A5042390848- Advanced MRI Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Mitochondrial Function and Pathology
- Micro and Nano Robotics
- Metabolism and Genetic Disorders
- Iron oxide chemistry and applications
- Atomic and Subatomic Physics Research
- Characterization and Applications of Magnetic Nanoparticles
- Soft Robotics and Applications
- Advanced NMR Techniques and Applications
- Nanoplatforms for cancer theranostics
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Magnetic Properties and Synthesis of Ferrites
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Diamond and Carbon-based Materials Research
- Genetic Neurodegenerative Diseases
- Amino Acid Enzymes and Metabolism
- Functional Brain Connectivity Studies
- Glioma Diagnosis and Treatment
- Wireless Power Transfer Systems
- Molecular Communication and Nanonetworks
- Iron Metabolism and Disorders
- Memory and Neural Mechanisms
Univerzitetski Klinički Centar Srbije
2025
Max Planck Institute for Intelligent Systems
2021-2024
Institute of Molecular Biotechnology
2022-2023
Vienna BioCenter Core Facilities
2018-2022
Vienna Biocenter
2018-2022
Austrian Academy of Sciences
2022
Institute for Biomedical Engineering
2021
ETH Zurich
2021
Carnegie Mellon University
2021
Campus Science Support Facilities
2016-2020
Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with life-threatening cerebral oedema and dysmyelination in affected individuals. Treatment requires life-long dietary restriction monitoring acids to avoid brain injury. Despite careful management, children commonly suffer metabolic decompensation the context catabolic stress associated non-specific illness. The mechanisms underlying this injury are poorly understood. Using recently...
Article7 August 2018Open Access Source DataTransparent process RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure Mamta Jain Corresponding Author [email protected] Division Cell Biology, Center for Anatomy Medical University Vienna, Austria Search more papers by this author Tomer D Mann The Mina Everard Goodman Faculty Life Sciences, Bar Ilan University, Ramat-Gan, Israel Tel Aviv Sourasky Center, Aviv, Maja Stulić Shailaja P Rao Molecular Medicine,...
Article24 June 2019Open Access Source DataTransparent process Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy Iris Uribesalgo Corresponding Author [email protected] orcid.org/0000-0001-9492-1000 Institute of Molecular Biotechnology the Austrian Academy Sciences (IMBA), Vienna BioCenter, Vienna, Austria Search for more papers by this author David Hoffmann Yin Zhang Department Microbiology, Tumor Cell Biology, Biomedicum, Karolinska Institutet,...
In the autosomal recessive human disease, glutaric aciduria type I (GA-1), glutaryl-CoA dehydrogenase (GCDH) deficiency disrupts mitochondrial catabolism of lysine and tryptophan. Affected individuals accumulate acid (GA) 3-hydroxyglutaric (3-OHGA) in serum often suffer acute striatal injury childhood. Prior attempts to produce selective vulnerability an animal model have been unsuccessful. We hypothesized that may be induced GCDH-deficient (Gcdh-/-) mice by elevated dietary protein lysine....
Abstract Controlled microrobotic navigation in the vascular system can revolutionize minimally invasive medical applications, such as targeted drug and gene delivery. Magnetically controlled surface microrollers have emerged a promising platform for circulatory system. Locomotion of micrororollers strong flow velocities is highly challenging task, which requires magnetic materials having actuation properties while being biocompatible. The L1 0 ‐FePt coating achieve requirements. Therefore,...
Catheters integrated with microcoils for electromagnetic steering under the high, uniform magnetic field within resonance (MR) scanners (3-7 Tesla) have enabled an alternative approach active catheter operations. Achieving larger ranges of tip motion Lorentz force-based previously been dependent on using high power coupled cooling, bulkier designs, or introducing additional microcoil sets along catheter. This work proposes a heat-mitigated design and actuation strategy imaging (MRI)-driven...
Excessive inflammation has been implicated in the progressive neurodegeneration that occurs multiple neurological diseases, including cerebral ischemia, and elevated levels of proinflammatory cytokine interleukin-1 (IL-1) have shown to exacerbate brain damage, whereas diminishing IL-1 limits extent injury. However, date there is no consensus regarding which receptor(s) mediates detrimental effects IL-1. Because we previously demonstrated signaling through type 1 receptor (IL-1R1) necessary...
Glutaric acidemia type I (GA-I) is an inherited disorder of lysine and tryptophan metabolism presenting with striatal lesions anatomically symptomatically similar to Huntington disease. Affected children commonly suffer acute brain injury in the context a catabolic state associated nonspecific illness. The mechanisms underlying age-dependent susceptibility have been unknown, lack diagnostic marker heralding has impeded intervention efforts. Using mouse model GA-I, we show that pathologic...
Despite early diagnosis, one-third of Amish infants with glutaryl-CoA dehydrogenase deficiency (GA1) develop striatal lesions that leave them permanently disabled. To better understand mechanisms degeneration, we retrospectively studied imaging results from 25 GA1 patients homozygous for 1296C>T mutations in GCDH. Asymptomatic had reduced glucose tracer uptake and increased blood volume throughout gray matter, which may signify a predisposition to brain injury. Nine children (36%) developed...
Background and Purpose— Interleukin-1 (IL-1) is a proinflammatory cytokine implicated in multiple neurodegenerative diseases, including stroke. However, to date, there no consensus regarding which receptor(s) mediates the detrimental effects of IL-1. We hypothesized that abrogating IL-1 type 1 receptor (IL-1R1) signaling would reduce edema, chemokine expression, leukocyte infiltration; lower levels iNOS; and, consequently, decrease free radical damage after mild hypoxia/ischemia (H/I), thus...
Nitroxoline is an FDA-approved antibiotic with potential antitumor activity. Here we evaluated whether nitroxoline has antiproliferative properties on glioma cell growth in vitro and vivo using lines a genetically engineered PTEN/KRAS mouse model. The effect of treatment U87 and/or U251 proliferation, cell-cycle arrest, invasion, ability to induce apoptotic cascade was determined vitro. Magnetic resonance imaging used measure volumes mice prior after therapy. Induction apoptosis by at the...
Abstract Using the sol-gel method we synthesized hematite ( α − Fe 2 O 3 ) nanoparticles in a silica matrix with 60 wt % of hematite. X-ray diffraction (XRD) patterns and Fourier transform infrared (FTIR) spectra sample demonstrate formation phase amorphous silica. A transmission electron microscopy (TEM) measurements show that consists two particle size distributions average sizes around 10 nm 20 nm, respectively. Magnetic properties were measured using superconducting quantum interference...
Translating medical microrobots into clinics requires tracking, localization, and performing assigned tasks at target locations, which can only happen when appropriate design, actuation mechanisms, imaging systems are integrated a single microrobot. Despite this, these parameters not fully considered designing macrophage-based microrobots. This study presents living that combine macrophages with magnetic Janus particles coated FePt nanofilm for steering bacterial lipopolysaccharides...
Magnetic resonance imaging and spectroscopy rely on the magnetic fields generated by radiofrequency volume coils to acquire high-quality data. Consequently, a comprehensive understanding of electromagnetic field behavior in RF is essential for optimizing techniques designing advanced coils. This study introduces theoretical model birdcage coil, based spherical geometry approach. To validate proposed model, phantom images were acquired at different resonant frequencies, produced coil was...
Background/Objectives: Functional seizures (FSs) are paroxysmal, time-limited events with motor, sensory, autonomic, or cognitive manifestations related to pathophysiological processes other than abnormal electric discharges in the brain. However, these often followed by different psychiatric comorbidities. Their impact on overall quality of life and cofounding factors, especially ones that can be treated, were main investigation aims this study. Methods: This study comprised 76 patients who...
The HUSH (human silencing hub) complex contains the H3K9me3 binding protein M-phase phosphoprotein 8 (MPP8) and recruits histone methyltransferase SETDB1 as well Microrchidia CW-type zinc finger 2 (MORC2). Functional mechanistic studies of have hitherto been centered around while in vivo functions MPP8 MORC2 remain elusive. Here, we show that genetic inactivation Mphosph8 or Morc2a nervous system mice leads to increased brain size, altered architecture, behavioral changes. Mechanistically,...
Abstract Nanodiamonds (ND) hold great potential for diverse applications due to their biocompatibility, non‐toxicity, and versatile functionalization. Direct visualization of ND by means non‐invasive imaging techniques will open new venues labeling tracking, offering unprecedented unambiguous detection labeled cells or nanodiamond‐based drug carrier systems. The structural defects in diamonds, such as vacancies, can have paramagnetic properties potentially act contrast agents magnetic...