A5067947536- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Collagen: Extraction and Characterization
- Wound Healing and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Periodontal Regeneration and Treatments
- Angiogenesis and VEGF in Cancer
- Innovative Microfluidic and Catalytic Techniques Innovation
- Lower Extremity Biomechanics and Pathologies
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Graphene and Nanomaterials Applications
- Knee injuries and reconstruction techniques
- Retinal Diseases and Treatments
- Extracellular vesicles in disease
- Bone and Dental Protein Studies
- Pancreatic and Hepatic Oncology Research
- Microplastics and Plastic Pollution
- Pancreatic function and diabetes
- Hydrogels: synthesis, properties, applications
Universidad de Jaén
2014-2025
Universidad de Granada
2015-2025
Instituto de Investigación Biosanitaria de Granada
2018-2025
Andalusian Health Service
2021
Aarhus University
2017
Instituto de Investigación Biomédica de A Coruña
2009-2013
Complexo Hospitalario Universitario A Coruña
2009-2013
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2013
Hospital San Juan de la Cruz
2004
The use of decellularized extracellular matrix (dECM) as a biomaterial has been an important step forward for the development functional tissue constructs. In addition to tissues and organs, cell cultures are gaining lot attention alternative source dECM. this work, novel biomimetic hydrogel is developed based on dECM obtained from mesenchymal stem cells (mdECM) cartilage engineering. To end, seeded under specific culture conditions generate early chondrogenic (ECM) providing cues elements...
Biofabrication technologies with layer-by-layer simultaneous deposition of a polymeric matrix and cell-laden bioinks (also known as bioprinting) offer an alternative to conventional treatments regenerate cartilage tissue. Thermoplastic polymers, like poly-lactic acid, are easy print using fused modeling, the shape, mesh structure, biodegradation time, stiffness can be easily controlled. Besides some them being clinically approved, high manufacturing temperatures used in bioprinting...
In breast cancer (BC), the presence of stem cells (CSCs) has been related to relapse, metastasis, and radioresistance. Radiotherapy (RT) is an extended BC treatment, but not always effective. CSCs have several mechanisms radioresistance in place, some miRNAs are involved cellular response ionizing radiation (IR). Here, we studied how IR affects expression stemness different molecular subtypes. Exposition doses 2, 4, or 6 Gy affected their phenotype, functional characteristics, pluripotency...
Abstract Conventional in vitro cancer models do not accurately reproduce the tumor microenvironment (TME), so three-dimensional (3D)-bioprinting represents an excellent tool to overcome their limitations. Here, two multicellular tri-layered malignant melanoma (MM) composed by stem cells (CSCs) isolated from a MM established cell line or primary-patient derived line, fibroblasts, mesenchymal cells, and endothelial embedded within agarose-collagen type I hydrogel were bioprinted....
Geographic atrophy (GA) secondary to age-related macular degeneration is a common cause of blindness worldwide. Given the recent approval first therapy for GA, pegcetacoplan, we critically appraise methodological aspects phase 3 clinical trials published so far in this disease relation their design, analysis and interpretation. We reviewed some key attributes all GA available main public registry as 20 May 2023. The topics discussed included types endpoints, eligibility criteria, p-value...