A5061466379- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Endometriosis Research and Treatment
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Uterine Myomas and Treatments
- Marine Toxins and Detection Methods
- Mitochondrial Function and Pathology
- Estrogen and related hormone effects
- Glycosylation and Glycoproteins Research
- Reproductive System and Pregnancy
- Menstrual Health and Disorders
- Proteoglycans and glycosaminoglycans research
- Neuroendocrine regulation and behavior
- Coenzyme Q10 studies and effects
- TGF-β signaling in diseases
- Bone Metabolism and Diseases
- Herpesvirus Infections and Treatments
- Geography and Education Methods
- Food Allergy and Anaphylaxis Research
- Cellular transport and secretion
- Critical Race Theory in Education
- Biochemical Acid Research Studies
- Pediatric Pain Management Techniques
Universidad de Granada
2012-2025
Instituto de Investigación Biosanitaria de Granada
2017-2025
Institute of Molecular Biotechnology
2020-2023
INCLIVA Health Research Institute
2020-2023
Harvard University Press
2022
Austrian Academy of Sciences
2020-2022
Parque Tecnológico de la Salud
2012-2018
Hospital Universitario Infantil San José
2018
Universidad del Valle
2011
Pro Persona
2011
Neural stem cells (NSCs) are regarded as a promising therapeutic approach to protecting and restoring damaged neurons in neurodegenerative diseases (NDs) such Parkinson's disease Alzheimer's (PD AD, respectively). However, new research suggests that NSC differentiation is required make this strategy effective. Several studies have demonstrated melatonin increases mature neuronal markers, which reflects into neurons. Nevertheless, the possible involvement of mitochondria effects during has...
Abstract Primary coenzyme Q 10 (CoQ ) deficiency is due to mutations in genes involved CoQ biosynthesis. The disease has been associated with five major phenotypes, but a genotype–phenotype correlation unclear. Here, we compare two mouse models genetic modification Coq9 gene ( Q95X and R239X ), their responses 2,4‐dihydroxybenzoic acid (2,4‐di HB ). mice manifest severe widespread fatal encephalomyopathy respond 2,4‐di increasing levels. In contrast, exhibit mild manifesting reduction CI +...
Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the standard pain preclinical studies, show parallels their response to analgesics basic mechanisms. Mice with periarticular injections complete Freund's adjuvant (CFA) ankles showed immune infiltration synovial membrane alterations, together pronounced grip deficits allodynia measured von Frey hairs. However, inflammation-induced lasted...
Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme de novo BH4 synthetic pathway, human single-nucleotide polymorphism studies, together with mouse genetic modeling, have demonstrated that decreased GCH1 leads both reduced pain. However, little known about regulation of Gch1 expression upon nerve injury whether this could be modulated as an analgesic...
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to drug-induced analgesia. The pathophysiological role this process is unknown. We aimed investigate whether reduces inflammatory pain through disinhibition endogenous opioidergic system in mice. selective antagonists BD-1063 and S1RA abolished mechanical thermal hyperalgesia mice with carrageenan-induced acute (3 h) inflammation. Sigma-1-mediated antihyperalgesia...
Visceral pain is very common and represents a major unmet clinical need for which current pharmacological treatments are often insufficient. Tetrodotoxin (TTX) potent neurotoxin that exerts analgesic actions in both humans rodents under different somatic conditions, but its effect has been unexplored visceral pain. Therefore, we tested the effects of systemic TTX viscero-specific mouse models chemical stimulation colon (intracolonic instillation capsaicin mustard oil) intraperitoneal...
Morphine induces peripherally μ-opioid-mediated antinociception to heat but not mechanical stimulation. Peripheral sigma-1 receptors tonically inhibit μ-opioid stimuli, it is unknown whether they modulate antinociception. We hypothesized that might play a role in the modality-specific peripheral antinociceptive effects of morphine and other clinically relevant agonists. Mechanical nociception was assessed mice with paw pressure test (450 g), unilateral hot plate (55 °C) test. Local...
The analgesic effects of sigma-1 antagonists are undisputed, but the agonists on pain not well studied. Here, we used a mouse model to show that administration dextromethorphan (a widely antitussive drug), PRE-084 standard ligand), and pridopidine selective drug being investigated in clinical trials for treatment neurodegenerative diseases) enhances PGE2-induced mechanical hyperalgesia. Superficial plantar incision induced transient weight-bearing asymmetry at early time points, mice...
Sigma-1 receptor antagonism increases the effects of morphine on nociceptive pain, even in morphine-tolerant animals. However, it is unknown whether these receptors are able to modulate antinociception and tolerance during inflammatory pain. Here we used a mouse model test modulation by selective sigma-1 antagonist S1RA (MR309), determining its effect tactile allodynia (von Frey filaments) grip strength deficits induced joint inflammation (a measure pain-induced functional disability),...
Dopamine receptor 2 agonists (D2-ags) have been shown to reduce the size of tumors by targeting aberrant angiogenesis in pathological tissue. Because this, use a D2-ag was inferred for endometriosis treatment. When assayed mouse models however, D2-ags cause shift immature vessels towards more mature phenotype but not significant reduction amount vascularization and lesions. These has raised concerns on whether antiangiogenic effects these compounds confer therapeutic value endometriosis. In...
No adequate treatment is available for painful urinary bladder disorders such as interstitial cystitis/bladder pain syndrome, and the identification of new urological therapeutic targets an unmet need. The sigma-1 receptor (σ1-R) modulates somatic pain, but its role in unexplored. urothelium expresses many receptors typical primary sensory neurons (e.g. TRPV1, TRPA1 P2X3) high levels σ1-R have been found these neurons; we therefore hypothesized that may also be expressed functional relevance...
The aim of this study was to develop and refine a heterologous mouse model endometriosis-associated pain in which non-evoked responses, more relevant the patient experience, were evaluated. Immunodeficient female mice (N = 24) each implanted with four endometriotic human lesions 12) or control tissue fat on abdominal wall using glue. Evoked responses measured biweekly von Frey filaments. Non-evoked recorded weekly for 8 weeks home cage analysis (
Mitochondria play a central role in the cell physiology. It is now recognized that, besides their classic function of energy metabolism, mitochondria are enrolled multiple functions including distribution through cell, energy/heat modulation, reactive oxygen species (ROS) regulation, calcium homeostasis, and apoptosis control. Recently, evidence accumulating for direct participation stem proliferation and/or differentiation. All these suggest that mutations either nuclear or mitochondrial...