A5032026645- Glioma Diagnosis and Treatment
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Meningioma and schwannoma management
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Fungal and yeast genetics research
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Prostate Cancer Treatment and Research
- Neuroblastoma Research and Treatments
- Single-cell and spatial transcriptomics
- Biomedical Ethics and Regulation
- Pituitary Gland Disorders and Treatments
- Medical Imaging Techniques and Applications
Center for Neuro-Oncology
2018-2024
Dana-Farber Cancer Institute
2018-2024
NYU Langone Health
2024
Harvard University
2018-2024
Brigham and Women's Hospital
2017-2024
Columbia University
2011-2024
Boston University
2022-2023
Dana-Farber Brigham Cancer Center
2019-2021
Neurological Surgery
2019
University of Alabama at Birmingham
2019
Fluorescence loss in photobleaching experiments and analysis of mitochondrial function using superoxide redox potential biosensors revealed that mitochondria within individual yeast cells are physically functionally distinct. Mitochondria retained mother during cell division have a significantly more oxidizing higher levels compared to buds. Retention with occurs the same extent young older can account for age-associated decline total cellular as they age from 0 5 generations. Deletion...
Background Approximately one‐fourth of all cancer metastases are found in the brain. MRI is primary technique for detection brain metastasis, planning radiotherapy, and monitoring treatment response. Progress tumor now requires new or growing at small subcentimeter size, when these therapies most effective. Purpose To develop a deep‐learning‐based approach finding metastasis on MRI. Study Type Retrospective. Sequence Axial postcontrast 3D T 1 ‐weighted imaging. Field Strength 1.5T 3T....
PURPOSE The Response Assessment in Neuro-Oncology (RANO) criteria are widely used high-grade glioma clinical trials. We compared the RANO with updated modifications (modified [mRANO] and immunotherapy [iRANO] criteria) patients newly diagnosed glioblastoma (nGBM) recurrent GBM (rGBM) to evaluate performance of each set inform development planned 2.0 update. MATERIALS AND METHODS Evaluation tumor measurements fluid-attenuated inversion recovery (FLAIR) sequences were performed by blinded...
The Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT) is a phase II platform trial that uses response adaptive randomization and genomic profiling to efficiently identify novel therapies for III testing. Three initial experimental arms (abemaciclib [a cyclin-dependent kinase [CDK]4/6 inhibitor], neratinib [an epidermal growth factor receptor [EGFR]/human 2 CC-115 deoxyribonucleic acid-dependent protein kinase/mammalian target rapamycin inhibitor]) were...
Adverse clinical events cause significant morbidity in patients with GBM (GBM). We examined whether genomic alterations were associated AE (AE) GBM.
Abstract Background Targeted gene NGS testing is available through many academic institutions and commercial entities increasingly incorporated in practice guidelines for glioblastoma (GBM). This single-center retrospective study aimed to evaluate the clinical utility of incorporating results management GBM patients at a trials-focused center. Methods We identified 1011 consecutive adult with pathologically confirmed (IDHwt or IDHmut) who had somatic tumor sequencing (Oncopanel, ~500 cancer...
Journal Article Negative trials over and again: How can we do better? Get access J Ricardo McFaline-Figueroa, McFaline-Figueroa Center For Neuro-Oncology, Dana-Farber Cancer Institute, Boston, USADivision of Department Neurology, Brigham Women’s Hospital, USAHarvard Medical School, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Patrick Y Wen Corresponding Author: Y. Wen, MD, 450 Brookline Avenue, MA 02420, (patrick_wen@dfci.harvard.edu). Volume 25, Issue...
Abstract Despite major strides in cancer research and therapy, these advances have not been equitable across race ethnicity. Historically marginalized groups (HMG) are more likely to inadequate preventive screening, increased delays diagnosis, poor representation clinical trials. Notably, Black, Hispanic, Indigenous people represent 30% of the population but only 9% oncology trial participants. As a result, HMGs lack access novel therapies, contradicting principle distributive justice, as...
Loss of PTEN, the negative regulator PI3K activity, is frequent in glioblastomas (GBMs). However, role two major isoforms, p110α and p110β, PTEN-deficient gliomagenesis remains unknown. We show that GBM largely depends on for proliferation p110β migration. Genetic ablation either isoform delays tumor progression mice, but only ablating both isoforms completely blocks driven by concurrent Pten p53. BKM120 (buparlisib) treatment modestly prolongs survival mice bearing intracranial Pten/p53...
Abstract Background Glioblastoma (GBM) patients are treated with radiation therapy, chemotherapy, and corticosteroids, which can cause myelosuppression. To understand the relative prognostic utility of blood-based biomarkers in GBM its implications for clinical trial design, we examined incidence, predictors, value lymphopenia, neutrophil-to-lymphocyte ratio (NLR), platelet count during chemoradiation (CRT) recurrence. Methods This cohort study included 764 newly diagnosed glioblastoma from...
ABSTRACT OBJECTIVE This article discusses the diagnostic approach to patients with suspected neoplasms of spinal cord and reviews most common primary metastatic their presentations. LATEST DEVELOPMENTS Neoplasms are rare entities that can involve parenchyma, dura leptomeninges, or extradural space. The intramedullary tumors, including ependymomas, pilocytic astrocytomas, diffuse midline gliomas. spine intradural extramedullary meningiomas, whereas leptomeninges rare. Advances in molecular...
Glioblastoma is immunologically "cold" and resistant to single-agent immune-checkpoint inhibitors (ICI). Our previous study of neoadjuvant pembrolizumab in surgically-accessible recurrent glioblastoma identified a molecular signature response ICI suggested that may improve survival. To increase the power this observation, we enrolled an additional 25 patients with primary endpoint evaluating cell cycle gene associated performed bulk-RNA seq on resected tumor tissue (NCT02852655). Neoadjuvant...
Whole-brain radiotherapy (WBRT) in patients with brain metastases (BM) is associated neurocognitive decline. Given its crucial role learning and memory, efforts to mitigate this toxicity have mostly focused on sparing radiation the hippocampus. We hypothesized that BM are not evenly distributed across several additional areas may be avoided WBRT based a low risk of developing BM. contoured 2757 lesions large, single-institution database newly diagnosed centroids were mapped onto standard...
Abstract BACKGROUND The cyclin D-CDK4/6-Rb pathway is activated in most glioblastomas. Abemaciclib a potent CDK4/6 inhibitor with good brain penetration approved for ER/PR/HER2- breast cancer. In order to efficiently evaluate the potential impact of abemaciclib on overall survival (OS) newly diagnosed glioblastoma and simultaneously develop information regarding genomic biomarker associations, was included as an arm Individualized Screening Trial Innovative Glioblastoma Therapy (INSIGhT)...
The Saccharomyces cerevisiae strain CBS6412 has been shown to be able grow in synthetic medium containing glycerol as the sole carbon source, conditions under which laboratory strains such CEN.PK and S288c cannot grow. Nonetheless, this exhibits a lag phase of c. 30-40 h following transition medium. As mitochondria play critical role dissimilation respiratory source glycerol, we investigated mitochondrial function dynamics throughout using mitochondria-targeted roGFP, redox-sensitive GFP...
Abstract BACKGROUND EGFR is amplified in over 50% of glioblastoma and 20-30% have EGFRvIII mutations. Neratinib a potent inhibitor EGFR/HER2 approved for metastatic HER2+ breast cancer. To efficiently evaluate the potential impact neratinib on overall survival (OS) newly-diagnosed to simultaneously develop information regarding genomic biomarker associations, was included as an arm Individualized Screening Trial Innovative Glioblastoma Therapy (INSIGhT) trial. INSIGhT phase II platform trial...