A5029492095- Prostate Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- MRI in cancer diagnosis
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Optical Coherence Tomography Applications
- Epilepsy research and treatment
- Tracheal and airway disorders
- Pharmacological Effects and Toxicity Studies
- Photoacoustic and Ultrasonic Imaging
- Vascular Malformations Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Corneal surgery and disorders
- Gastrointestinal Tumor Research and Treatment
- Cell Adhesion Molecules Research
- Fetal and Pediatric Neurological Disorders
- Immune cells in cancer
Institut de Neurophysiopathologie
2024
Centre National de la Recherche Scientifique
2022-2024
Aix-Marseille Université
2024
Hôpital Cochin
2014-2023
Université Paris Cité
2013-2023
Assistance Publique – Hôpitaux de Paris
2011-2023
Pitié-Salpêtrière Hospital
2019
Sorbonne Université
2019
Délégation Paris 5
2010-2018
Délégation Paris 6
2009-2018
Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b What’s known on the subject? and What does study add? Dynamic contrast enhanced (DCE) diffusion weighted (DW) MRI have demonstrated their potential value in distinguishing malignant from benign prostate tissue, but none them used alone is capable optimally characterizing tumours prostate. The combination DW, DCE T2W imaging increased significantly performance for cancer detection peripheral zone. OBJECTIVE • To evaluate...
We compared the accuracy of visual targeted biopsies vs computerized transrectal ultrasound-magnetic resonance imaging registration using a rigid (Esaote®, nondeformable) or elastic (Koelis®, deformable) approach.A total 391 consecutive patients with suspected localized prostate cancer were prospectively included in analysis. All underwent magnetic imaging, followed by 10 to 12-core random biopsies. When detected suspicious findings, biopsy was performed, including visual, system and first...
<h3>Objective:</h3> To determine the diagnostic accuracy and prognostic value of <sup>18</sup>FDG-PET in a recent series patients operated for intractable partial epilepsy associated with histologically proven Taylor-type focal cortical dysplasia (TTFCD) negative MRI. <h3>Methods:</h3> Of 23 consecutive (12 male, 7–38 years old) 1.5-Tesla MRI, 10 exhibited subtle nonspecific abnormalities (e.g., unusual sulcus depth or gyral pattern) 13 others had strictly normal FDG-PET was analyzed both...
Journal Article Anti-Colony-Stimulating Factor-1 Antibody Staining in Primary Breast Adenocarcinomas Correlates With Marked Inflammatory Cell Infiltrates and Prognosis Get access S. M. Scholl, Scholl Département de Médecine Oncolo-gique, Institut CurieParis Correspondence to : M.D.: Départment Oncologique, Curie, 26 rue d, Ulm, 75231 Paris Cedex 05, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Pallud, Pallud Laboratoire d'Oncogénétique et...
Objectives Endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) using standard needles has a high diagnostic value in the evaluation of solid pancreatic masses. Fenestrated have been developed to improve quality EUS‐guided tissue sampling by providing core biopsies (FNB). Methods Patients with masses >2 cm were prospectively included our study and randomized receive EUS sampling, either 22G FNA or Procore® FNB needle. The main endpoint was number needle passes required obtain...
We determined whether endorectal multiparametric magnetic resonance imaging at 1.5 Tesla could predict tumor target volume in the perspective of focal therapy prostate cancer.A total 84 consecutive patients underwent before radical prostatectomy. The each suspicious area detected on and all surgical histological foci was by planimetry. first used sequence (T2-weighted, diffusion weighted dynamic contrast enhanced) then showing largest (multiparametric volume). Finally, any to calculate a...
Magnetic resonance imaging-transrectal ultrasound fusion targeted prostate biopsies were suggested to detect significant cancer with more accuracy than systematic biopsies. In this study we evaluate the pathological characteristics of multiparametric magnetic imaging detected and undetected tumor foci on radical prostatectomy specimens.We selected 125 consecutive patients treated for clinically localized diagnosed biopsy and/or biopsy. On each suspicious area was graded according PI-RADS...
Abstract Infiltrating immune cells in 30 primary human epithelial breast tumours were studied using specific anti‐CD3 (T cells), anti‐CD68 (macrophages), anti‐CD57 (NK and an anti‐pan‐B cell antibody (L26). The majority of tumour infiltrating inflammatory are T (40‐50%) monocytes/macrophages (15–35%). macrophage chemo‐attractant growth factor CSF‐1 is detected by immunohistochemical techniques (IHC) at the level invasive cancer 46/50 but not in‐ situ (pre‐invasive) cancer. A mosaic staining...
Abstract Solid‐pseudopapillary neoplasms (SPNs) are rare human pancreatic usually associated with a good prognosis. In contrast to other tumours, aberrant activation of the Wnt–β‐catenin pathway appears be constant feature in SPN. Aside from pathway, little is known about biological pathways deregulated We carried out transcriptome profiling SPN gain insights into pathogenesis these tumours. As expected, over‐expression AXIN2, TBX3, SP5 and NOTUM demonstrated β‐catenin pathway. Members Notch...
Summary Purpose: Polymicrogyria (PMG) is recognized as an epileptogenic lesion but few data concerning organization of the zone (EZ) are available. Methods: We analyzed distribution EZ according to Stereo‐EEG (SEEG) with intralesional recordings in four patients evaluated for intractable partial epilepsy associated focal unilateral PMG, involving posterior temporal region two, perisylvian area one and temporoparietal junction other. All had ictal scalp EEG, high‐resolution structural...
Abstract One hundred six primary breast cancer samples were analysed for c‐erbB2, int‐2, and c‐myc gene amplification. Surgically confirmed nodal involvement was observed in 42%. Level of amplification studied by Southern and/or slot blottechniques. Amplified c‐erbB2 sequences present 21.5% all samples. Int‐2 amplified 13.1% 10.3%. In a non‐parametric test (Kruskal‐Wallis) strong negative association found between high levels absence estrogen receptor (ER) ( P = .0009) or progesterone (PR)...
This study evaluated the accuracy of a new stereotactic CT‐guided brain biopsy (SCTGBB) device on 23 client‐owned dogs which presented with lesion. Biopsy lesion was achieved in 95 per cent cases. The target tissue not sampled one dog. Complications were observed six dogs. Two highly vascularised brainstem tumours died after SCTGBB. Minor complications (slight variation neurological status) further four A diagnosis reached 16 cytological examination and 21 histological evaluation. SCTGBB is...
The blood-brain barrier (BBB) permeabilities of 11 compounds were measured both in vitro with a newly developed coculture-based model human BBB and vivo positron emission tomography (PET). fluoropyridinyl derivatives labeled the positron-emitter fluorine-18, [<sup>18</sup>F]F-A-85380 [2-[<sup>18</sup>F]fluoro-3-[2(<i>S</i>)-2 azetidinylmethoxy]pyridine], 10 selected <i>N</i>-substituted-azetidinyl pyrrolidinyl closely related [<sup>18</sup>F]fluoropyridinyl (including...
We evaluated the accuracy of prostate magnetic resonance imaging- transrectal ultrasound targeted biopsy for Gleason score determination.We selected 125 consecutive patients treated with radical prostatectomy a clinically localized cancer diagnosed on imaging-transrectal and/or systematic biopsy. On multiparametric imaging each suspicious area was graded according to PI-RADS™ score. A correlation analysis between and pathological findings performed. Factors associated determining were...