A5053067095- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- stochastic dynamics and bifurcation
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Muscle activation and electromyography studies
- Diamond and Carbon-based Materials Research
- CCD and CMOS Imaging Sensors
- Neural Networks and Applications
- Nonlinear Dynamics and Pattern Formation
- Conducting polymers and applications
- Memory and Neural Mechanisms
- Animal Vocal Communication and Behavior
- Neurobiology and Insect Physiology Research
- Face Recognition and Perception
- Functional Brain Connectivity Studies
- Analytical Chemistry and Sensors
- Retinal and Macular Surgery
- Cell Image Analysis Techniques
The University of Melbourne
2016-2025
Vision Australia
2015-2024
Australian College of Optometry
2015-2022
O'Brien Institute
2022
ARC Centre of Excellence for Integrative Brain Function
2015-2019
Data61
2008-2018
Australian Research Council
2016-2017
National Ageing Research Institute
2015
Bionics Institute
2003-2012
Bernstein Center for Computational Neuroscience Munich
2009
Diamond is well known to possess many favourable qualities for implantation into living tissue including biocompatibility, biostability, and some applications hardness. However, conducting diamond has not, date, been exploited in neural stimulation electrodes due very low electrochemical double layer capacitance values that have previously reported. Here we present characterization of ultra-nanocrystalline grown the presence nitrogen (N-UNCD) exhibit charge injection capacity as high 163 µC...
A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling propagating waves visual cortex Alain Destexhe A3 Dynamics and biomarkers mental disorders Mitsuo Kawato F1 Precise recruitment spiking output at theta frequencies requires dendritic h-channels multi-compartment models oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods reconstruction current sources from extracellular...
This paper presents a complete 256-electrode retinal prosthesis chip, which is small and ready for packaging implantation. It contains 256 separate programmable drivers dedicated to electrodes flexible stimulation. A 4-wire interface employed power data transmission between the chip driving unit. Power forward are recovered from 600 kHz differential signal, while backward sent at 100 kbps rate simultaneously. The stimulator possesses many stimulation features, supporting various strategies....
Recently, there has been interest in investigating diamond as a material for use biomedical implants. Diamond can be rendered electrically conducting by doping with boron or nitrogen. This led to inclusion of doped and nitrogen included elements electrodes and/or feedthroughs medical As these conductive device are not encapsulated, is need establish their clinical safety article compares the biocompatibility (BDD) films insulating poly crystalline against silicone negative control BDD sample...
Retinal implants restore a sense of vision, for growing number users worldwide. Nevertheless, visual acuities provided by the current generation devices are low. The quantity information transferable to retina using existing implant technologies is limited, far below receptor cells' capabilities. Many agree that increasing density deliverable retinal prosthesis requires with stimulation electrodes both dense and numerous. This work describes new prostheses capable upscaling conveyable...
Extracellular spikes recorded in the visual cortex (Area 17/18, V1) are commonly classified into either regular-spiking (RS) or fast-spiking (FS). Using multi-electrode arrays positioned cat V1 and a broadband stimulus, we show that there is also distinct class with positive-spiking (PS) waveforms. PS units were associated mainly non-oriented receptive fields while RS FS had orientation-selective fields. We suggest recordings of axons originating from thalamus. This conclusion was reinforced...
Experimental evidence indicates that synaptic modification depends on the timing relationship between presynaptic inputs and output spikes they generate. In this letter, results are presented for models of spike-timing-dependent plasticity (STDP) whose weight dynamics is determined by a stable fixed point. Four classes STDP identified basis time extent their input-output interactions. The effect potentiation synapses with different rates input investigated to elucidate classical studies...
In order to develop retinal implants with a large number of electrodes, it is necessary ensure that they do not cause damage the neural tissue by heat electrical circuits generate. Knowledge amount power induces thermal will assist in development budgets for implants, which has significant effect upon design prostheses circuitry. this study, temperatures were measured at multiple locations on retina while was heated cadaver and vivo preparations using variety prosthesis implantation sites. A...
Neuroprosthetic devices, such as cochlear and retinal implants, work by directly stimulating neurons with extracellular electrodes. This is commonly modeled using the cable equation an applied voltage. In this paper a framework for modeling electrical stimulation presented. To end, cylindrical neurite confined space in subthreshold regime three-dimensional space. Through harmonic expansion of Laplace's equation, we derive spatio-temporal equations governing different modes stimulation,...
Orientation selectivity is a prominent feature of neurons in the mammalian primary visual cortex (V1), yet its emergence along pathway varies across species. In carnivores and primates, with elongated orientation-selective receptive fields (RFs) emerge V1, whereas mice such RFs appear earlier, retina or dorsal lateral geniculate nucleus (dLGN). Here, we investigate RF properties dLGN marsupial, wallaby ( Macropus eugenii) (N=2; Males), using multi-channel electrodes nonlinear input model...
Implantable electrode arrays are widely used in therapeutic stimulation of the nervous system (e.g. cochlear, retinal, and cortical implants). Currently, most neural prostheses use serial (i.e. one at a time) despite this severely limiting repertoire stimuli that can be applied. Methods to reliably predict outcome multi-electrode have not been available. Here, we demonstrate linear-nonlinear model accurately predicts responses arbitrary patterns using vitro recordings from single retinal...
This work was produced as part of the activities FAPESP Research, Disseminations and Innovation Center for Neuromathematics (grant 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR partially supported a CNPq 306251/2014-0).
Objective. Retinal prosthetic devices hold great promise for the treatment of retinal degenerative diseases such as retinitis pigmentosa and age-related macular degeneration. Through electrical stimulation surviving neurons, these evoke visual signals that are then relayed to brain. Currently, prostheses used in clinical trials have few electrodes, thus limiting acuity. Electrode arrays with high electrode densities been developed using novel technologies, including diamond growth laser...
ON and OFF retinal ganglion cells (RGCs) are known to have non-monotonic responses increasing amplitudes of high frequency (2 kHz) biphasic electrical stimulation. That is, an increase in stimulation amplitude causes the cell's spike rate up a peak value above which further increases cause cell decrease its activity. The response for occurs at different amplitudes, allows differential these functional types. In this study, we investigate mechanisms underlying brisk-transient RGCs their...
Abstract A central transformation that occurs within mammalian visual cortex is the change from linear, polarity-sensitive responses to nonlinear, polarity-insensitive responses. These neurons are classically labelled as either simple or complex, respectively, on basis of their response linearity (Skottun et al., 1991). While difference between cell classes clear when stimulus strength high, reducing diminishes differences types and causes some complex cells respond (Crowder 2007; van Kleef...