A5029829754- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- stochastic dynamics and bifurcation
- Photoreceptor and optogenetics research
- Neuroscience and Music Perception
- Neural Networks and Applications
- Advanced Memory and Neural Computing
- Neuroscience, Education and Cognitive Function
- Visual perception and processing mechanisms
- Neural and Behavioral Psychology Studies
- Receptor Mechanisms and Signaling
- Musculoskeletal pain and rehabilitation
- Multisensory perception and integration
- Pain Mechanisms and Treatments
- Nonlinear Dynamics and Pattern Formation
- Zebrafish Biomedical Research Applications
- Memory and Neural Mechanisms
- Tactile and Sensory Interactions
- Transcranial Magnetic Stimulation Studies
- Spine and Intervertebral Disc Pathology
- Gaze Tracking and Assistive Technology
Aix-Marseille Université
2023-2025
Inserm
2015-2025
Institut de Neurobiologie de la Méditerranée
2024
Janelia Research Campus
2017-2023
Howard Hughes Medical Institute
2017-2022
École Normale Supérieure - PSL
2015
University of Geneva
2014-2015
École Normale Supérieure
2015
Unit of Neuroscience Information and Complexity
2013
Abstract The fact that feed-forward and top-down propagation of sensory information use distinct frequency bands is an appealing assumption for which evidence remains scarce. Here we obtain human depth recordings from two auditory cortical regions in both hemispheres, while subjects listen to sentences, show travels each direction using separate channels. Bottom-up dominates γ - δ – β (<40 Hz) bands, respectively. predominance low frequencies transfer confirmed by cross-regional coupling,...
Many environmental stimuli present a quasi-rhythmic structure at different timescales that the brain needs to decompose and integrate. Cortical oscillations have been proposed as instruments of sensory de-multiplexing, i.e., parallel processing frequency streams in signals. Yet their causal role such process has never demonstrated. Here, we used neural microcircuit model address whether coupled theta-gamma oscillations, observed human auditory cortex, could underpin multiscale analysis...
Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice expression of the autism/intellectual disability gene, Syngap1, cortical excitatory neurons is formation somatomotor networks promote SMI-mediated perception. Cortical Syngap1 was necessary and sufficient setting tactile sensitivity, sustaining object exploration, promoting learning. Mice with deficient...
Recent psychophysics data suggest that speech perception is not limited by the capacity of auditory system to encode fast acoustic variations through neural γ activity, but rather time given brain decode them. Whether decoding process bounded θ rhythm follow syllabic rhythms in speech, or constrained a more endogenous top-down mechanism, e.g., involving β unknown. We addressed dynamics comprehension challenging syllable tracking and using comprehensible incomprehensible time-compressed...
The density and overlap of cortical axons in the dorsolateral striatum (DLS) have suggested that striatal neurons integrate widespread information from regions are functionally related. However, vivo, DLS neuronal responses to sensory stimuli shown unexpectedly high selectivity, raising questions about actual degree input convergence functional corticostriatal projection on individual cells. Here, we investigated this question by focusing projections different whisker columns, as they...
Abstract Flexible control of motor timing is crucial for behavior. Before volitional movement begins, the frontal cortex and striatum exhibit ramping spiking activity, with variable ramp slopes anticipating onsets. This activity in cortico-basal ganglia loop may function as an adjustable ‘timer,’ triggering actions at desired timing. However, because share similar dynamics are both necessary behaviors, distinguishing their individual roles this timer remains challenging. To address this, we...
The activity of single neurons encodes behavioral variables, such as sensory stimuli (Hubel & Wiesel 1959) and choice (Britten et al. 1992; Guo 2014), but their influence on behavior is often mysterious. We estimated the a unit neural from recordings in anterior lateral motor cortex (ALM) mice performing memory-guided movement task (H. K. Inagaki 2018). Choice selectivity grew it flowed through sequence directions space. Early carried little were predicted to have large influence, while late...
Abstract Short-term memories link events separated in time, such as past sensation and future actions. are correlated with selective persistent activity, which can be maintained over seconds. In a delayed response task that requires short-term memory, neurons mouse anterior lateral motor cortex (ALM) show activity instructs To elucidate the mechanisms underlying this we combined intracellular extracellular electrophysiology optogenetic perturbations network modeling. During delay epoch, both...
In this paper, we study the dynamics of a quadratic integrate-and-fire neuron, spiking in gamma (30-100 Hz) range, coupled to delta/theta frequency (1-8 neural oscillator. Using analytical and semianalytical methods, were able derive characteristic times for system two distinct regimes (depending on parameter values): one regime where neuron is intrinsically oscillating absence theta input, second which directly gated by i.e., windows activity alternate with silence periods depending...
Abstract Decisions about future actions are held in memory until enacted, making them vulnerable to distractors. The neural mechanisms controlling decision robustness distractors remain unknown. We trained mice report optogenetic stimulation of somatosensory cortex, with a delay separating sensation and action. Distracting stimuli influenced behavior less when delivered later during – demonstrating temporal gating sensory information flow. Gating occurred even though distractor-evoked...
Neocortical spiking dynamics control aspects of behavior, yet how these emerge during motor learning remains elusive. Activity-dependent synaptic plasticity is likely a key mechanism, as it reconfigures network architectures that govern neural dynamics. Here, we examined the mouse premotor cortex acquires its well-characterized movement timing, specifically lick timing. To probe role plasticity, have genetically manipulated proteins essential for major forms Ca2+/calmodulin-dependent protein...
Summary Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice expression of the autism/intellectual disability gene, Syngap1 , cortical excitatory neurons is formation somatomotor networks promote SMI-mediated perception. Cortical was necessary and sufficient setting tactile sensitivity, sustaining object exploration, promoting learning. Mice with deficient...