A5076607721- Nanoparticle-Based Drug Delivery
- Glioma Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Pharmacological Receptor Mechanisms and Effects
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Cancer Treatment and Pharmacology
- Algal biology and biofuel production
- Anatomy and Medical Technology
- Brain Metastases and Treatment
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Health and Medical Education
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- Microbial Natural Products and Biosynthesis
Universidad de Granada
2015-2025
Instituto de Investigación Biosanitaria de Granada
2016-2025
Aswan University
2024
Assiut University
2024
Siriraj Hospital
2024
Mahidol University
2024
University of Almería
2020-2023
Hospital Universitario Virgen de las Nieves
2023
Parque Tecnológico de la Salud
2017-2018
Andalusian Health Service
2018
Background The use of temozolomide (TMZ) has improved the prognosis for glioblastoma multiforme patients. However, TMZ resistance may be one main reasons why treatment fails. Although this frequently been linked to expression O6-methylguanine-DNA methyltransferase (MGMT) it seems that enzyme is not only molecular mechanism account appearance drug in patients as mismatch repair (MMR) complex, P-glycoprotein, and/or presence cancer stem cells also implicated. Methods Four nervous system tumor...
Temozolomide (TMZ), an oral alkylating prodrug which delivers a methyl group to purine bases of DNA (O6-guanine; N7-guanine and N3-adenine), is frequently used together with radiotherapy as part the first-line treatment high-grade gliomas. The main advantages are its high bioavailability (almost 100% although concentration found in cerebrospinal fluid was approximately 20% plasma TMZ), lipophilic properties, small size that confer ability cross blood-brain barrier. Furthermore, this agent...
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest mortality rates among all cancer types. Its delayed diagnosis precludes curative resection, thus most current therapies against PDAC are based on chemo- and radiotherapy. Unfortunately, these strategies insufficient to improve its poor prognosis. Despite advances made in chemotherapy (e.g. nab-paclitaxel gemcitabine), many patients with unable benefit from them due rapid development drug resistance. Currently, more than 165 genes...
The CD133 antigen is a marker of radio- and chemo-resistant stem cell populations in glioblastoma (GBM). O6-methylguanine DNA methyltransferase (MGMT) enzyme related with temozolomide (TMZ) resistance. Our propose to analyze the prognostic significance promoter methylation protein expression MGMT homogenous group GBM patients uniformly treated radiotherapy TMZ. possible connection between these markers was also investigated.
Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the standard pain preclinical studies, show parallels their response to analgesics basic mechanisms. Mice with periarticular injections complete Freund's adjuvant (CFA) ankles showed immune infiltration synovial membrane alterations, together pronounced grip deficits allodynia measured von Frey hairs. However, inflammation-induced lasted...
Neuron-immune interaction in the dorsal root ganglia (DRG) plays a pivotal role neuropathic pain development after nerve injury. Sigma-1 receptor (Sig-1R) is expressed by DRG neurons but its not fully understood. We investigated effect of peripheral Sig-1R on neuroinflammation spared (sciatic) injury (SNI) mice. Nerve induced decrease NeuN staining along with nuclear eccentricity and ATF3 expression injured DRG. was present all examined, SNI this translocated to periphery soma vicinity...
Sigma-1 (σ1) receptor antagonists are promising tools for neuropathic pain treatment, but it is unknown whether σ1 inhibition ameliorates the signs induced by nerve transection, in which pathophysiological mechanisms and response to drug treatment differ from other models. In addition, antagonism inflammatory through modulation of endogenous opioid system, this occurs during pain. We investigated effect on painful hypersensitivity associated with spared injury (SNI) model mice. Wild-type...
Paclitaxel (PTX), a drug widely used in lung cancer, has serious limitations including the development of peripheral neurotoxicity, which may lead to treatment discontinuation and therapy failure. The transport PTX large cationic liposomes could avoid this undesirable effect, improving patient's prognosis. was encapsulated with two different sizes, MLV (180-200 nm) SUV (80-100 nm). In both cases, excellent biocompatibility improved internalization antitumor effect were observed human mice...
Paclitaxel (PTX) is one of the drugs choice in treatment breast and lung cancer. However, its severe side effects, including mielosuppression, cardiotoxicity neurotoxicity, frequently cause to be discontinued. Solid lipid nanoparticles (NPs) glyceril tripalmitate (tripalmitin) loaded with PTX (Tripalm-NPs-PTX) modifications by addition hexa(ethylene glycol), β-cyclodextrin macelignan were developed. All NPs-PTX formulations displayed excellent hemocompatibility significantly enhanced...
The use of legumes as functional foods has gained increasing attention for the prevention and treatment so called non-communicable diseases that are highly prevalent worldwide. In this regard, biotechnological approaches enhancement legumes' nutritional value have been extensively employed. present study, process germination increased several parameters mung bean (Vigna radiata L.) functionality, including extract yield, total phenolic content in vitro antioxidant capacity. addition,...
Nannochloropsis gaditana is a microalga with interesting nutritional and functional value due to its high content of protein, polyunsaturated fatty acids, bioactive compounds. However, the hardness cell wall prevents accessibility these components. This work aimed study effect treatment increase fragility on bioavailability nutrients The antioxidant antiproliferative capacity extracts from treated untreated N. was assessed, profile compounds characterized. Furthermore, nutrient availability...