A5035193391- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Neuroethics, Human Enhancement, Biomedical Innovations
- Advanced Memory and Neural Computing
- Embodied and Extended Cognition
- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Advanced Electron Microscopy Techniques and Applications
- Neural Networks and Applications
- Advanced Fluorescence Microscopy Techniques
- Philosophy and Theoretical Science
- Cell Image Analysis Techniques
- Neuroscience, Education and Cognitive Function
- Electron and X-Ray Spectroscopy Techniques
- Reinforcement Learning in Robotics
- Machine Learning and Data Classification
- Digital Accessibility for Disabilities
- Genetics, Aging, and Longevity in Model Organisms
- E-Learning and Knowledge Management
- Cognitive Science and Mapping
- Olfactory and Sensory Function Studies
ACT Foundation
2014-2025
Voxiva (United States)
2022-2024
Brain Research Foundation
2022
Vrije Universiteit Amsterdam
2009-2013
Carbon180
2012-2013
Tecnalia
2009-2010
Amsterdam Neuroscience
2009
Boston University
2003-2008
University of New Hampshire
2005
McGill University
1999
Acetylcholine may regulate working memory for novel stimuli by activating intrinsic mechanisms sustained spiking in entorhinal cortical neurons, which have been demonstrated slice preparations of the cortex. Computational modeling demonstrates that loss cholinergic activation activity could selectively impair stimuli, whereas familiar be maintained because previously modified synapses. Blockade muscarinic receptors and selective lesions has shown to encoding delayed matching tasks. However,...
Affective Brain-Computer Interfaces (BCI) are systems that measure signals from the peripheral and central nervous system, extract features related to affective states of user, use these adapt human-computer interaction (HCI). BCIs provide new perspectives on applicability BCIs. may serve as assessment tools adaptive for HCI general population prove be especially interesting people with severe motor impairment. In this context, will enable simultaneous expression affect content, thus...
Serial section transmission electron microscopy (TEM) has proven to be one of the leading methods for millimeter-scale 3D imaging brain tissues at nanoscale resolution. It is important further improve efficiency acquire larger and more volumes. We report here a threefold increase in speed TEM by using beam deflecting mechanism enable highly efficient acquisition multiple image tiles (nine) each motion mechanical stage. For areas, duty cycle doubles than 30%, yielding net average rate 0.3...
The human brain can be understood as a vast network of neurons connected via synapses, the state which is characterized by ion concentrations, phosphorylation patterns, receptor densities, etc. It plausible that mechanistic simulation at scale whole (a “whole-brain emulation“ or WBE) will made, raising questions about moral status and personal agency. Creating dynamical model presents complex tradeoff between better performance, data collection operating costs. To make informed scientific,...
Persistent neuronal firing has been modeled in relation to observed brain rhythms, especially theta oscillations recorded behaving animals. Models of short-term memory that are based on such persistent properties specific neurons can meet the requirements spike-timing–dependent potentiation synaptic strengths during encoding a temporal sequence spike patterns. We show spiking buffer be simulated with integrate-and-fire include leak current even when different numbers spikes represent...
The orbital frontal cortex appears to be involved in learning the rules of goal-directed behavior necessary perform correct actions based on perception accomplish different tasks. activity orbitofrontal neurons changes dependent upon specific task or goal involved, but functional role this performance tasks has not been fully determined. Here we present a model prefrontal function using networks integrate-and-fire arranged minicolumns. This network forms associations between representations...
Whole brain emulation aims to re-implement functions of a mind in another computational substrate with the precision needed predict natural development active states as much influence random processes allows. Furthermore, does not present possible model function, but rather presents actual implementation that based on details circuitry specific brain. We introduce notation for representations state, transition and update functions, which elements their relations must be quantified accordance...
Abstract Serial section transmission electron microscopy (TEM) has proven to be one of the leading methods for millimeter-scale 3D imaging brain tissues at nanoscale resolution. It is important further improve efficiency acquire larger and more volumes. We report here a three fold increase in speed TEM by using beam deflecting mechanism enable highly efficient acquisition multiple image tiles (nine) each motion mechanical stage. For areas, duty cycle doubles than 30%, yielding net average...
Whole brain emulation aims to re-implement functions of a mind in another computational substrate by carefully emulating the function fundamental components, and copying connectivity between those components. The precision with which this is done must enable prediction natural development active states. To accomplish this, vivo measurements at large scale high resolution are critically important. We propose set requirements for these empirical measurements. then outline general methods...
Mind uploading speculation and debate often concludes that a procedure described as gradual in-place replacement preserves personal identity while destructive scan-and-copy produces some other in the target substrate such is lost along with biological brain. This paper demonstrates chain of reasoning establishes metaphysical equivalence between these two methods terms preserving identity.
OPINION article Front. Syst. Neurosci., 08 October 2014 Volume 8 - | https://doi.org/10.3389/fnsys.2014.00189