immunocompromised people. Pregnancy, which state of relative immunosuppression, can also be risk factor for the development cryptococcal meningitis. We report clinical case 41-year-old woman who developed severe meningeal syndrome after an otherwise normal pregnancy. Cerebrospinal fluid (CSF) cytochemical analysis presented hypoglycorrhachia, high protein levels, pleocytosis. antigen tested...
This study aims to investigate the impact of compressive loading on endothelial cell migration pattern in angiogenesis using a meshless discretization technique, combined with reaction-diffusion formulation. In silico models are highly valuable for understanding dynamics biological systems, and numerical allow testing different laboratory protocols deducing which ones produce best outcomes. proposed model, was simulated response equation vascular growth factor (VEGF) 5×5 mm <sup...
Background: Understanding vascular development and the key factors involved in regulating angiogenesis—the growth of new blood vessels from pre-existing vasculature—is crucial for developing therapeutic approaches to promote wound healing. Computational techniques offer valuable insights into improving angiogenic strategies, leading enhanced tissue regeneration improved outcomes chronic While chorioallantoic membrane (CAM) models are widely used examining fundamental mechanisms development,...
The epiretinal membrane is a thin sheet of fibrous tissue that can form over the macular area retina, and may result in loss visual acuity or metamorphopsia, due to superficial retinal folds. A vitrectomy surgery, current treatment procedure for this pathology, only performed after symptoms are present. However, sometimes patients do not present any vision improvements surgery. use computational methods patient-specific biomechanical analysis contribute better understanding mechanisms behind...
Mathematical models of angiogenesis and fluid flow through the vasculature not only elucidate development networks but also transportation metabolites therapeutic drugs to cells. In present work, a meshless-based model is used simulate sprouting in response vascular endothelial growth factor (VEGF) concentrations. The combined with Radial Point Interpolation Method (RPIM), being area discretized considering an unorganized nodal cloud background mesh integration points, without predefined...