A5055590905- Genomics and Chromatin Dynamics
- Glycosylation and Glycoproteins Research
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Proteoglycans and glycosaminoglycans research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Graphene and Nanomaterials Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- Cellular transport and secretion
- RNA Research and Splicing
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
- T-cell and B-cell Immunology
Institute for Biomedical Engineering
2023-2024
ETH Zurich
2023-2024
Austrian Academy of Sciences
2020-2022
Institute of Molecular Biotechnology
2020-2022
Generating 3D bone cell networks in vitro that mimic the dynamic process during early formation remains challenging. Here, we report a synthetic biodegradable microporous hydrogel for efficient of from human primary cells, analysis cell-secreted extracellular matrix (ECM) and microfluidic integration. Using polymerization-induced phase separation, demonstrate situ microporosity (5-20 µm) within metalloproteinase-degradable polyethylene glycol hydrogels presence living cells. Pore is...
The HUSH (human silencing hub) complex contains the H3K9me3 binding protein M-phase phosphoprotein 8 (MPP8) and recruits histone methyltransferase SETDB1 as well Microrchidia CW-type zinc finger 2 (MORC2). Functional mechanistic studies of have hitherto been centered around while in vivo functions MPP8 MORC2 remain elusive. Here, we show that genetic inactivation Mphosph8 or Morc2a nervous system mice leads to increased brain size, altered architecture, behavioral changes. Mechanistically,...
Jagunal homolog 1 (JAGN1) has been identified as a critical regulator of neutrophil biology in mutant mice and rare-disease patients carrying JAGN1 mutations. Here, we report that Jagn1 deficiency results alterations the endoplasmic reticulum (ER) antibody-producing cells well decreased antibody production secretion. Consequently, lacking B exhibit reduced serum immunoglobulin (Ig) levels at steady state fail to mount an efficient humoral immune response upon immunization with specific...
Abstract Generating 3D bone cell networks in vitro that accurately mimic the dynamic process of osteoblast embedding during early formation poses a significant challenge. Herein, we report synthetic biodegradable macroporous hydrogel for efficient from human primary cells, analysis cell-secreted extracellular matrix (ECM) and microfluidic integration. Using polymerization-induced phase separation, metalloproteinase-sensitive polyethylene glycol hydrogels are formed with interconnected...
ABSTRACT The brain extracellular matrix (ECM) is enriched in chondroitin sulphate proteoglycans (CSPGs) with variable modifications that intimately participate maturation and function. Very little known about how the changing biophysical properties of CSPGs are signalled to neurons. Here, we report Fibrinogen C Domain Containing 1 (FIBCD1), a chitin-binding receptor innate immune system, be highly expressed hippocampus specifically bind containing 4-O modification (CS-4S). Cultured Fibcd1...
Abstract Fine-tuning of neural connectivity is important for cerebral functions and brain evolution. Protocadherins provide barcodes neuronal identity as well synapse formation expansion protocadherin cluster genes has been linked to advanced cognitive functions. The tightly controlled stochastic combinatorial expression the different isoforms in individual neurons provides molecular basis diversity, network complexity function vertebrate brain. How protocadherins are epigenetically not yet...