A5034057031- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Visual perception and processing mechanisms
- Robotics and Automated Systems
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Neuroscience, Education and Cognitive Function
- Artificial Intelligence in Healthcare
Champalimaud Foundation
2025
New York University
2018-2023
Bilkent University
2022
Inserm
2016-2017
Institut de Neurobiologie de la Méditerranée
2016-2017
Aix-Marseille Université
2016
The chained activation of neuronal assemblies is thought to support major cognitive processes, including memory. In the hippocampus, this observed during population bursts often associated with sharp-wave ripples, in form an ordered reactivation neurons. However, organization and lifetime these remain unknown. We used calcium imaging map patterns synchronous CA1 region awake mice runs on a treadmill. were composed recurring anatomically intermingled, but functionally orthogonal, assemblies....
This work was produced as part of the activities FAPESP Research, Disseminations and Innovation Center for Neuromathematics (grant 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR partially supported a CNPq 306251/2014-0).
The hippocampus plays a critical role in episodic memory: the sequential representation of visited places and experienced events. This function is mirrored by hippocampal activity that self organizes into sequences neuronal activation integrate spatiotemporal information. What are underlying mechanisms such integration still unknown. Single cell was recently shown to combine time distance information; however, it remains unknown whether degree tuning between space can be defined at network...
Abstract Sensory-guided behavior requires reliable encoding of information (from stimuli to neural responses) and flexible decoding responses behavior). In typical decision tasks, a small subset cells within large population encode task-relevant stimulus need be identified by later processing stages for relevant transmitted. A statistically optimal decoder (e.g., maximum likelihood) can utilize any given task configuration, but relies on complete knowledge the relationship between...
Sensory-guided behavior requires reliable encoding of stimulus information in neural populations, and flexible, task-specific readout. The former has been studied extensively, but the latter remains poorly understood. We introduce a theory for adaptive sensory processing based on functionally-targeted stochastic modulation. show that responses neurons area V1 monkeys performing visual discrimination task exhibit low-dimensional, rapidly fluctuating gain modulation, which is stronger...
Abstract Sensory-guided behavior requires reliable encoding of stimulus information in neural populations, and task-specific readout through a selective combination these responses. The former has been the topic extensive study, but means by which brain achieves latter remain poorly understood, especially when adapting to changing task demands. Here we introduce novel theory for adaptive sensory processing based on functionally-targeted stochastic modulation. We find that responses neurons...
Brain representations must strike a balance between generalizability and adaptability. Neural codes capture general statistical regularities in the world, while dynamically adjusting to reflect current goals. One aspect of this adaptation is stochastically co-modulating neurons' gains based on their task relevance. These fluctuations then propagate downstream guide decision-making. Here, we test computational viability such scheme context multi-task learning. We show that fine-tuning...
Abstract The hippocampus plays a critical role in episodic memory: the sequential representation of visited places and experienced events. This function is mirrored by hippocampal activity that self organizes into sequences neuronal activation integrate spatio-temporal information. What are underlying mechanisms such integration still unknown. Single cell was recently shown to combine time distance information; however, it remains unknown whether degree tuning between space can be defined at...