A5017684782- Immune cells in cancer
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Ubiquitin and proteasome pathways
- Glioma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Clinical practice guidelines implementation
- Geological Modeling and Analysis
- Hungarian Social, Economic and Educational Studies
- Pneumonia and Respiratory Infections
- Musculoskeletal pain and rehabilitation
- Persona Design and Applications
- Psychology, Coaching, and Therapy
- Blood groups and transfusion
- Mobile Health and mHealth Applications
- Blood disorders and treatments
- Pain Management and Placebo Effect
- IL-33, ST2, and ILC Pathways
- 3D Modeling in Geospatial Applications
University Hospital Heidelberg
2010-2023
University Medical Centre Mannheim
2010-2023
Heidelberg University
2010-2023
TU Dresden
2021
Leipzig University
2012
German Cancer Research Center
2009
Zero to Three
2009
Ludwig-Maximilians-Universität München
2003
Macrophages play a central role in host defense against mycobacterial infection and anti- TNF therapy is associated with granuloma disorganization reactivation of tuberculosis humans. Here, we provide evidence for the presence T cell receptor (TCR) αβ based recombinatorial immune subpopulations human mouse monocytes macrophages. In vitro, find that macrophage-TCRαβ induces release CCL2 modulates phagocytosis. blockade suppresses expression. Infection macrophages from healthy individuals...
Recent evidence indicates the presence of macrophage subpopulations that express TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis tumor microenvironment. Here, we demonstrate a second subpopulation macrophages expresses rearranged heavy light chain immunoglobulins. We identify immunoglobulin expression human murine monocytes, ex vivo differentiated from microenvironment five randomly selected distinct entities. The chains are expressed small subfraction (~3–5%)...
Abstract Background Glioblastoma is the most common and malignant brain tumor in adults. usually fatal 12–15 months after diagnosis current possibilities therapy are mostly only palliative. Therefore, new forms of urgently needed. Since tumor‐associated macrophages key players progression survival there large potential investigating their immunological characteristics glioblastoma patients. Recent evidence shows expression variable immunoglobulins TCRαβ subpopulations monocytes, vitro...
Extracellular matrix metalloprotease inducer (EMMPRIN) induces metalloproteinase (MMP) expression, tumor-stroma cell interaction, and invasion/angiogenesis. The objectives of the current study were to find first evidence a prognostic impact total relative EMMPRIN expression in colorectal cancer cells analyze bone marrow-disseminated tumor normal from 2 different gastrointestinal entities.Tumors tissues 40 patients with who followed prospectively (median follow-up, 31 months) analyzed for by...
The increasing availability of healthcare IT has the potential to improve integration health services. Existing projects developing mostly disregard and importance incorporating user feedback proper evaluation measures gain throughout development process. We therefore provide methodological guidance for in a stepwise user-centred design process.Based on literature review we propose adequate methods data collection each phase participatory development. In order an orientation within plethora...
It is the main goal of this study to investigate concordance a decision support system and recommendation spinal surgeons regarding back pain. 111 patients had complete system. Furthermore, their illness was diagnosed by surgeon. The results showed significant medium relation between DSS diagnosis medical doctor. Besides, in almost 50% cases for treatment concordant overestimation occurred more often than underestimation. are discussed "symptom checker" literature claim further evaluations.
Bacterial meningitis is a life-threatening disease that evokes an intense neutrophil-dominated host response to microbes invading the subarachnoid space. Recent evidence indicates existence of combinatorial V(D)J immune receptors in neutrophils are based on T cell receptor (TCR). Here, we investigated expression novel neutrophil TCRαβ-based cerebrospinal fluid (CSF) from human patients with acute-phase bacterial using immunocytochemical, genetic immunoprofiling, biological and mass...
This report demonstrates a novel class of innate immune cells designated "variable immunoreceptor-expressing myeloids" (VIREMs). Using single-cell transcriptomics and genome-wide epigenetic profiling, we establish that VIREMs are myeloid unrelated to lymphocytes. We visualize the phenotype B-VIREMs capable genetically recombining expressing antibody genes, exclusive hallmark function B These cells, B-VIREMs, display monoclonal cell surface signatures regularly circulate in blood healthy...
Abstract Recent findings indicate the presence of T cell receptor (TCR)-based combinatorial immune receptors beyond cells in neutrophils and monocytes/macrophages. In this study, using a semiquantitative trilineage repertoire sequencing approach as well under rigorous bioinformatic conditions, we identify highly complex TCRβ transcriptomes human circulating monocytes that separately encode diversities one two orders magnitude smaller than cells. Intraindividual transcriptomic analyses reveal...
In recent years, a growing body of evidence has shown the presence subpopulation macrophages that express CD3, especially in context mycobacterial infections. Despite these findings, function cells been poorly understood. Furthermore, low frequency CD3+ humans limits study this subpopulation. This work aimed to evaluate expression CD3 murine macrophage cell line and its potential for signaling. The RAW was used at transcriptional protein levels effect vitro infection with Mycobacterium bovis...
Einleitung: Die mechanische Beatmung kann bei Patienten mit Lungenschädigungen zur Überdehnung einzelner Lungenareale führen. Durch Dehnung kommt es in Zellen zu einer Veränderung des Actin-Zytoskeletts. Proteinkinase C (PKC) spielt im Prozess Actin-Rearrangement eine wichtige Rolle. In dieser Studie sollte untersucht werden, ob PKC gesteuerte Veränderungen Zytoskeletts der Dehnungs-induzierten Apoptose assoziiert sind.
Abstract Immunological dogma holds that variable immunoreceptors are restricted to lymphocytes. However, recent studies demonstrate a subpopuation of human neutrophils expresses the TCRαβ (PNAS 103:14441, 2006) and mouse thymic granulocytes exhibit rearrangement their TCR loci (Nature 452:764, 2008). Here, we provide evidence subpopulation circulating monocytes, monocyte-derived macrophages tissue constitutively express TCRαβ-based immunoreceptor. + monocyte/macrophage subpopulations were...