A5073155984- Emergency and Acute Care Studies
- Musculoskeletal pain and rehabilitation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Healthcare cost, quality, practices
- 3D Printing in Biomedical Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Artificial Intelligence in Healthcare and Education
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Technology
- COVID-19 and healthcare impacts
- Ethics in Clinical Research
- Clinical practice guidelines implementation
- Healthcare Policy and Management
- Long-Term Effects of COVID-19
- Chemotherapy-related skin toxicity
- Spine and Intervertebral Disc Pathology
- Machine Learning in Healthcare
- Additive Manufacturing and 3D Printing Technologies
- Radiomics and Machine Learning in Medical Imaging
- Methemoglobinemia and Tumor Lysis Syndrome
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Medical and Health Sciences Research
- Delphi Technique in Research
- Effects of Radiation Exposure
University Medical Center Freiburg
2017-2025
University of Freiburg
2017-2025
University Medical Center
2024
Abstract In tissue engineering applications, vascularization can be accomplished by coimplantation of forming cells and endothelial (ECs), whereby the latter are able to form functional blood vessels. The use three‐dimensional (3D) bioprinting technologies has potential improve classical approach because these will allow generation scaffolds with high spatial control cell allocation. This study focuses on a side comparison popular commercially available hydrogels (Matrigel, fibrin, collagen,...
We present (1) a fast and automated method for large scale production of HUVEC spheroids based on the hanging drop (2) novel well-controlled lateral deposition single by drop-on-demand printing. Large spheroid is achieved via printing 1536 droplets cell suspension having volume 1 μl each within 3 min at pitch 2.3 mm an array 48 × 32 onto flat substrate. Printing efficiencies between 97.9% 100% plating 87.3% were achieved. Harvested (consisting approx. 250 HUVECs each) appear uniform in size...
Background The recommended first-line treatment for unspecific and degenerative back pain consists of movement exercises patient education. Objective Using a pragmatic, randomized controlled trial, we evaluated the effectiveness digital home exercise program on self-reported intensity compared with standard care physiotherapy. Methods Participant recruitment was based newspaper advertisements consecutive on-site assessment eligibility enrollment. Participants aged ≥18 years were randomly...
Abstract Background Emergency department (ED) routine data offer a unique opportunity for syndromic surveillance of communicable and noncommunicable diseases (NCDs). In 2020, the Robert Koch Institute established system using ED from AKTIN registry. The provides daily insights into utilization infectious diseases. Adding NCD indicators to is great public health importance, especially during acute events, where timely monitoring enables targeted responses communication. Objective This study...
Abstract The last two decades saw the establishment of three-dimensional (3D) cell cultures as an acknowledged tool to investigate behaviour in a tissue-like environment. Cells growing spheroids differentiate and develop different characteristics comparison their two-dimensionally grown counterparts are hence seen exhibit more vivo-like phenotype. However, generating, treating analysing high quantities remains labour intensive therefore limits its applicability drugs compound research. Here...
Abstract Background Healthcare systems around the world experience increasing pressure to control future growth of healthcare expenditures. Among other initiatives, quality and value-based benchmarking has become an important field inform clinical evaluation reimbursement questions. The International Consortium for Health Outcomes Measurement (ICHOM) one driving forces translate scientific evidence into standardized assessments that are routinely applicable in day-to-day care settings. These...
Abstract Mesenchymal stem cells (MSCs) represent a very attractive cell source for tissue engineering applications aiming at the generation of artificial bone substitutes. The use three‐dimensional bioprinting technologies has potential to improve classical approach because will allow hydrogel scaffolds with high spatial control MSC allocation within bioprinted construct. In this study, we have performed direct comparisons between commercially available hydrogels in context their...
Abstract This study aimed to analyze the effect of COVID-19 vaccination on occurrence ARDS in hospitalized patients. The population this retrospective, single-center cohort consisted patients with known status and chest computed tomography imaging between July 2021 February 2022. impact was assessed through logistic regression adjusting for demographic differences confounding factors statistical determined using confidence intervals sizes. A total 167 (69% male, average age 58 years, 95% CI...
Abstract Background The Generative Pre-trained Transformer (GPT-4) is a large language model (LLM) trained and fine-tuned on an extensive dataset. After the public release of its predecessor in November 2022, use LLMs has seen significant spike interest, multitude potential cases have been proposed. In parallel, however, important limitations outlined. Particularly, current LLM encounters limitations, especially symbolic representation accessing contemporary data. recent version GPT-4,...
Musculoskeletal conditions are the main drivers of global disease burden and cause significant direct indirect health care costs. Digital applications improve availability access to adequate care. The German system established a pathway for approval "Digitale Gesundheitsanwendungen" (DiGAs; Health Applications) as collectively funded medical services through "Digitale-Versorgung-Gesetz" (Digital Care Act) in 2019.This article presents real-world prescription data collected smartphone-based...
Cardiopulmonary resuscitation is a crucial skill for emergency medical services. As high-risk-low-frequency events pose an immense mental load to providers, concepts of crew resource management, non-technical skills and the science human errors are intended prepare healthcare providers high-pressure situations. However, occur, organizations institutions face challenge providing blame-free error culture achieve continuous improvement by avoiding similar in future. In this case, we report...
Turning during walking and volitionally modulating speed introduces complexity to gait has been minimally explored. How do the spatiotemporal parameters vary between young adults at a normal slower while making 90°, 180°, 360° turns? In laboratory setting, of 10 were documented as they made turns 360°. A generalized linear model was utilized determine effect both turning amplitude. Young reducing their different amplitudes significantly decreased cadence spatial increasing temporal...
Background Germany has one of the oldest social security systems in world. Population coverage subsequently increased, reaching approximately 90% population statutory health insurance (SHI) system today. Before this background, been pioneering integration digital therapeutics (DTx) into its SHI by introduction Digital Healthcare Law (Digitale-Versorgung-Gesetz, DVG) 2019. Thereby, patients became eligible for applications (Digitale Gesundheitsanwendungen, DiGA), which are available upon...
The Broad Consent (BC) by the German Medical Informatics Initiative (MII) was developed to serve as a national blueprint for consenting patients use of routinely collected medical-, insurance- and contact data biomaterials research purposes, ensuring compliance with European General Data Protection Regulation (GDPR). Emergency departments (EDs) are characterized broad unselected patient population that provides opportunity include from different demographic socioeconomic groups, well disease...
Abstract Background: The objective of this study was to investigate the impact COVID-19 vaccination on mortality, intensive care unit (ICU) admissions, and organ protection in hospitalized patients. Methods: This retrospective, single-center cohort included patients with confirmed status chest imaging data from July 2021 February 2022. Outcomes such as ICU admission, damage were evaluated using clinical data, CT scans, laboratory parameters. Our used logistic regression advanced statistical...
The differentiation between patients who require urgent care and those could receive adequate through ambulatory services remains a challenge in managing patient volumes emergency departments (ED). Different approaches were pursued to characterize that safely divert care. However, this characterization challenging as the urgency upon presentation is assessed based on immediately available characteristics of rather than subsequent diagnoses. This work employs core set Ambulatory Care...
Musculoskeletal conditions are among the main contributors to global burden of disease. International guidelines consider patient education and movement exercises as preferred therapeutic option for unspecific degenerative musculoskeletal conditions. Innovative decentralized means required provide access availability such care meet increasing demand this spectrum
Abstract Background COVID-19 vaccination has been shown to prevent and reduce the severity of disease. Aim The aim this study was explore cardioprotective effect in hospitalized patients. Methods In retrospective, single-center cohort study, we included patients with confirmed status from July 2021 February 2022. We assessed outcomes such as acute cardiac events biomarker levels through clinical laboratory data. Results Our analysis covered 167 (69% male, mean age 58 years, 42% being fully...
<sec> <title>BACKGROUND</title> The Generative Pre-trained Transformer (GPT-4) is a large language model (LLM) trained and fine-tuned on an extensive dataset. After the public release of its predecessor in November 2022, use LLMs has seen significant spike interest, multitude potential cases have been proposed. In parallel, however, important limitations outlined. Particularly, current LLM encounters limitations, especially symbolic representation accessing contemporary data. recent version...
Abstract COVID-19 vaccination has been shown to prevent and reduce the severity of disease. The aim this study was explore cardioprotective effect in hospitalized patients. In retrospective, single-center cohort study, we included patients with confirmed status from July 2021 February 2022. We assessed outcomes such as acute cardiac events biomarker levels through clinical laboratory data. Our analysis covered 167 (69% male, mean age 58 years, 42% being fully vaccinated). After adjustment...
Aufgrund der zunehmenden Inzidenz Leberzirrhose 1 in den letzten Jahren stellt die dekompensierte einen häufigen Grund für eine Vorstellung einer Notaufnahme dar. Wegen des breiten Spektrums an möglichen Akutkomplikationen, frühzeitig erkannt und adäquat anbehandelt werden müssen, ist ein strukturiertes Vorgehen erfolgreiche Therapie essenziell.
Maligne Erkrankungen zählen zu den wesentlichen Treibern der globalen Krankheitslast und betreffen insbesondere ältere Patienten. Für die Akut- Notfallversorgung ist es daher wichtig, ein Verständnis des Spektrums möglicher Komplikationen entwickeln einen praktikablen Ansatz zur Versorgung dieser Patienten entwickeln. Dieser Beitrag gibt Überblick über wichtigsten Symptome.
<sec> <title>BACKGROUND</title> Emergency department (ED) routine data represent a unique opportunity for syndromic surveillance both communicable and non-communicable diseases. In 2020 the Robert Koch Institute (RKI) established system, using ED from AKTIN registry. </sec> <title>OBJECTIVE</title> this context, study aims to develop validate syndrome definitions acute coronary (ACS), myocardial infarction (MI), stroke (STR). <title>METHODS</title> First, including diagnosis, chief...