A5017347022- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Prion Diseases and Protein Misfolding
- Amyotrophic Lateral Sclerosis Research
- Circadian rhythm and melatonin
- Fixed Point Theorems Analysis
- Neurogenetic and Muscular Disorders Research
- Zebrafish Biomedical Research Applications
University College London
2021-2023
King Saud University
2020
Abstract The decision to either approach or avoid a potentially threatening environment is thought rely upon the coordinated activity of heterogeneous neural populations in hippocampus and prefrontal cortex (PFC). However, how this circuitry organized flexibly promote both avoidance at different times has remained elusive. Here, we show that hippocampal projection PFC composed two parallel circuits located superficial deep pyramidal layers CA1/subiculum border. These have unique upstream...
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that characterized by cytoplasmic aggregates nuclear clearance of TAR DNA-binding protein 43 (TDP-43). Studies in Drosophila, zebrafish mouse demonstrate the neuronal dysfunction TDP-43 is causally related to disease formation. However, also observed glia muscle cells, which equally affected ALS FTLD; yet, it unclear whether glia- or muscle-specific contributes pathogenesis. Here,...
Hunger is an internal state that not only invigorates feeding but also acts as a contextual cue for higher-order control of anticipatory feeding-related behavior. The ventral hippocampus crucial differentiating optimal behavior across contexts, how contexts such hunger influence hippocampal circuitry unknown. In this study, we investigated the role during different states in mice. We found activity unique subpopulation neurons project to nucleus accumbens (vS-NAc neurons) increased when...
In this paper, we introduce some common fixed point theorems for two distinct self-mappings in the setting of metric spaces by using notion a simulation function introduced 2015. The contractivity conditions have not to be verified all pairs points space because it is endowed with an antecedent conditions. They are also rational type involved terms upper bound expressed, cases, as quotients.
Projections from the basal amygdala (BA) to ventral hippocampus (vH) are proposed provide information about rewarding or threatening nature of learned associations support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via differential activity multiple, parallel populations pyramidal neurons in vH that project distinct downstream targets, but BA input how it connects with these is unclear. Using channelrhodopsin-2-assisted circuit mapping mice, we show consists...
ABSTRACT Projections from the basal amygdala (BA) to ventral hippocampus (vH) are proposed provide information about rewarding or threatening nature of learned associations support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via differential activity multiple, parallel populations pyramidal neurons in vH that project distinct downstream targets, but BA input how it connects with these is unclear. Using channelrhodopsin-2-assisted circuit mapping mice, we show...
ABSTRACT Hunger is an internal state that not only invigorates feeding, but also acts as a contextual cue for the higher-order control of anticipatory feeding-related behaviour. The ventral hippocampus brain region crucial differentiating optimal behaviour across different contexts, how context such hunger influence hippocampal circuits to define known. Pyramidal neurons in hippocampus, including CA1/subiculum border (vS) express receptor peripheral hormone ghrelin, and ghrelin known cross...