A5079418374- Mast cells and histamine
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Drug-Induced Adverse Reactions
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Contact Dermatitis and Allergies
- Respiratory and Cough-Related Research
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Acute Myeloid Leukemia Research
- Polyamine Metabolism and Applications
- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Blood disorders and treatments
- Genetic Syndromes and Imprinting
- Chemotherapy-related skin toxicity
Cleveland Clinic
2012-2024
Cleveland Clinic Lerner College of Medicine
2010-2016
University of Mississippi Medical Center
2001-2016
University of Mississippi
2015
Giorgio Cini Foundation
2014
Istituto Tecnico Industriale Alessandro Volta
2014
Los Angeles City College
2014
Azienda USL di Pescara
2013
Gilead Sciences (United States)
2013
University of Nebraska Medical Center
2007
Human mast cells (hMCs) derived in vitro from cord blood mononuclear exhibit stem cell factor (SCF)-dependent comitogenic responses to T helper type 2 (Th2) cytokines. As cysteinyl leukotriene (cys-LT) biosynthesis is a characteristic of immunoglobulin (Ig)E-activated mucosal hMCs, we speculated that Th2 cytokines might regulate eicosanoid generation by hMCs. After passive sensitization for 5 d with IgE the presence SCF, anti-IgE–stimulated hMCs elaborated minimal cys-LT (0.1 ± 0.1 ng/106...
We hypothesized that analysis of single nucleotide polymorphism arrays (SNP-A) and new molecular defects may provide insight in the pathogenesis systemic mastocytosis (SM). SNP-A karyotyping was applied to identify recurrent areas loss heterozygosity bidirectional sequencing performed evaluate mutational status TET2, DNMT3A, ASXL1, EZH2, IDH1/IDH2 CBL gene family. Overall survival (OS) analyzed using Kaplan-Meier method. studied a total 26 patients with SM. In 67% SM patients, showed...
Mast cells (MC) are stem cell factor-dependent tissue-based hematopoietic with substantial functional heterogeneity. Cord blood-derived human MC (hMC) express receptors for IL-5, and IL-5 mediates comitogenesis of hMC in vitro . Although is not required normal development, we considered that it might prime their high-affinity Fc receptor IgE (FcɛRI)-dependent generation cytokines, as previously demonstrated IL-4. Compared maintained factor alone, primed expressed 2- to 4-fold higher...
A proliferation of mast cells around the small pulmonary blood vessels and alveolar septae has been noted in models hypertension, plexiform lesions arterial hypertension (PAH) patients. Here, we hypothesize that total cell numbers activation are increased PAH they contribute to vascular remodeling through cellular soluble proangiogenic effectors. To test this, urine were collected from patients with (N=44), asthma (N=18) healthy controls (N=29) quantitate biomarkers body (total mature...
Mast cells (MCs) are found in increased numbers at airway mucosal surfaces asthmatic patients. Because human epithelial (HAECs) actively participate inflammatory responses and direct contact with MCs the mucosa, we hypothesized that HAEC-MC interactions may contribute to differentiation survival of mucosa. Here, show HAECs express mRNA protein for soluble membrane-bound stem cell factor, releasing factor into culture supernatant a concentration 5.9 ± 0.1 ng per 10 6 HAEC. were able support...
Summary Systemic mastocytosis (SM) is characterized by the abnormal proliferation and accumulation of mast cells (MCs). Constitutive activation kit, a receptor tyrosine kinase (TK), has been associated with all types SM. Signal transducers activators transcription (STATs), such as STAT5, mediate downstream kit signalling. We hypothesized that nuclear phospho‐STAT5 (pSTAT5) in MCs might reflect TK would be marker Expression tryptase, CD25, CD2 pSTAT5 was evaluated immunohistochemistry (IHC)...
Melas (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) is one of a group heterogeneous yet clinically distinct syndromes ascribed to defect in mitochondrial function. Here, the case patient diagnosed MELAS syndrome who subsequently developed acute renal failure reported. Although no clear insult was evident at time, clinical picture consistent diagnosis tubular necrosis. The patient's function returned baseline. This article reviews literature concerning...
The burden of mast cell (MC) infiltration and their phenotypes, MC-tryptase (MCT ) MC-tryptase/chymase (MCTC ), after lung transplantation (LT) has not been evaluated in human studies.We reviewed 20 transbronchial biopsy (TBLB) specimen from patients with early normal allograft (<6 months post-LT, n=5), late (>6 months, A2 or worse acute cellular rejection (ACR, chronic dysfunction (CLAD, n=5). Slides were immunostained for tryptase chymase. Total MC, MCT , MCTC to-MCT ratio compared between...