A5050623287- Bone health and treatments
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Vitamin D Research Studies
- Pancreatic and Hepatic Oncology Research
- Vestibular and auditory disorders
- Infectious Diseases and Tuberculosis
- Advanced Causal Inference Techniques
- Hearing Loss and Rehabilitation
- Immune Cell Function and Interaction
- Prostate Cancer Treatment and Research
- Cancer Risks and Factors
- Immune cells in cancer
- Women's cancer prevention and management
- Nursing Diagnosis and Documentation
- Cancer Immunotherapy and Biomarkers
- Hearing, Cochlea, Tinnitus, Genetics
- Orthopedic Infections and Treatments
- Phonocardiography and Auscultation Techniques
- Digital Radiography and Breast Imaging
- Cancer Cells and Metastasis
- Developmental and Educational Neuropsychology
- Aging, Health, and Disability
- Neuroscience, Education and Cognitive Function
Instituto de Investigación Biosanitaria de Granada
2010-2023
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
2012-2023
Hospital General Dr. Manuel Gea Gonzalez
2022
Universidad de Granada
1994-2021
Hospital Santa Caterina
2021
Institut d'Assistència Sanitària
2021
Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla
2019
Centro Tecnológico del Mar
2008
Immune-checkpoint inhibitors show encouraging results in cancer treatment, but the clinical benefit is limited exclusively to a subset of patients. We analyzed density and composition tumor T-cell infiltration non-small-cell lung carcinoma (NSCLC) relation PD-L1 HLA class I (HLA-I) expression. found that positive HLA-I expression, independently on status, key factor determining increased immune infiltrate. When both markers were simultaneously, we identified four phenotypes co-expression....
In breast cancer (BC), the presence of stem cells (CSCs) has been related to relapse, metastasis, and radioresistance. Radiotherapy (RT) is an extended BC treatment, but not always effective. CSCs have several mechanisms radioresistance in place, some miRNAs are involved cellular response ionizing radiation (IR). Here, we studied how IR affects expression stemness different molecular subtypes. Exposition doses 2, 4, or 6 Gy affected their phenotype, functional characteristics, pluripotency...
Breast cancer continues to be one of the main causes morbidity and mortality globally was leading cause death in women Spain 2020. Early diagnosis is most effective methods lower incidence rates breast cancer. The human metalloproteinases (MMP) mainly function as proteolytic enzymes degrading extracellular matrix plays important roles steps tumorigenesis. This retrospective cohort study shows immunohistochemical expression levels MMP-1, MMP-2, MMP-3, MMP-9 154 with 42 without tumor disease....
The El Niño event of 1997/1998 provided an opportunity to carry out a field experiment in which the relationship sea surface temperature and association Vibrio cholerae with marine plankton could be assessed Mexican coastal estuarine areas. Plankton samples were collected from May 1997 through June 1999. Sites included ports Veracruz, Coatzacoalcos Frontera Gulf Mexico Ensenada, Guaymas, Mazatlán, Manzanillo, Acapulco Oaxaca Pacific Ocean. Sampling was also accomplished during two...
Cancer eradication and clinical outcome of immunotherapy depend on tumor cell immunogenicity, including HLA class I (HLA-I) PD-L1 expression malignant cells, the characteristics microenvironment, such as immune infiltration stromal reaction. Loss HLA-I is a common mechanism escape from cytotoxic T lymphocytes linked to cancer progression resistance with inhibitors PD-L1/PD-1 signaling. Here we observed that loss in bladder tumors associated exclusion encapsulation elements rich FAP-positive...
Glucocorticoids (GCs) are the cornerstone of therapy in many autoimmune and inflammatory diseases. However, it is well known that their use a double edged sword, as beneficial effects associated almost universally with unwanted effects, as, for example glucocorticoid-induced osteoporosis (GIO). Over last years, several clinical practice guidelines emphasize need preventing bone mass loss reduce incidence fractures GC use. Calcium vitamin D supplementation, adjunctive therapy, included all...
Objective: To assess long-term effects of different hormone replacement therapy (HRT) regimens on mammographic density.Methods: One hundred sixty-five postmenopausal women were treated with the same HRT during 5 years: 38 received transdermal estradiol, 78 cyclic combined and 49 continuous therapy. Mammograms obtained at baseline, 1-year 5-year treatment. Breast density changes categorized as slight focal increased density, considerable diffuse density.Results: Mammographic in 7.9% receiving...
Discordant results about the relationship between diabetes complications and risk of fragility fractures have been reported. Our aims were to analyze factors related morphometric vertebral (VFs) in patients with type 2 mellitus, explore association presence VFs main cardiovascular factors.We carried out a cross-sectional study including 123 72 these we recorded data for comorbidities diabetes-related microvascular disease disease.In crude analysis, diabetic retinopathy (odds ratio [OR] 4.09,...
The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy prematurity.Between 2000 2017, 185 were included protocol for prematurity. Risk associated speed vascularization <0.5 disc diameter/week studied each them.The statistically significant variables related DD/w intubation days, degree 3 bronchopulmonary dysplasia, weight gain at 4-6 weeks, avascular temporal area, gestational age, number transfusions, sepsis,...
Objectives. To compare the effectiveness of postcesarean thromboprophylaxis with two different regimens bemiparin. Material and Methods. The study included 646 women cesarean delivery in our hospital within a 1-year period, randomly assigned to one groups for prophylaxis 3500 IU bemiparin once daily 5 days or 10 days. Results. There was case pulmonary embolism (first day following cesarean). An additional risk factor present 98.52% women, most frequently emergency cesarean, anemia, obesity....
The relationship between sex steroids and osteoprotegerin (OPG) in patients with prostate cancer is not well established. Our aim was to evaluate serum OPG levels its steroids, bone mineral density, turnover markers, fractures. We performed a cross-sectional study including 91 cancer. determined: density by dual-energy x-ray absorptiometry, of osteoprotegerin, prevalent radiographic vertebral Serum were higher fractures (8.02 ± 2.0 vs 4.91 0.28 pmol/L; P < .05). level the duration hormonal...
Visual memory can be defined as the ability to recall visual images in form of objects events or words. Previous neuropsychological research on Learning Disabilities (LD) involving has been focused particularly children who present nonverbal LD, and their scholar underachievement. Objective: This study aims develop a test using recognisable determine normative values validity population with LD control group. Methods procedures: A total 330 participated this (7-14 years), 190 suffered some...
Exocrine pancreatic insufficiency results from the destruction of parenchyma and is diagnosed by using direct or indirect tests, both which have shortcomings. Chronic pancreatitis most frequent cause this pathology in adults.Patients meeting radiological histological diagnostic criteria chronic are enrolled stool elastase test conducted, considering fecal levels >200 µg/g to represent normal function, <200 μg/g indicate presence exocrine insufficiency. Additionally, we determine body mass...