A5043363197- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Data Visualization and Analytics
- CCD and CMOS Imaging Sensors
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Retinal Development and Disorders
- Cell Image Analysis Techniques
- Cognitive Science and Education Research
- Viral Infectious Diseases and Gene Expression in Insects
- Bacterial Genetics and Biotechnology
- Gene Regulatory Network Analysis
Sainsbury Laboratory
2024
University College London
2022-2024
Allen Institute for Neural Dynamics
2024
Harvard University
2024
Allen Institute
2024
University of Cambridge
2024
Columbia University
2019-2022
Brain (Germany)
2021
University of Southern Denmark
2014-2020
Odense University Hospital
2020
Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: simultaneous recording of hundreds neurons is now routinely carried out head-restrained animals. In contrast, neural unrestrained animals, as well and tracking over days, remains challenging, though it possible using chronic implants. A major challenge availability simple methods that can be implemented with limited or no prior experience probes, while achieving reliable, reusable, versatile...
Animals are intrinsically motivated to obtain information independently of instrumental incentives. This motivation depends on two factors: a desire resolve uncertainty by gathering accurate and positively-valenced observations, which predict favorable rather than unfavorable outcomes. To understand the neural mechanisms, we recorded parietal cortical activity implicated in prioritizing stimuli for spatial attention gaze, task monkeys were free (but not trained) about probabilistic...
This is the protocol associated with Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components. In main report, we describe development, deployment, and evaluation of Repix, a implantation system that permits repeated re-use probes characterized this for variety use cases. appropriate in -Both unrestrained restrained animals performing wide behaviors as decision-making, social behaviors, foraging, sleep -Mice rats -Neuropixels 1.0 or 2.0 (as well Neuronexus...
Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: simultaneous recording of hundreds neurons is now routinely carried out head-restrained animals. In contrast, neural unrestrained animals, as well and tracking over days, remains challenging, though it possible using chronic implants. A major challenge availability simple methods that can be implemented with limited or no prior experience probes, while achieving reliable, reusable, versatile...
Neuropixels probes represent the state-of-the-art for high-yield electrophysiology in neuroscience: simultaneous recording of hundreds neurons is now routinely carried out head-restrained animals. In contrast, neural unrestrained animals, as well and tracking over days, remains challenging, though it possible using chronic implants. A major challenge availability simple methods that can be implemented with limited or no prior experience probes, while achieving reliable, reusable, versatile...
We argue that the type of meta-learning proposed by Binz et al. generates models with low interpretability and falsifiability have limited usefulness for neuroscience research. An alternative approach to based on hyperparameter optimization obviates these concerns can generate empirically testable hypotheses biological computations.
The lac promoter is one of the most commonly used promoters for expression control recombinant genes in E. coli. In absence galactosides, repressed by its repressor protein LacI. Since regulated a repressor, overexpression LacI necessary regulation when introduced on high-copy plasmid. For that purpose, modified variant LacI, LVA-tagged was submitted to Registry Standard Biological Parts and has been more than 500 constructs since then. We have found, however, natural superior as controller...
Abstract Gathering information is crucial for maximizing fitness, but requires diverting resources from searching directly primary rewards to actively exploring the environment. Optimal decision-making thus maximizes while reducing effort costs, little known about neural implementation of these tradeoffs. We present a Reinforcement Meta-Learning (RML) computational mechanism that solves trade-offs between value and costs gathering information. implement RML in biologically plausible...
Abstract Animals are intrinsically motivated to resolve uncertainty and predict future events. This motivation is encoded in cortical subcortical structures, but a key open question how it generates concrete policies for attending informative stimuli. We examined this using neural recordings the monkey lateral intraparietal area (LIP), visual implicated attention gaze, during non-instrumental information demand. show that was resolved by cue enhanced visuo-spatial responses of LIP cells...