A5060202809- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Cannabis and Cannabinoid Research
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Medical Education and Admissions
- Pharmaceutical Practices and Patient Outcomes
- Cancer Treatment and Pharmacology
- Peptidase Inhibition and Analysis
- Innovations in Medical Education
- Characterization and Applications of Magnetic Nanoparticles
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Muscle metabolism and nutrition
- Reproductive tract infections research
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Bio-sensing Technologies
- Drug Transport and Resistance Mechanisms
- GABA and Rice Research
- Proteins in Food Systems
- Doping in Sports
- Advanced MRI Techniques and Applications
- Cancer Research and Treatment
- MRI in cancer diagnosis
Universidad de Sevilla
2019-2024
Universidad de Granada
2015-2017
Damascus University
2008-2016
Weatherford College
2015
International University for Science and Technology
2013
Beatson West of Scotland Cancer Centre
2008
University of Glasgow
2008
University of Strathclyde
2004
Liposomes constitute the most exploited drug-nanocarrier with several liposomal drugs on market. Microfluidic-based preparation methods stand up as a promising approach high reproducibility and ability to scale up. In this study, liposomes composed of DOPC, cholesterol, DSPE-PEG 2000 different molar ratios were fabricated using microfluidic system. Process conditions optimized by applying design experiments (DoE) principles. Furthermore, data used build an artificial neural network (ANN)...
Hepatic mitochondrial dysfunction is thought to play a role in the development of liver steatosis and insulin resistance, which are both common characteristics obesity type 2 diabetes mellitus (T2DM). It was hypothesized that antioxidant properties melatonin could potentially improve impaired functions hepatic mitochondria diabetic obese animals. Male Zucker fatty (ZDF) rats lean littermates (ZL) were given either (10 mg/kg BW/day) orally for 6 wk (M-ZDF M-ZL) or vehicle as control groups...
The objective of these in vitro studies was to investigate the impact encapsulation three cannabis-based terpenes, namely β-myrcene (MC), β-caryophyllene (CPh), and nerolidol (NL), on their potential efficacy pain management. Terpene-encapsulated poly(ethylene glycol)-poly(lactic-co-glycolic acid) nanoparticles (PEG-PLGA NPs) were prepared by an emulsion-solvent evaporation method. terpene-loaded NPs examined HEK293 cells that express nociceptive transient receptor vanilloid-1 (TRPV1), ion...
A number of studies have examined the possibility delivering genes for treatment genetic diseases using various polymers and lipids. We previously demonstrated gene transfer ability amphiphilic (a soluble amine polymer covalently bound to lipid pendant groups). In current communication we explore activity glycol chitosans. Glycol chitosan was acid depolymerised give molecular weights. Palmitoyl or hexadecyl in some cases additional N-methyl quaternary ammonium groups were attached polymers....
<title>Abstract</title> Methotrexate successful therapy encounters various challenges in chemotherapy, such as poor oral bioavailability, low specificity, side effects and the development of drug resistances. In this study, we propose a dual-targeted nanocarrier comprising magnetite/chitosan nanoparticles for an efficient delivery. The synthesis particles was confirmed through morphological analysis using electron microscopy elemental mappings via energy dispersive X-ray spectroscopy. These...
Tegafur is used to treat various malignant lesions, including advanced gastric and colorectal cancers. However, its efficacy limited by low oral bioavailability, short half-life serious toxicity. To address these drawbacks, a nanoformulation of poly(ε-caprolactone) nanoparticles coated with chitosan was developed for the delivery Tegafur. Poly(ε-caprolactone) particles were prepared an interfacial polymer disposition method, while surface functionalization followed coacervation procedure....
This study aimed to assess pharmacy students’ knowledge about doping substances used in sport, explore their attitudes toward and investigate misuse of drugs. A questionnaire was developed employed collect data from bachelor (BPharm) students at the International University for Science Technology (IUST). Two-hundred eighty participated this self-administrated, paper-based survey. Around 90% did not appear know that narcotics, β-blockers diuretics were sport as agents. Additionally,...
Introduction: Paclitaxel (PTX) is a cornerstone in the treatment of breast cancer, most common type cancer women. However, this drug has serious limitations, including lack tissue-specificity, poor water solubility, and development resistance. The transport PTX polymeric nanoformulation could overcome these limitations. Methods: In study, PLGA-PTX nanoparticles (NPs) were assayed cell lines, stem cells (CSCs) multicellular tumor spheroids (MTSs) analyzing cycle, uptake (Nile Red-NR-)...
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