A5108006275- Cancer therapeutics and mechanisms
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- Cardiomyopathy and Myosin Studies
- Mesenchymal stem cell research
- Biochemical and Molecular Research
- Congenital Heart Disease Studies
- CRISPR and Genetic Engineering
- Cancer Treatment and Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Effects of Exercise
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- Synthesis and Biological Evaluation
- Cancer Cells and Metastasis
- Congenital heart defects research
- Colorectal Cancer Treatments and Studies
- Tissue Engineering and Regenerative Medicine
- HIV/AIDS drug development and treatment
- Drug Transport and Resistance Mechanisms
- Chemical Synthesis and Analysis
- Angiogenesis and VEGF in Cancer
Universidad de Granada
2007-2016
Instituto de Investigación Biosanitaria de Granada
2007-2015
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2007-2012
Universidad de Jaén
2012
Weatherford College
2012
Medicina
2004-2006
Regenerative Medicine Institute
2006
University of Almería
1997
University of Turin
1997
Hospital Universitario Virgen de las Nieves
1992-1993
The CD133 antigen is a marker of radio- and chemo-resistant stem cell populations in glioblastoma (GBM). O6-methylguanine DNA methyltransferase (MGMT) enzyme related with temozolomide (TMZ) resistance. Our propose to analyze the prognostic significance promoter methylation protein expression MGMT homogenous group GBM patients uniformly treated radiotherapy TMZ. possible connection between these markers was also investigated.
Menopause status has been associated with weight gain and increased central adiposity. Obesity postural instability are related to an risk of falls. The purpose our study was analyze the association body fat distribution balance their correlation falls in postmenopausal women.A cross-sectional, observational conducted on 100 women aged 50 65 years at least 12 months amenorrhea. participants were divided into obese, overweight, normal-weight groups according mass index (BMI) android, uniform,...
The chemotherapeutic drug 5-FU is widely used in the treatment of a range cancers, but resistance to remains major clinical problem. Since defects mediators apoptosis may account for chemo-resistance, identification new targets involved 5-FU-induced main interest. We have identified ds-RNA-dependent protein kinase (PKR) as key molecular target induction human colon and breast cancer cell lines. PKR distribution activation, cytotoxic effects were analyzed during 5-FU/IFNα several lines with...
Pancreatic ductal adenocarcinoma is a deadly disease because of late diagnosis and chemoresistance. We aimed to find panel serum cytokines representing diagnostic predictive biomarkers for pancreatic cancer.A cytokine antibody array was performed simultaneously identify 507 in sera patients with cancer healthy controls. The nonparametric Mann-Whitney U test used pairwise compare the controls, pretreated patients, posttreated patients. Fold changes greater than or equal 1.5 less 1/1.5 were...
In the field of cancer therapy, lipid nanocapsules based on a core-shell structure are promising vehicles for delivery hydrophobic drugs such as docetaxel. The main aim this work was to evaluate whether docetaxel-loaded improved anti-tumor effect free docetaxel in breast cells. Three were synthesized by solvent displacement method. Cytotoxic assays evaluated carcinoma (MCF-7) cells treated sulforhodamine B colorimetric Cell cycle studied flow cytometry and Annexin V-FITC, apoptosis using...
Falls are one of the leading causes fractures and impaired quality life in elderly, they related to balance deficit fear falls. The purpose our study is evaluate predictors falls 50-65-year-old postmenopausal population.A prospective cohort was conducted on 96 women. Fear falling postural stability were assessed by using FES-I (Falls Efficacy Scale-International) a force platform, respectively. Fall frequency determined 12-month follow-up period. Multivariate logistic regression used...
Endothelial progenitor cells (EPC) represent a relatively rare cell population, and expansion of sufficient numbers remains challenge. Nevertheless, human adipose-derived stem (hASC) can be easily isolated possess the ability to differentiate into endothelial cells. Here, we propose isolation characterization multipotent endothelial-like (ME-LC) with capacity maintain their vascular properties for long periods. hASC were from lipoaspirates cultured through distinct consecutive culture stages...
Adult stem cells have an enormous potential for clinical use in regenerative medicine that avoids many of the drawbacks characteristic embryonic and induced pluripotent cells. In this context, easily obtainable human adipose-derived offer interesting option future strategies medicine. However, little is known about their repertoire differentiation capacities, how closely they resemble target primary tissues, safety issues associated with use. DNA methylation one most widely recognized...
The skeletal muscle protein alpha-actin was investigated in the serum of subjects with severe damage to assess its utility as a reliable and predictive marker damage.Serum samples were obtained from 33 healthy controls patients damage, defined by total creatine kinase value >500 IU/l (Rosalki method). Troponin I, troponin T, myoglobin concentrations determined immunoassay Western blot densitometry.The mean concentration 600.9 1968.51 ng/ml, respectively, statistically significant difference....