A5051381496- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Mycobacterium research and diagnosis
- Chemotherapy-related skin toxicity
- T-cell and B-cell Immunology
- Methemoglobinemia and Tumor Lysis Syndrome
- Endoplasmic Reticulum Stress and Disease
- Colorectal Cancer Treatments and Studies
- Effects of Radiation Exposure
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Microscopic Colitis
- Pancreatic function and diabetes
- Chronic Lymphocytic Leukemia Research
University of Freiburg
2021-2025
University Medical Center Freiburg
2021-2024
Heidelberg University
2018-2023
University Hospital Heidelberg
2018-2023
University Medical Centre Mannheim
2018
Abstract The treatment of patients with metastatic melanoma immune checkpoint inhibitors (ICI) leads to impressive response rates but primary and secondary resistance ICI reduces progression-free survival. Novel strategies that interfere mechanisms are key further improve patient outcome during therapy. P53 is often inactivated by mouse-double-minute-2 (MDM2), which may decrease immunogenicity cells. We analyzed patient-derived cell lines, performed bulk sequencing analysis samples, used...
Highlights•Drugs currently used against irAEs reduce anti-tumor immunity•ECP induces adiponectin production in inflamed organs while sparing tumor tissue•ECP high response rates patients with ICI-induced irAEsSummaryImmune-related adverse events (irAEs) cancer receiving immune checkpoint inhibitors (ICIs) cause morbidity and necessitate cessation of treatment. Comparing irAE treatments, we find that immunity is preserved mice after extracorporeal photopheresis (ECP) but reduced...
Recent evidence indicates the presence of macrophage subpopulations that express TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis tumor microenvironment. Here, we demonstrate a second subpopulation macrophages expresses rearranged heavy light chain immunoglobulins. We identify immunoglobulin expression human murine monocytes, ex vivo differentiated from microenvironment five randomly selected distinct entities. The chains are expressed small subfraction (~3–5%)...
Maligne Erkrankungen zählen zu den wesentlichen Treibern der globalen Krankheitslast und betreffen insbesondere ältere Patienten. Für die Akut- Notfallversorgung ist es daher wichtig, ein Verständnis des Spektrums möglicher Komplikationen entwickeln einen praktikablen Ansatz zur Versorgung dieser Patienten entwickeln. Dieser Beitrag gibt Überblick über wichtigsten Symptome.
<div>Abstract<p>The treatment of metastatic melanoma patients with immune checkpoint inhibitors (ICI) leads to impressive response rates but primary and secondary resistance ICI reduce progression-free survival. Novel strategies that interfere mechanisms are key further improve patient outcome during therapy. P53 is often inactivated by mouse-double-minute-2 (MDM2), which may decrease immunogenicity cells. We analyzed patient-derived cell lines, performed bulk sequencing analysis...
<p>Supplementary Figures Legends and Methods</p>
<p>Supplementary Figures Legends and Methods</p>
<p>Supplementary Figures Legends and Methods</p>
This report demonstrates a novel class of innate immune cells designated "variable immunoreceptor-expressing myeloids" (VIREMs). Using single-cell transcriptomics and genome-wide epigenetic profiling, we establish that VIREMs are myeloid unrelated to lymphocytes. We visualize the phenotype B-VIREMs capable genetically recombining expressing antibody genes, exclusive hallmark function B These cells, B-VIREMs, display monoclonal cell surface signatures regularly circulate in blood healthy...
<div>Abstract<p>The treatment of metastatic melanoma patients with immune checkpoint inhibitors (ICI) leads to impressive response rates but primary and secondary resistance ICI reduce progression-free survival. Novel strategies that interfere mechanisms are key further improve patient outcome during therapy. P53 is often inactivated by mouse-double-minute-2 (MDM2), which may decrease immunogenicity cells. We analyzed patient-derived cell lines, performed bulk sequencing analysis...
<div>Abstract<p>The treatment of patients with metastatic melanoma immune checkpoint inhibitors (ICI) leads to impressive response rates but primary and secondary resistance ICI reduces progression-free survival. Novel strategies that interfere mechanisms are key further improve patient outcome during therapy. P53 is often inactivated by mouse-double-minute-2 (MDM2), which may decrease immunogenicity cells. We analyzed patient-derived cell lines, performed bulk sequencing...
<p>Supplementary Figures Legends and Methods</p>
<div>Abstract<p>The treatment of patients with metastatic melanoma immune checkpoint inhibitors (ICI) leads to impressive response rates but primary and secondary resistance ICI reduces progression-free survival. Novel strategies that interfere mechanisms are key further improve patient outcome during therapy. P53 is often inactivated by mouse-double-minute-2 (MDM2), which may decrease immunogenicity cells. We analyzed patient-derived cell lines, performed bulk sequencing...
<p>Supplementary Figures Legends and Methods</p>
<p>Supplementary Figures Legends and Methods</p>
Maligne Erkrankungen zählen zu den wesentlichen Treibern der globalen Krankheitslast und betreffen insbesondere ältere Patienten. Für die Akut- Notfallversorgung ist es daher wichtig, ein Verständnis des Spektrums möglicher Komplikationen entwickeln einen praktikablen Ansatz zur Versorgung dieser Patienten entwickeln. Dieser Beitrag gibt Überblick über wichtigsten Symptome.