A5080249780- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Cell Image Analysis Techniques
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- ATP Synthase and ATPases Research
- Vestibular and auditory disorders
- Retinal Development and Disorders
- Sleep and Wakefulness Research
University College London
2011-2020
Medical Research Council
2010
University of Oxford
2010
Yale University
2009
Correct mitochondrial distribution is critical for satisfying local energy demands and calcium buffering requirements supporting key cellular processes. The mitochondrially targeted proteins Miro1 Miro2 are important components of the transport machinery, but their specific roles in neuronal development, maintenance, survival remain poorly understood. Using mouse knockout strategies, we demonstrate that Miro1, as opposed to Miro2, primary regulator both axons dendrites. deletion leads...
Activity in neocortex is often characterized by synchronized oscillations of neurons and networks, resulting the generation a local field potential (LFP) electroencephalogram. Do neuronal networks cerebellum also generate are they under influence those neocortex? Here we show that, absence any overt external stimulus, cerebellar cortex generates slow oscillation that correlated with neocortex. Disruption neocortical abolishes oscillation, whereas blocking activity has no effect on We provide...
Two-photon microscopy is widely used to study brain function, but conventional microscopes are too slow capture the timing of neuronal signalling and imaging restricted one plane. Recent development acousto-optic-deflector-based random access functional has improved temporal resolution, utility these technologies for mapping 3D synaptic activity patterns their performance at excitation wavelengths required image genetically encoded indicators have not been investigated.Here, we a compact...
The cerebellum gathers information from the neocortex via cortico-ponto-cerebellar pathway, and forms sensorimotor associations for predicting movements their sensory consequences. However, little is known about functional properties of this major input to cerebellar cortex. Recordings individual mossy fibre axons (MFAs) have shown that they convey motor information, but nothing population code. Here, we report activity pontine MFAs heterogeneous, high-dimensional different subpopulations...