A5072210220- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- ATP Synthase and ATPases Research
- Evolutionary Algorithms and Applications
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Genetic Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Zebrafish Biomedical Research Applications
- Lipid Membrane Structure and Behavior
- Stress Responses and Cortisol
- Metabolism and Genetic Disorders
- Neuroendocrine regulation and behavior
- Neuroscience and Music Perception
- Neurotransmitter Receptor Influence on Behavior
- Phosphodiesterase function and regulation
- Neurological diseases and metabolism
- Complement system in diseases
- VLSI and FPGA Design Techniques
- Genetics and Neurodevelopmental Disorders
University College London
2010-2025
MathWorks (United States)
2024
Sainsbury Laboratory
2024
Emory University
2024
New York University
2012-2014
Rothamsted Research
2004
University of Cambridge
2004
Energy use, mainly to reverse ion movements in neurons, is a fundamental constraint on brain information processing. Trafficking of mitochondria locations neurons where there are large fluxes essential for powering neural function. Mitochondrial trafficking regulated by Ca2+ entry through ionotropic glutamate receptors, but the underlying mechanism unknown. We show that protein Miro1 links KIF5 motor proteins, allowing move along microtubules. This linkage inhibited micromolar levels binding...
The trafficking and function of cell surface proteins in eukaryotic cells may require association with detergent-resistant sphingolipid- sterol-rich membrane domains. aim this work was to obtain evidence for lipid domain phenomena plant membranes. A protocol prepare Triton X-100 membranes (DRMs) developed using Arabidopsis (Arabidopsis thaliana) callus comparative proteomics approach two-dimensional difference gel electrophoresis liquid chromatography-tandem mass spectrometry revealed that...
Correct mitochondrial distribution is critical for satisfying local energy demands and calcium buffering requirements supporting key cellular processes. The mitochondrially targeted proteins Miro1 Miro2 are important components of the transport machinery, but their specific roles in neuronal development, maintenance, survival remain poorly understood. Using mouse knockout strategies, we demonstrate that Miro1, as opposed to Miro2, primary regulator both axons dendrites. deletion leads...
Modification of the number GABA A receptors (GABA Rs) clustered at inhibitory synapses can regulate synapse strength with important implications for information processing and nervous system plasticity pathology. Currently, however, mechanisms that Rs remain poorly understood. By imaging superecliptic pHluorin tagged R subunits we show synaptic clusters are normally stable, but increased neuronal activity upon glutamate receptor (GluR) activation results in their rapid reversible dispersal....
Abstract The decision to either approach or avoid a potentially threatening environment is thought rely upon the coordinated activity of heterogeneous neural populations in hippocampus and prefrontal cortex (PFC). However, how this circuitry organized flexibly promote both avoidance at different times has remained elusive. Here, we show that hippocampal projection PFC composed two parallel circuits located superficial deep pyramidal layers CA1/subiculum border. These have unique upstream...
The ventral subiculum (vS) of the mouse hippocampus coordinates diverse behaviors through heterogeneous populations pyramidal neurons that project to multiple distinct downstream regions. Each these is proposed integrate a unique combination thousands local and long-range synaptic inputs, but extent which this occurs remains unknown. To address this, we employ monosynaptic rabies tracing study input-output relationship vS neurons. Analysis brain-wide inputs reveals quantitative input...
Hunger is an internal state that not only invigorates feeding but also acts as a contextual cue for higher-order control of anticipatory feeding-related behavior. The ventral hippocampus crucial differentiating optimal behavior across contexts, how contexts such hunger influence hippocampal circuitry unknown. In this study, we investigated the role during different states in mice. We found activity unique subpopulation neurons project to nucleus accumbens (vS-NAc neurons) increased when...
To realise a research project idea, an experimenter faces series of conflicting design and implementation considerations, regarding both its hardware software components. For instance, the ease implementation, in time expertise, should be balanced against future reconfigurability number ‘black box’ Other, often conflicting, considerations include level documentation reproducibility, resource availability as well access to online communities. alleviate this balancing act between opposing...
Abstract Turner syndrome (TS) is a chromosomal disorder of X-monosomy in females. A minority have impaired social responsiveness, poor discrimination facial emotions (especially fear), and abnormal amygdala–cortical connectivity. We tested the hypothesis that gaze fixation, especially with eye region faces, would be associated these features, similar pattern to seen subjects autism. Furthermore, since features tend more striking TS women whose X chromosome maternal origin, we also predicted...
ABSTRACT The ability to form and utilize subjective, latent contextual representations influence decision making is a crucial determinant of everyday life. hippocampus widely hypothesized bind together otherwise abstract combinations stimuli represent such contexts, allow their use support the process hidden state inference. Yet, direct evidence for this remains limited. Here we show that CA1 area ventral necessary mice perform inference during 2-armed bandit task. vCA1 neurons robustly...
The ability to use subjective, latent contextual representations influence decision-making is crucial for everyday life. hippocampus hypothesized bind together otherwise abstract combinations of stimuli represent such contexts, support the process hidden state inference. Yet evidence a role in inference remains limited. We found that ventral required mice perform during two-armed bandit task. Hippocampal neurons differentiate two contexts this strategy manner similar differentiation spatial...
Abstract Dopamine release in the nucleus accumbens has been hypothesized to signal reward prediction error, difference between observed and predicted reward, suggesting a biological implementation for reinforcement learning. Rigorous tests of this hypothesis require assumptions about how brain maps sensory signals predictions, yet mapping is still poorly understood. In particular, non-trivial when provide ambiguous information hidden state environment. Previous work using classical...
SUMMARY The decision to either approach or avoid a potentially threatening environment is thought rely upon complex connectivity between heterogenous neural populations in the ventral hippocampus and prefrontal cortex (PFC). However, how this circuitry can flexibly promote both avoidance at different times has remained elusive. Here, we show that projection PFC composed of two parallel circuits located superficial deep hippocampal pyramidal layers. These have unique upstream downstream...