A5031109148- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Wildlife Ecology and Conservation
- Spatial Cognition and Navigation
- Ecology and Vegetation Dynamics Studies
- Sleep and Wakefulness Research
- Memory Processes and Influences
- Species Distribution and Climate Change
- Low-power high-performance VLSI design
- Child and Animal Learning Development
- Zebrafish Biomedical Research Applications
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- VLSI and Analog Circuit Testing
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Conservation, Biodiversity, and Resource Management
- African Botany and Ecology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Visual perception and processing mechanisms
- Image and Signal Denoising Methods
- Olfactory and Sensory Function Studies
- Posttraumatic Stress Disorder Research
- Numerical Methods and Algorithms
University College London
2016-2025
National Hospital for Neurology and Neurosurgery
2016-2025
Harvard University
2024
Allen Institute
2024
University of Cambridge
2004-2024
Wellcome Centre for Human Neuroimaging
2017-2024
Allen Institute for Neural Dynamics
2024
University College Hospital
2023
University of Copenhagen
2010-2022
World Conservation Monitoring Centre
2014-2022
The neural basis of navigation by humans was investigated with functional neuroimaging brain activity during in a familiar, yet complex virtual reality town. Activation the right hippocampus strongly associated knowing accurately where places were located and navigating between them. Getting to those quickly activation caudate nucleus. These two right-side structures function context inferior parietal bilateral medial regions that support egocentric movement through town, other left-side...
A connectionist model of human short-term memory is presented that extends the phonological loop (A. D. Baddeley, 1986) to encompass serial order and learning. Psychological neuropsychological data motivate separate layers lexical, timing, input output phonemic information. Connection weights between show Hebbian learning decay over short long time scales. At recall, timing signal rerun, information feeds back from input, lexical nodes compete be selected. The selected node then receives...
"Boundary vector cells" were predicted to exist by computational models of the environmental inputs underlying spatial firing patterns hippocampal place cells (O'Keefe and Burgess, 1996; Burgess et al., 2000; Hartley 2000). Here, we report existence fulfilling this description in recordings from subiculum freely moving rats. These may contribute information cell firing, complementing path integrative information. Their relationship other types, including medial entorhinal "border cells," is...
Memories are thought to be attractor states of neuronal representations, with the hippocampus a likely substrate for context-dependent episodic memories. However, such have not been directly observed. For example, hippocampal place cell representation location was previously found respond continuously changes in environmental shape alone. We report that exposure novel square and circular environments made different materials creates representations both shapes: Place cells abruptly...
Orienting in large-scale space depends on the interaction of environmental experience and preconfigured, possibly innate, constructs. Place, head-direction, grid cells hippocampal formation provide allocentric representations space. Here we show how these cognitive emerge develop as rat pups first begin to explore their environment. Directional, locational, rhythmic organization firing are present during initial exploration, including adultlike directional firing. The stability precision...
Abstract Place and grid cells in the hippocampal formation provide foundational representations of environmental location, potentially locations within conceptual spaces. Some accounts predict that sensory information self-motion are encoded complementary representations, while other models suggest both features combine to produce a single coherent representation. Here, we use virtual reality dissociate visual from physical motion inputs, recording place mice navigating open arenas. cell...
There is increasing evidence that areas of outstanding conservation importance may coincide with dense human settlement or impact. We tested the generality these findings using 1°-resolution data for sub-Saharan Africa. find population density positively correlated species richness birds, mammals, snakes, and amphibians. This association holds widespread, narrowly endemic, threatened looks set to persist in face foreseeable growth. Our results contradict earlier expectations low conflict...
Slowing rates of global biodiversity loss requires preventing species extinctions. Here we pinpoint centers imminent extinction, where highly threatened are confined to single sites. Within five globally assessed taxa (i.e., mammals, birds, selected reptiles, amphibians, and conifers), find 794 such species, three times the number recorded as having gone extinct since 1500. These occur in 595 sites, concentrated tropical forests, on islands, mountainous areas. Their taxonomic geographical...
How the memory systems centered on hippocampus and dorsal striatum interact to support behavior remains controversial. We used functional MRI while people learned locations of objects by collecting replacing them over multiple trials within a virtual environment comprising landmark, circular boundary, distant cues for orientation. The relative location landmark boundary was occasionally changed, with specific paired one or other cue, allowing dissociation learning performance either cue....