A5082636031- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Zebrafish Biomedical Research Applications
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Primate Behavior and Ecology
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Physiological and biochemical adaptations
- Neuroscience of respiration and sleep
- Embodied and Extended Cognition
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- CCD and CMOS Imaging Sensors
Sainsbury Wellcome Centre
2019-2024
University College London
2018-2024
Allen Institute
2024
Allen Institute for Neural Dynamics
2024
Harvard University
2024
University of Cambridge
2024
Cold Spring Harbor Laboratory
2015-2021
Wellcome Centre for Human Neuroimaging
2018
Karolinska Institutet
2011-2014
The group of nuclei within the basal ganglia forebrain is central to control movement. We present data showing that structure and function have been conserved throughout vertebrate evolution over some 560 million years. interaction between different as well cellular synaptic properties transmitters. consider role circuitry for basic patterns motor behaviour controlled via brainstem circuits. output consists tonically active GABAergic neurones, which target centres responsible behaviour, such...
Abstract The basal ganglia, including the striatum, globus pallidus interna and externa (GPe), subthalamic nucleus (STN), substantia nigra pars compacta, are conserved throughout vertebrate phylogeny have been suggested to form a common mechanism for action selection. In mammals, this circuitry is further elaborated by presence of dual‐output nucleus, reticulata (SNr), modulatory input from cholinergic pedunculopontine (PPN). We sought determine whether these additional components mammalian...
The medial (MHb) and lateral (LHb) habenulae are a small group of nuclei that regulate the activity monoaminergic neurons. Disruptions to these lead deficits in range cognitive motor functions from sleep decision making. Interestingly, habenular present all vertebrates, suggesting they provide common neural mechanism influence diverse functions. To unravel conserved habenula circuitry approach an understanding their basic function, we investigated organization lamprey, one phylogenetically...
The basal ganglia are critical for selecting actions and evaluating their outcome. Although the circuitry selection is well understood, how these nuclei evaluate outcome of unknown. Here, we show in lamprey that a separate evaluation circuit, which regulates habenula-projecting globus pallidus (GPh) neurons, exists within ganglia. GPh neurons glutamatergic can drive activity lateral habenula, which, turn, provides an indirect inhibitory influence on midbrain dopamine neurons. We receive...
Abstract Animals’ choice behavior is characterized by two main tendencies: taking actions that led to rewards and repeating past actions. Theory suggests these strategies may be reinforced different types of dopaminergic teaching signals: reward prediction error (RPE) reinforce value-based associations movement-based action errors value-free repetitive associations. Here we use an auditory-discrimination task in mice show movement-related dopamine activity the tail striatum encodes...
The functions of the basal ganglia are critically dependent on dopamine. In mammals, dopamine differentially modulates excitability direct and indirect striatal projection neurons, these populations selectively express D 1 2 receptors, respectively. Although detailed organization is conserved throughout vertebrate phylum, it was unknown whether differential modulation pathways present in non-mammalian species. We aim here to determine receptor expression opposing dopaminergic one...
The dopaminergic system influences motor behavior, signals reward and novelty, is an essential component of the basal ganglia in all vertebrates including lamprey, one phylogenetically oldest vertebrates. intrinsic organization function lamprey highly conserved. For instance, direct indirect pathways are modulated through dopamine D1 D2 receptors mammals. nucleus tuberculum posterior, a homologue substantia nigra pars compacta (SNc)/ventral tegmental area (VTA) present but only scarce data...
Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: simultaneous recording of hundreds neurons is now routinely carried out head-restrained animals. In contrast, neural unrestrained animals, as well and tracking over days, remains challenging, though it possible using chronic implants. A major challenge availability simple methods that can be implemented with limited or no prior experience probes, while achieving reliable, reusable, versatile...
The ventral pallidum (VP) lies at the intersection of basal ganglia and forebrain circuitry, possessing attributes both major subcortical systems. Basal cholinergic neurons are rapidly recruited by reinforcement feedback project to cortical targets; in contrast, striatal cells local interneurons exhibiting classical 'pause-burst' responses rewards. However, VP (VPCNs) less characterized, it is unclear whether type mix VP. Therefore, we performed anterograde mono-transsynaptic retrograde...
All basal ganglia subnuclei have recently been identified in lampreys, the phylogenetically oldest group of vertebrates. Furthermore, interconnectivity these nuclei is similar to mammals and tyrosine hydroxylase-positive (dopaminergic) fibers detected within input layer, striatum. Striatal processing critically dependent on interplay with dopamine system, we explore here whether D2 receptors are expressed lamprey striatum their potential role. We a cDNA encoding receptor from brain deduced...
Key points Recent studies have shown that the striatum and basal ganglia are to a remarkable degree conserved throughout vertebrate phylum. As basic organization of neural machinery for action selection is present in lamprey, it essential understand how activated. In this study we characterize pharmacology synaptic dynamics from lateral pallium (LPal; cortex) thalamus (Th), main excitatory input striatum. We show that, as mammals, LPal Th provide glutamatergic excitation striatum, but with...
Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: simultaneous recording of hundreds neurons is now routinely carried out head-restrained animals. In contrast, neural unrestrained animals, as well and tracking over days, remains challenging, though it possible using chronic implants. A major challenge availability simple methods that can be implemented with limited or no prior experience probes, while achieving reliable, reusable, versatile...
ABSTRACT The ventral pallidum (VP) is critical for invigorating reward seeking and also involved in punishment avoidance, but how it contributes to such opposing behavioural actions remains unclear. Here we show that GABAergic glutamatergic VP neurons selectively control behaviour motivational contexts. In vivo recording combined with optogenetics mice revealed these two populations oppositely encode positive negative value, are differentially modulated by animal’s internal state determine...
Animals rely on internal motivational states to make decisions. The role of salience in decision making is early stages mathematical understanding. Here, we propose a reinforcement learning framework that relies neural networks learn optimal ongoing behavior for dynamically changing motivation values. First, show implementing Q-learning with can navigate environment dynamic rewards without adjustments synaptic strengths when the needs an agent shift. In this setting, our may display elements...
Abstract Sleep is critical for consolidating all forms of memory 1-3 , from episodic experience to the development motor skills 4-6 . A core feature consolidation process offline replay neuronal firing patterns that occur during 7,8 This thought originate in hippocampus and trigger reactivation ensembles cortical subcortical neurons 1,3,9-18 However, non-declarative memories do not require learning or sleep-dependent 19-26 meaning what drives their unknown. Here we show, using an...
Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: simultaneous recording of hundreds neurons is now routinely carried out head-restrained animals. In contrast, neural unrestrained animals, as well and tracking over days, remains challenging, though it possible using chronic implants. A major challenge availability simple methods that can be implemented with limited or no prior experience probes, while achieving reliable, reusable, versatile...
The ventral pallidum (VP) is critical for invigorating reward seeking and also involved in punishment avoidance, but how it contributes to such opposing behavioural actions remains unclear. Here we show that GABAergic glutamatergic VP neurons selectively control behaviour motivational contexts. In vivo recording combined with optogenetics mice revealed these two populations oppositely encode positive negative value, are differentially modulated by animal’s internal state determine the...
The globus pallidus is a major output station for the basal ganglia, subcortical region of brain that heavilyimplicated in action selection and decision making. A subpopulation neurons internal segment (GPi) projects tothe laternal habenula (LHb), often associated with limbic system known to encode negative motivational value.Dysfunction these structures have been implicated neurological diseases, such as depression schizophrenia,which are ultimately disruptions ability evaluate...