A5102789786- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Hormonal Regulation and Hypertension
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Photoreceptor and optogenetics research
- Birth, Development, and Health
Tata Institute of Fundamental Research
2017-2024
Sainsbury Wellcome Centre
2022
University College London
2022
Abstract Animals’ choice behavior is characterized by two main tendencies: taking actions that led to rewards and repeating past actions. Theory suggests these strategies may be reinforced different types of dopaminergic teaching signals: reward prediction error (RPE) reinforce value-based associations movement-based action errors value-free repetitive associations. Here we use an auditory-discrimination task in mice show movement-related dopamine activity the tail striatum encodes...
Abstract Designer receptors exclusively activated by designer drugs (DREADD)-based chemogenetic tools are extensively used to manipulate neuronal activity in a cell type-specific manner. Whole-cell patch-clamp recordings indicate membrane depolarization, coupled with increased firing rate, following administration of the DREADD ligand, clozapine-N-oxide (CNO) activate Gq-coupled DREADD, hM3Dq. Although hM3Dq has been enhance order diverse behaviors, often within 30 min 1 h after CNO...
The early stress of Maternal Separation (MS) contributes to the establishment adult psychopathology. serotonergic (5-HT) system is implicated during this temporal window in mediating development mood-related behaviors. MS reported evoke altered 5-HT2A receptor function adulthood. However, ontogeny responsivity following remains unknown. Here, we examined agonist, DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) (2mg/kg) evoked responses, namely stereotypical head-twitch behaviors control...
Early adversity is a risk factor for the development of adult psychopathology. Common across multiple rodent models early increased signaling via forebrain Gq-coupled neurotransmitter receptors. We addressed whether enhanced Gq-mediated in excitatory neurons during postnatal life can evoke persistent mood-related behavioral changes. Excitatory hM3Dq DREADD-mediated chemogenetic activation (P2–14), but not juvenile or windows, anxiety-, despair-, and schizophrenia-like behavior adulthood....
Anxiety disorders are amongst the most prevalent mental health disorders. Several lines of evidence have implicated cortical regions such as medial prefrontal cortex, orbitofrontal and insular cortex along with hippocampus in top-down modulation anxiety-like behaviour animal models. Both rodent models anxiety, well treatment anxiolytic drugs, result concomitant activation multiple forebrain regions. Here, we sought to examine effects chemogenetic or inhibition principal neurons on anxiety...
Animal models of early adversity or neurodevelopmental disorders are associated with altered parvalbumin (PV)-positive inhibitory interneuron number and function, correlated a dysregulated excitation-inhibition (E/I) balance that is implicated in the pathophysiology neuropsychiatric disorders. We sought to address whether altering neuronal activity PV-positive interneurons during postnatal developmental window influences emergence anxio-depressive behaviors adulthood, which known be...
Adult hippocampal neurogenesis is a lifelong process that involves the integration of newborn neurons into network, and plays role in cognitive function modulation mood-related behavior. Here, we sought to address impact chemogenetic activation adult progenitors on distinct stages progenitor development, including quiescent stem cell activation, turnover, differentiation morphological maturation. We find hM3Dq-DREADD-mediated nestin-positive recruits cells, enhances proliferation, increases...
Abstract Designer Receptors Exclusively Activated by Drugs (DREADD)-based chemogenetic tools are extensively used to manipulate neuronal activity in a cell-type specific manner. Whole-cell patch-clamp recordings indicate membrane depolarization, coupled with increased firing rate, following administration of the DREADD ligand, Clozapine-N-Oxide (CNO) activate Gq-coupled DREADD, hM3Dq. Although hM3Dq has been enhance order diverse behaviors, often within thirty minutes an hour post-CNO...
Abstract Early adversity is a key risk factor for the development of adult psychopathology, including anxiety, depression and schizophrenia. Rodent models early program persistent behavioral, molecular, metabolic, neurophysiological changes. Perturbed signaling via forebrain Gq-coupled neurotransmitter receptors common feature across multiple adversity. We addressed whether enhanced Gq-mediated in excitatory neurons during postnatal life can evoke long-lasting mood-related behavioral...
Abstract Adult hippocampal neurogenesis is a lifelong process that involves the integration of newborn neurons into network, and plays role in cognitive function modulation mood-related behavior. Here, we sought to address impact chemogenetic activation adult progenitors on distinct stages progenitor development, including quiescent stem cell activation, turnover, differentiation morphological maturation. We find hM3Dq-DREADD-mediated nestin-positive recruits cells, enhances proliferation,...