A5087368229- Neural dynamics and brain function
- Long-Term Effects of COVID-19
- Memory and Neural Mechanisms
- Intensive Care Unit Cognitive Disorders
- Neural and Behavioral Psychology Studies
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- COVID-19 Clinical Research Studies
- Neuroscience and Neuropharmacology Research
- Neuroscience and Music Perception
- COVID-19 and Mental Health
- Genetics, Bioinformatics, and Biomedical Research
- Psychosomatic Disorders and Their Treatments
- Visual perception and processing mechanisms
- Evolutionary Algorithms and Applications
- Receptor Mechanisms and Signaling
- Delphi Technique in Research
- Face Recognition and Perception
- Autism Spectrum Disorder Research
- Experimental Learning in Engineering
- Infectious Encephalopathies and Encephalitis
- Memory Processes and Influences
- RNA regulation and disease
- Fibromyalgia and Chronic Fatigue Syndrome Research
Sainsbury Laboratory
2018-2025
University College London
2018-2025
Patient-Led Research Collaborative
2021-2024
Allen Institute
2024
University of Cambridge
2024
Harvard University
2024
The Francis Crick Institute
2023-2024
Imperial College London
2023-2024
Allen Institute for Neural Dynamics
2024
Sainsbury Wellcome Centre
2018-2024
A significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. Few systematic studies have investigated this population, particularly in outpatient settings. Hence, relatively little is about symptom makeup and severity, expected clinical course, impact on daily functioning, return to baseline health.We conducted an online survey people suspected confirmed COVID-19, distributed via support groups (e.g. Body Politic, COVID Support Group, Haul Fighters)...
Abstract Growing evidence shows that a significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. Few systematic studies exist which investigate this population, and hence, relatively little is about the range in symptom makeup severity, expected clinical course, impact on daily functioning, return to baseline health. In study, we analysed responses from 3,762 participants confirmed (diagnostic/antibody positive; 1,020) or suspected negative untested;...
A substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to long COVID but also known post-acute sequelae SARS-CoV-2 infection (PASC) or post-COVID-19 could become a significant global health burden.While the number studies investigating condition is increasing, there...
Abstract Background Long COVID occurs in those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whose symptoms persist or develop beyond the phase. We conducted a systematic review to determine prevalence of persistent symptoms, functional disability, pathological changes adults children at least 12 weeks postinfection. Methods searched key registers and databases from January 1, 2020 November 2, 2021, limited publications English studies 100 participants. Studies...
Abstract Delivering genes to and across the brain vasculature efficiently specifically species remains a critical challenge for addressing neurological diseases. We have evolved adeno-associated virus (AAV9) capsids into vectors that transduce endothelial cells following systemic administration in wild-type mice with diverse genetic backgrounds, rats. These AAVs also exhibit superior transduction of CNS non-human primates (marmosets rhesus macaques), ex vivo human slices, although tropism is...
Growing evidence shows that a significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. Few systematic studies exist which investigate this population, and hence, relatively little is about the range in symptom makeup severity, expected clinical course, impact on daily functioning, return to baseline health. In study, we analysed responses from 3762 participants confirmed (diagnostic/antibody positive, 1020) or suspected negative untested, 2742)...
Significance Many higher cognitive functions involve working memory (WM), the storage and manipulation of information across limited time intervals. Comparing WM capacity different species is a key step toward understanding underlying brain mechanisms. This study uncovers previously unknown sensory abilities in rats. They received two vibratory stimuli on their whiskers, separated by variable delay, had to compare vibration features. In analogous experiments, human subjects compared applied...
Rhythms with time scales of multiple cycles per second permeate the mammalian brain, yet neuroscientists are not certain their functional roles. One leading idea is that coherent oscillation between two brain regions facilitates exchange information them. In rats, hippocampus and vibrissal sensorimotor system both characterized by rhythmic in theta range, 5–12 Hz. Previous work has been divided as to whether rhythms independent or coherent. To resolve this question, we acquired three...
The central tendency bias, or contraction is a phenomenon where the judgment of magnitude items held in working memory appears to be biased toward average past observations. It assumed an optimal strategy by brain and commonly thought as expression brain’s ability learn statistical structure sensory input. On other hand, recency biases such serial dependence are also observed reflect content memory. Recent results from auditory delayed comparison task rats suggest that both may more related...
Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: simultaneous recording of hundreds neurons is now routinely carried out head-restrained animals. In contrast, neural unrestrained animals, as well and tracking over days, remains challenging, though it possible using chronic implants. A major challenge availability simple methods that can be implemented with limited or no prior experience probes, while achieving reliable, reusable, versatile...
To better understand how a stream of sensory data is transformed into percept, we examined neuronal activity in vibrissal cortex, vS1, together with motor vM1 (a frontal cortex target vS1), while rats compared the intensity two vibrations separated by an interstimulus delay. Vibrations were "noisy," constructed stringing over time sequence velocity values sampled from normal distribution; each vibration's mean speed was proportional to width distribution. Durations both stimulus 1 and 2...
Individual choices are not made in isolation but embedded a series of past experiences, decisions, and outcomes. The effects experiences on choices, often called sequential biases, ubiquitous perceptual value-based decision-making, their neural substrates unclear. We trained rats to choose between cued guaranteed probabilistic rewards task which outcomes each trial were independent. Behavioral variability reflected effects, including increased willingness take risks following risky wins,...
To realise a research project idea, an experimenter faces series of conflicting design and implementation considerations, regarding both its hardware software components. For instance, the ease implementation, in time expertise, should be balanced against future reconfigurability number ‘black box’ Other, often conflicting, considerations include level documentation reproducibility, resource availability as well access to online communities. alleviate this balancing act between opposing...