Arianna Dorschel
A5051522729- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Toxin Mechanisms and Immunotoxins
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Renal and related cancers
- Ginseng Biological Effects and Applications
- Functional Brain Connectivity Studies
- Neuroscience, Education and Cognitive Function
- RNA modifications and cancer
- Genetic and Kidney Cyst Diseases
University of St Andrews
2019-2022
ETH Zurich
2022
Brigham and Women's Hospital
2020
Harvard University
2020
In cervical cancer chemotherapy, paclitaxel (PTX) chemoresistance has become a major difficulty, and it also affects the survival rate of numerous tumor patients. Thus, for reversal chemoresistance, is imperative to develop combinatory drugs with petite or almost no side effects sensitize cells paclitaxel. Ginsenoside Rg5 (GRg5) may act as chemosensitizer by reversing multidrug resistance. The present study aimed determine potential GRg5 in PTX-resistant human adeno-carcinoma cell lines...
Abstract C-C chemokine receptor type 5 (CCR5) serves as a co-receptor for Human immunodeficiency virus (HIV), enabling the to enter human CD4 T cells and macrophages. In absence of CCR5, HIV strains that require CCR5 (R5 or M-tropic HIV) fail successfully initiate infection. Various natural mutations gene have been reported interfere with HIV-CCR5 interaction, which influences rate AIDS progression. Genetic characterization in individuals from National Capital Regions (NCRs) India revealed...
Abstract The cell cycle is a fundamental process in eukaryotic biology and accordingly controlled by highly conserved core signaling cascade. However, whether recently evolved proteins also influence this unclear. Here, we systematically map the of evolutionarily recent transcription factors (TFs) on human progression. We find that genomic targets select young TFs, many which belong to rapidly evolving Krüppel-associated box (KRAB) zinc-finger (KZFP) family, exhibit synchronized expression....