A5103230007- Cardiac Arrest and Resuscitation
- Pain Management and Treatment
- Transcranial Magnetic Stimulation Studies
- Cardiac Ischemia and Reperfusion
- Mechanical Circulatory Support Devices
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Neurological and metabolic disorders
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Non-Invasive Vital Sign Monitoring
- Acute Ischemic Stroke Management
- Cardiac Health and Mental Health
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2018-2024
Odense University Hospital
2002-2024
University of Freiburg
2017-2023
University Medical Center Freiburg
2022-2023
University Hospital in Halle
2022
The University of Texas at Austin
2021-2022
University of Tübingen
2012
Asan Medical Center
2008
Hospital de Sant Pau
2008
Aarhus University Hospital
2008
Aim: The availability of long-term (>2 years) safety outcomes spinal cord stimulation (SCS) remains limited. We evaluated in a global SCS registry for chronic pain. Methods: Participants were prospectively enrolled globally at 79 implanting centers and followed out to 3 years after device implantation. Results: Of 1881 participants enrolled, 1289 received permanent implant (1776 completed trial). annualized rate explant was 3.5% (all causes), 1.1% due inadequate pain relief. Total incidence...
Cardiopulmonary resuscitation (CPR) is associated with a high mortality rate. Furthermore, the few survivors often have severe, persistent cerebral dysfunction. A potential cause for this unsatisfactory outcome after CPR combination of cardiac arrest (ischemia) and inability to restore adequate hemodynamics during conventional (reperfusion), resulting in ischemia/reperfusion injury whole body. Therefore we developed concept counteracting process CPR.We present data from patient, whom novel...
Patients implanted with a cardioverter defibrillator (ICD) who are suffering from refractory angina pectoris could benefit spinal cord stimulation (SCS) due to the well-documented pain relieving effect. However, combined treatment remains controversial. The aim of study is report successful long-term SCS in five patients defibrillators. treatments ICD and thoracic epidural electrical were used pectoris. During procedure implantation, testing maximal tolerable level was carried out exclude...
Abstract The reperfusion period after extracorporeal cardiopulmonary resuscitation has been recognized as a key player in improving the outcome cardiac arrest (CA). Our aim was to evaluate effects of high mean arterial pressure (MAP) and pulsatile flow during controlled automated whole body. Following 20 min normothermic CA, MAP, blood (pulsatile group, n = 10) or low MAP nonpulsatile (nonpulsatile 6) body commenced through femoral vessels German landrace pigs for 60 min. Afterwards, animals...
Only a small number of patients survive an out-of-hospital cardiac arrest (CA) and can be discharged from hospital alive with large percentage these retaining neurological impairments. In recent years, extracorporeal cardiopulmonary resuscitation (ECPR) has emerged as beneficial strategy to optimize treatment. However, ECPR is still associated various complications. To reduce problems, profound understanding the underlying mechanisms required. This study aims investigate effects CA,...
Objective The extracorporeal life support system (ECLS) is a lifesaving option for patients in pulmonary and/or cardiac failure. We reviewed our data on local complications the leg and groin during after ECLS explantation. Methods Patients were included when an was cannulated successfully weaned explanted. Data collected retrospectively from January 2013 to 2016. Results In this study, 90 included; 39 (43%) implanted with surgical cut down 51 (57%) percutaneously. Most needed following...
Survival and neurological outcomes after out-of-hospital cardiac arrest (OHCA) remain low. The further development of prehospital extracorporeal resuscitation (ECPR) towards Controlled Automated Reperfusion the Whole Body (CARL) has potential to improve survival outcome in these patients. In CARL therapy, pulsatile, high blood-flow reperfusion is performed combined with several modified parameters adjusted defibrillation strategies. We aimed investigate whether high-flow feasible refractory...
Regarding the overall inadequate results after cardiopulmonary resuscitation, development of new treatment concepts is urgently needed. Controlled Automated Reperfusion whoLe body (CARL) represents a therapy bundle to control conditions reperfusion and composition reperfusate cardiac arrest (CA). The aim this study was investigate plasma expander's role in CARL priming solution examine its mechanism action.Viscosity, osmolality, colloid osmotic pressure (COP), pH calcium binding different...
Background: Controlled reperfusion by monitoring blood pressure, flow and specific parameters during extracorporeal after cardiac arrest has the potential to limit ischemia-reperfusion injury. The intracellular calcium overload as part of injury provides possibility be counteracted an early suppression serum with aim improving survival neurological outcome.
ObjectivesChronic pain poses a significant health challenge worldwide and is associated with both disability reduced quality of life. Sleep disturbances are reported in 67% to 88% patients chronic pain.Pain sleep affect each other reciprocally; we aimed study this bidirectional relationship treated spinal cord stimulation (SCS) for pain. Specifically, investigated whether improves after treatment SCS improvement may be mediated by reduction.Materials MethodsAn observational cohort was...
Controlled reperfusion by monitoring the blood pressure, flow, and specific parameters during extracorporeal after cardiac arrest has potential to limit ischemia–reperfusion injury. The intracellular calcium overload as part of injury provides possibility for be counteracted early suppression serum with aim improving survival neurological outcome. We investigated effects prolonged via sodium citrate resuscitation using CARL protocol (CARL—controlled automated whole body) compared a...
Introduction: Based on extracorporeal circulation, targeted reperfusion strategies have been developed to improve survival and neurologic recovery in refractory cardiac arrest: Controlled Automated Reperfusion of the whoLe Body (CARL). Furthermore, animal human cadaver studies shown beneficial effects cerebral pressure due head elevation during conventional cardiopulmonary resuscitation. Our aim was evaluate impact survival, histopathologic outcome addition CARL an model. Methods: After 20...
In diesem Beitrag werden Ergebnisse eines Berechnungsverfahrens zur Bewertung relativen Infektionsrisikos vorgestellt, mit dem eine (beliebige) Raumsituation einer Referenzsituation verglichen kann. Die beschreibt einen Klassenraum maschineller Belüftung, ausgelegt nach heutigen Stand der Technik. Dabei wird vorausgesetzt, dass keine absolute Sicherheit vorliegt, jedoch nur sehr geringe Infektionswahrscheinlichkeit angenommen wird. Durch die Wahl Raum- und Lüftungsparameter sichergestellt,...