A5080657689- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Inflammasome and immune disorders
- RNA regulation and disease
- Retinoids in leukemia and cellular processes
- Retinopathy of Prematurity Studies
- Laser Applications in Dentistry and Medicine
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Skin Protection and Aging
- Neurobiology and Insect Physiology Research
- Retinal Imaging and Analysis
- Traumatic Brain Injury Research
- Atherosclerosis and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Complement system in diseases
- Intraocular Surgery and Lenses
- Heme Oxygenase-1 and Carbon Monoxide
- Immune responses and vaccinations
Australian National University
2017-2025
ACT Government
2018
Photoreceptor cell death and inflammation are known to occur progressively in retinal degenerative diseases, however the molecular mechanisms underlying these biological processes largely unknown. Extracellular vesicles (EV) essential mediators of cell-to-cell communication with emerging roles modulation immune responses. EVs including exosomes encapsulate transfer nucleic acids, microRNA (miRNA), recipient cells which disease may result dysfunctional responses a loss homeostatic regulation....
We sought to determine the role and retinal cellular location of microRNA-124 (miR-124) in a neuroinflammatory model degeneration. Further, we explored anti-inflammatory relationship miR-124 with predicted messenger RNA (mRNA) binding partner, chemokine (C-C motif) ligand 2 (Ccl2), which is crucially involved inflammatory cell recruitment damaged retina.Human AMD donor eyes photo-oxidative (PD) mice were labeled for expression using situ hybridization. PDGFRa-cre RFP used Müller isolation...
The role of the alternative complement pathway and its mediation by retinal microglia macrophages, is well-established in pathogenesis Age-Related Macular Degeneration (AMD). However, contribution classical towards progression degenerations not fully understood, including component 1q (C1q) as a critical activator molecule pathway. Here, we investigated C1q to progressive photoreceptor loss neuroinflammation degenerations.Wild-type (WT), C1qa knockout (C1qa-/-) mice treated with inhibitor...
Activation of the inflammasome is involved in progression retinal degenerative diseases, particular, pathogenesis Age-Related Macular Degeneration (AMD), with NLRP3 activation focus many investigations. In this study, we used genetic and pharmacological approaches to explore role a mouse model degeneration. We identify that Casp1/11
Introduction: MicroRNAs (miRNAs) are small, non-coding RNA molecules that have powerful regulatory properties, with the ability to regulate multiple messenger RNAs (mRNAs) and biological pathways. MicroRNA-223-3p (miR-223) is known be a critical regulator of innate immune response, its dysregulation thought play role in inflammatory disease progression. Despite miR-223 upregulation numerous neurodegenerative conditions, largely cells myeloid lineage, retina relatively unexplored. Here, we...
Although extensively investigated in inflammatory conditions, the role of pro-inflammatory microRNAs (miRNAs), miR-155 and miR-146a, has not been well-studied retinal degenerative diseases. We therefore aimed to explore regulation these miRNA degenerating retina, with a focus on miR-155. C57BL/6J mice were subjected photo-oxidative damage for up 5 days induce focal degeneration. MiR-155 expression was quantified by qRT-PCR whole serum, small-medium extracellular vesicles (s-mEVs), PrimeFlow™...
Abstract Background MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through their association with argonaute 2 (AGO2) - key member RNA Induced Silencing Complex (RISC). Identifying retinal miRNA/mRNA interactions health and disease will provide important insight into pathways miRNA regulate may lead to potential therapeutic targets mediate...
Sports-related concussion (SRC) is a common form of brain injury that lacks reliable methods to guide clinical decisions. MicroRNAs (miRNAs) can influence biological processes involved in SRC, and measurement miRNAs fluids may provide objective diagnostic return play/recovery biomarkers. Therefore, this prospective study investigated the temporal profile circulating miRNA levels concussed male female athletes.Pre-season baseline blood samples were collected from amateur Australian rules...
Abstract In the central nervous system (CNS), including in retina, neuronal‐to‐glial communication is critical for maintaining tissue homeostasis signal transmission, transfer of trophic factors, and modulation inflammation. Extracellular vesicle (EV)‐mediated transport molecular messages to regulate these processes has been suggested as a mechanism by which bidirectional between neuronal glial cells can occur. this work we employed multiomics integration investigate role EV pathways from...
Purpose: Glutathione-S-transferase omega 1-1 (GSTO1-1) is a cytosolic glutathione transferase enzyme, involved in glutathionylation, toll-like receptor signaling, and calcium channel regulation. GSTO1-1 dysregulation has been implicated oxidative stress inflammation, contributes to the pathogenesis of several diseases neurological disorders; however, its role retinal degenerations unknown. The aim this study was investigate modulating consequent inflammation normal degenerating retina....
1.1. Abstract Purpose Photoreceptor cell death and inflammation are known to occur progressively in retinal degenerative diseases, however the molecular mechanisms underlying these biological processes largely unknown. Extracellular vesicles (EV) essential mediators of cell-to-cell communication with emerging roles modulation immune responses. EVs including exosomes encapsulate transfer nucleic acids, microRNA (miRNA), recipient cells which disease may result dysfunctional responses a loss...
Summary MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases, including age-related macular degeneration, acting as post-transcriptional gene suppressors through their association with argonaute (AGO) protein family members. However, to understand disease, investigation into regulatory nature miRNA targets is required. To identify active-miRnome-targetome interactions degenerating retina, AGO2 HITS-CLIP was performed using mouse model retinal...
Age-related macular degeneration (AMD) is the leading cause of vision loss in developed world and detection its onset progression are based on retinal morphological assessments. MicroRNA (miRNA) have been explored extensively as biomarkers for a range neurological diseases including AMD, however differences experimental design complexity human biology resulted little overlap between studies. Using preclinical animal models clinical samples, this study employs novel approach to determine...