A5073732162- Viral-associated cancers and disorders
- Urticaria and Related Conditions
- Cytomegalovirus and herpesvirus research
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Eosinophilic Disorders and Syndromes
- Herpesvirus Infections and Treatments
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- CRISPR and Genetic Engineering
- Mast cells and histamine
- Parvovirus B19 Infection Studies
- Viral gastroenteritis research and epidemiology
- Cancer-related Molecular Pathways
- Allergic Rhinitis and Sensitization
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
Yale University
2009-2019
University of Colorado Denver
1995-2017
National Jewish Health
1995-2017
Charité - Universitätsmedizin Berlin
2017
Waterbury Hospital
2003-2013
Center for Asthma, Allergy and Respiratory Disease
2013
Denver School of Nursing
1995
Albert Einstein College of Medicine
1991-1992
The authors propose that this evidence supports the role of a previously unknown herpesvirus as an infectious agent associated with KS.
Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, suggesting dysregulation the innate immune response autoimmunity. In this study, we investigated whether lytic form Epstein-Barr virus (EBV) infection (infectious EBV) is present scleroderma monocytes contributes to their activation SSc. Monocytes were isolated from peripheral blood...
Herpes simplex virus 1 (HSV-1) ICP8 is a single-stranded DNA-binding protein that necessary for viral DNA replication and exhibits recombinase activity in vitro. Alignment of the HSV-1 amino acid sequence with homologs from other herpesviruses revealed conserved aspartic (D) glutamic (E) residues. Amino residue D1087 was every homolog analyzed, indicating it likely critical function. We took genetic approach to investigate functions D E residues replication. The E1086A D1087A mutant form...
The catalytic site of the HIV integrase is contained within an RNase H-like fold, and numerous drugs have been developed that bind to this inhibit its activity. Herpes simplex virus (HSV) encodes two proteins with potential folds, infected cell protein 8 (ICP8) DNA-binding protein, which necessary for viral DNA replication exhibits recombinase activity in vitro, terminase, essential cleavage packaging. Therefore, we hypothesized inhibitors might also HSV by targeting ICP8 and/or terminase....
A 40-yr-old Hispanic man presented to NJCIRM with end-stage lung disease. Evaluation of this patient 10 yr earlier noted bronchiectasis, normal sweat electrolytes, pancreatic sufficiency, delayed progression pulmonary disease, and a sperm biopsy consistent fertility. At the time admission bronchiectasis was extensive. DNA testing demonstrated homozygosity for 3849+10kb C > T cystic fibrosis (CF) allele. This is first description homozygous expression allele in male patient. Confirmation...
In this work we present evidence that the p53 tumor suppressor protein and NF-kappaB transcription factors could be related through common descent from a family of ancestral regulating cellular proliferation apoptosis. P53 is homotetrameric factor known to interact with ankyrin 53BP2 (a fragment ASPP2 protein). also regulated by proteins, prototype which IkappaB family. The DNA binding sequences two are similar, sharing 8 out 10 nucleotides. Interactions between both direct indirect, have...
Background The RAG encoded proteins, RAG-1 and RAG-2 regulate site-specific recombination events in somatic immune B- T-lymphocytes to generate the acquired repertoire. Catalytic activities of proteins are related recombinase functions a pre-existing mobile DNA element DDE recombinase/RNAse H family, sometimes termed “RAG transposon”. Methodology/Principal Findings Novel this work is suggestion that responsible for origins immunity was by primordial herpes virus, rather than transposon.” A...
A family of transposon-like sequences in the C. elegans genome is described. This family, termed Tc6 consists mostly conserved, 1.6 kb elements. Four elements or partial have been cloned and DNA three were determined. One appears to be a complete element 1603 nucleotides, consisting palindrome 765 with central, non-palindromic region 73 nucleotides. Another has an identical structure except for intemal deletion. third terminating at probable internal restriction site used cloning. fourth...
Abstract We have previously shown that the EBV ZEBRA protein (also denoted EB1, Z, or Zta) encoded by BZLF open reading frame is expressed in primary human thymocytes and T lymphoblastoid cell lines infected EBV. Expression of EBV-encoded gene products lymphocytes could contribute to viral pathogenesis during acute infection as well individuals coinfected with HIV. HPB-ALL Jurkat transiently stably expressing were characterized this work. cells was associated decreased expression an NF-κB...
The carboxyl terminal of Epstein-Barr virus (EBV) ZEBRA protein (also termed BZLF-1 encoded replication Zta or ZEBRA) binds to both NF-κB and p53. authors have previously suggested that this interaction results from an ankyrin-like region the since ankyrin proteins such as IκB interact with p53 proteins. These interactions may play a role in immunopathology viral carcinogenesis B lymphocytes well other cell types transiently infected by EBV T lymphocytes, macrophages epithelial cells....