A5031782020- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Oral health in cancer treatment
- Medical Imaging Techniques and Applications
- Oral Health Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Colorectal and Anal Carcinomas
- Ear and Head Tumors
- Endometrial and Cervical Cancer Treatments
- Peptidase Inhibition and Analysis
- Hepatitis B Virus Studies
- Cancer survivorship and care
- RNA modifications and cancer
- Bone and Joint Diseases
Linkou Chang Gung Memorial Hospital
2016-2025
Chang Gung University
2016-2025
Chang Gung Memorial Hospital
2015-2025
Jeju International University
2025
University of California, Irvine
2024
Yale University
1998-2024
Texas Tech University
2024
Riverside Community Hospital
2024
Texas Tech University Health Sciences Center
2024
National Taiwan University
2019-2024
Purpose To assess the clinical usefulness of [ 18 F]fluorodeoxyglucose positron emission tomography ([ F]FDG PET) as well computed (CT) or magnetic resonance imaging (MRI) in oral squamous cell carcinoma (SCC) patients with palpably negative neck. Patients and Methods In total, 134 SCC neck were prospectively evaluated PET, CT/MRI, their visual correlation. Histopathologic analysis was used gold standard for assessment these techniques. Results Thirty-five (26.1%) our found to have...
Objective: The growth of the biomedical literature presents special challenges for both human readers and automatic algorithms. One such challenge derives from common uncontrolled use abbreviations in literature. Each additional abbreviation increases effective size vocabulary a field. Therefore, to create an automatically generated maintained lexicon abbreviations, we have developed algorithm match text with their expansions. Design: Our method uses statistical learning algorithm, logistic...
The miRNA participates in a variety of biologic processes, and dysregulation is associated with malignant transformation. In this study, we determined specific profile oral cancer by using array screening method. There were 23 miRNAs found considerably differential expressions between six cell lines five normal keratinocytes, which, 10 showed the highest significant difference after independent examination reverse transcription quantitative PCR. Eight molecules upregulated, miR-10b,...
Persistently elevated posttreatment plasma EBV DNA is a robust predictor of relapse in nasopharyngeal carcinoma (NPC). However, assay standardization necessary for use biomarker-driven trials. We conducted study to harmonize the method between four centers with expertise quantitation.Plasma samples 40 patients NPC were distributed centers. was extracted and copy number determined by real-time quantitative PCR (BamHI-W primer/probe). Centers used same protocol but generated their own...
Previous studies have shown that total lesion glycolysis (TLG) may serve as a prognostic indicator in oropharyngeal squamous cell carcinoma (OPSCC). We sought to investigate whether the textural features of pretreatment (18)F-FDG PET/CT images can provide any additional information over TLG and clinical staging patients with advanced T-stage OPSCC.We retrospectively analyzed 70 OPSCC who had completed concurrent chemoradiotherapy, bioradiotherapy, or radiotherapy curative intent. All data on...
Concurrent chemoradiotherapy (CCRT) is superior to radiotherapy alone for treating locoregionally advanced nasopharyngeal carcinoma (NPC). Whether adding induction chemotherapy (IC) further improves the outcome warrants investigation.This open-label multicenter phase III trial was conducted at 11 institutions in Taiwan. Patients with stage IVA or IVB NPC were randomized receive IC followed by CCRT (I-CCRT) alone. I-CCRT arm received three cycles of mitomycin C, epirubicin, cisplatin, and...
Tumor cell fusion with motile bone marrow-derived cells (BMDCs) has long been posited as a mechanism for cancer metastasis. While there is much support this from culture and animal studies, it yet to be confirmed in human cancer, tumor the same patient cannot easily distinguished genetically.We carried out genotyping of metastatic melanoma brain that arose following allogeneic bone-marrow transplantation (BMT), using forensic short tandem repeat (STR) length-polymorphisms distinguish donor...
PURPOSE: To compare the efficacy of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy with that radiotherapy (R/T) for bulky early-stage cervical cancer. PATIENTS AND METHODS: Women previously untreated (primary tumor ≥ 4 cm) stage IB or IIA non–small-cell carcinoma uterine cervix were randomly assigned to receive either cisplatin 50 mg/m 2 and vincristine 1 day bleomycin 25 3 days three cycles (NAC arm) primary pelvic only (R/T arm). The ratio patient allocation was 6:4 NAC...
Abstract Background: There is no plasma marker for detecting oral cancer, one of the most frequent cancers worldwide. We developed a bead-based affinity-fractionated proteomic method to discover novel cancer. Methods: Affinity purification heparinized with magnetic beads and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis were used screen potential cancer markers. compiled MS protein profiles 57 patients compared them from 29 healthy...
ChIP sequencing (ChIP-seq) is a new method for genomewide mapping of protein binding sites on DNA. It has generated much excitement in functional genomics. To score data and determine adequate depth, both the genomic background must be properly modeled. develop computational foundation to tackle these issues, we first performed study characterize observed statistical nature this type high-throughput data. By linking sequence tags into clusters, show that there are two components distribution...
With the increased use of radiotherapy in treatment head and neck cancers, free tissue transfer an irradiated field is now common. Reported outcomes with reconstructions areas are often unclear contradictory. This attributable part to small sample size heterogeneity patients procedures. The goals this study were, first, determine outcome using a large retrospective cohort and, second, identify negative predictors that could potentially be modified reduce morbidity these procedures.Patients...
MicroRNA-196 (miR-196), which is highly up-regulated in oral cancer cells, has been reported to be aberrantly expressed several cancers; however, the significance of miR-196 not yet addressed. Cellular functions response modulation were examined, including cell growth, migration, invasion and radio/chemosensitivity. Algorithm-based studies used identify regulatory target miR-196. The gene downstream molecular mechanisms confirmed by RT-qPCR, western blot, luciferase reporter confocal...