A5066464863- Musculoskeletal pain and rehabilitation
- Cannabis and Cannabinoid Research
- Pain Management and Treatment
- Opioid Use Disorder Treatment
- Migraine and Headache Studies
- Pain Mechanisms and Treatments
- Religion, Spirituality, and Psychology
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Trigeminal Neuralgia and Treatments
- Laser Applications in Dentistry and Medicine
- Spine and Intervertebral Disc Pathology
- Olfactory and Sensory Function Studies
- Substance Abuse Treatment and Outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Sympathectomy and Hyperhidrosis Treatments
- Photoacoustic and Ultrasonic Imaging
- Ergonomics and Musculoskeletal Disorders
- Sleep and related disorders
- Long-Term Effects of COVID-19
- Restless Legs Syndrome Research
- Transcranial Magnetic Stimulation Studies
- Intramuscular injections and effects
- Pain Management and Placebo Effect
Sheba Medical Center
2014-2025
Tel Aviv University
2019
Hadassah Medical Center
2004-2005
Massachusetts General Hospital
2003
Beth Israel Deaconess Medical Center
2000
Recent animal studies on the mechanism of migraine show that intracranial pain is accompanied by increased periorbital skin sensitivity. These findings suggest pathophysiology involves not only irritation meningeal perivascular fibers but also a transient increase in responsiveness (ie, sensitization) central neurons process information arising from structures and skin. The purpose this study was to determine whether sensitivity observed develops humans during attacks. Repeated measurements...
Although studied in a few randomized controlled trials, the efficacy of medical cannabis (MC) for chronic pain remains controversial. Using an alternative approach, this multicentre, questionnaire-based prospective cohort was aimed to assess long-term effects MC on various aetiologies and identify predictors treatment success.Patients with pain, licensed use Israel, reported weekly average intensity (primary outcome) related symptoms before at 1, 3, 6, 9 12 months following initiation. A...
Background.—Neurologic signs of increased parasympathetic outflow to the head often accompany migraine attacks. Because cranial cavity induces vasodilation cerebral and meningeal blood vessels, it can enhance plasma protein extravasation release proinflammatory mediators that activate perivascular nociceptors. We recently showed activation intracranial nociceptors peripheral central sensitization along trigeminovascular pathway proposed these sensitizations mediate hypersensitivity cutaneous...
Aim: The availability of long-term (>2 years) safety outcomes spinal cord stimulation (SCS) remains limited. We evaluated in a global SCS registry for chronic pain. Methods: Participants were prospectively enrolled globally at 79 implanting centers and followed out to 3 years after device implantation. Results: Of 1881 participants enrolled, 1289 received permanent implant (1776 completed trial). annualized rate explant was 3.5% (all causes), 1.1% due inadequate pain relief. Total incidence...
To assess prevalence rates and correlates of problematic use prescription opioids medicinal cannabis (MC) among patients receiving treatment for chronic pain.Cross-sectional study.Two leading pain clinics in Israel.Our sample included 888 individuals pain, whom 99.4% received with or MC.Problematic MC was assessed using DSM-IV criteria, Portenoy’s Criteria (PC), the Current Opioid Misuse Measure (COMM) questionnaire. Additional sociodemographic clinical were also assessed.Among treated...
To investigate the rates of hospitalization, opioid prescription, supportive care, hospice referral, and 30-day all-cause mortality in patients with metastatic cancer abdominal pain admitted to either Emergency Department (ED) or Oncology ED. We conducted a retrospective cohort study ED at tertiary medical center between June 2020 May 2022. The MDClone ADAMS Platform, healthcare data analytics environment, was used for collection. Inverse probability weighting (IPW) based on propensity...
The scientific study of the role cannabis in pain medicine still lags far behind growing use driven by public approval. Accumulated clinical experience is therefore an important source knowledge. However, no to date has targeted physicians who actually their daily practice.Registered, active, board-certified specialists Israel (n=79) were asked complete a Web-based survey. survey was developed using Qualtrics Online Survey Software. Questions formulated as multiple-choice questions, and...
A phantom experiment, two thermocouple experiments, three in vivo pig and a simulated treatment on healthy human volunteer were conducted to test the feasibility, safety, efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) for treating facet joint pain. The goal current study was develop novel method accurate safe noninvasive ablation using MRgFUS. Facet joints are common source chronic back Direct interventions include medial branch nerve intra-articular injections, which...
Recent animal studies on the mechanism of migraine show that intracranial pain is accompanied by increased periorbital skin sensitivity. These findings suggest pathophysiology involves not only irritation meningeal perivascular fibers but also a transient increase in responsiveness (ie, sensitization) central neurons process information arising from structures and skin. The purpose this study was to determine whether sensitivity observed develops humans during attacks. Repeated measurements...
Background Fibromyalgia syndrome (FMS), the prototypical central pain augmentation syndrome, is characterized by widespread and tenderness. Although patients referred to tertiary care clinics are recognized as suffering from chronic pain, they generally considered have attributable discrete peripheral, nociceptive, or neuropathic etiology. The purpose of current study was assess prevalence FMS among consecutive a clinic evaluate contribution clinical impact upon such patients. Methods...
Electrotherapy is part of a physician's toolbox for treating various musculoskeletal conditions, including radicular pain, but the preferred modality yet unclear.To compare short-term efficacy three electrotherapeutic modalities in relieving lumbar disc herniation (LDH)-induced pain.Fourteen patients with LDH-induced pain attended single session electrotherapy, which included four 10-min consecutive treatments: transcutaneous electrical nerve stimulation (TENS), interferential (IF)...
Ample evidence suggests that individuals with borderline personality disorder (BPD) exhibit hyposensitivity to pain. Since the underlying mechanism of pain is unknown, we tested here for first time whether this specific or exists also innocuous sensation, and it associated enhanced descending modulation capabilities.Participants were 55 women; 22 patients BPD 33 matched healthy controls. Testing included measurement warmth sensation threshold (WST), heat-pain (HPT), adaptation, conditioned...
Gaps between physician and patient perceptions may lead to misunderstandings mismanage of treatment. There are sparse data about the differences in opinions toward medical cannabis (MC) patients health professionals. The aim this study was examine attitudes MC, its perceived efficacy, side effects risk dependency, among patients, nurses physicians. A cross-sectional samples 430 65 physicians two large centers Israel. Questionnaires were administered on attitudes, side-effects risks...
Electrotherapy provides a wide range of treatment alternatives for musculoskeletal pathologies. However, the electrical stimulation to exert significant therapeutic effect, induced current must often penetrate deep inside target tissue.The objective was systematically compare penetration efficiency 3 electrotherapeutic modalities: transcutaneous nerve (TENS), interferential (IF) stimulation, and combined therapy with pulsed ultrasound IF (CTPI).This comparative, experimental laboratory...
Objective.—To determine whether delayed infusion of COX1/COX2 inhibitors (ketorolac, indomethacin) will stop migraine in allodynic patients, and suppress ongoing sensitization central trigeminovascular neurons the rat. Background.—The majority migraineurs seeking secondary or tertiary medical care develop cutaneous allodynia during course migraine, a sensory abnormality mediated by spinal trigeminal nucleus. Triptan therapy can render pain free within narrow window time (20 to 120 minutes)...
Objective: To evaluate patterns of opioid handling as well their associated variables.
 Design: A transversal study.
 Setting: Institutional care.
 Participants: One hundred cancer pain patients aged 18 and above at diagnosis.
 Interventions: Open dichotomous questions related to a depression-anxiety scale.
 Main outcome measure(s): The percentage who properly handled opioids.
 Results: Of those surveyed, 42.1 percent reported receiving storage instructions, 73...
The novel coronavirus pandemic (COVID-19), which began in late 2019, has affected all aspects of our everyday life. medical ecosystem changed profoundly, at times stretching its capacity, to provide proper healthcare those need. Recent investigations have focused on the impact virus emergency departments and intensive care units. However, outpatient also been fundamentally transformed since pandemic. There is no consensus best way manage patients with severe pain during COVID-19 Multiple...