A5025336294- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Clinical practice guidelines implementation
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Health and Mental Health
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Cardiac tumors and thrombi
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chronic Disease Management Strategies
- Meningioma and schwannoma management
- Blood Pressure and Hypertension Studies
- RNA regulation and disease
- Inflammasome and immune disorders
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Immune Response and Inflammation
Klinikum Ludwigshafen
2020-2024
John Hunter Hospital
2020
University Medical Centre Mannheim
2015-2019
Heidelberg University
2012-2019
University Hospital Heidelberg
2015-2019
Klinikum Stuttgart
2015
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2012
University Hospital Cologne
2012
The importance of cancer-associated hypercoagulability as a possible stroke etiology in patients with cancer has received relatively little attention to date. A recent study suggested that hypercoagulation may be special the absence conventional mechanisms.We identified ischemic sequentially admitted our center additional diagnosis active and malignant from 2002 2011. By using prospectively collected stroke, MRI, laboratory data banks, risk factors types cancer, deep vein...
<b><i>Background:</i></b> Due to the lack of specific diagnostic markers, diagnosis cancer-related stroke strongly depends on its phenotype. Distinct DWI lesion patterns with involvement multiple vascular territories have been reported repeatedly in but not addressed detail a selected cohort prospectively recruited cancer patients emphasis hypercoagulable conditions. <b><i>Patients and Methods:</i></b> Ischemic known malignant activity,...
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and associated with impaired health-related quality of life (HRQoL), high symptom severity, poor cardiovascular outcomes. Both clinical psychological factors may contribute to severity HRQoL in AF. Methods: Using data from observational Fibrillation Rhine-Neckar Region (ARENA) trial, we identified medical psychosocial AF-related using European Heart Rhythm Association classification 5-level EuroQoL- 5D....
Background and Purpose- Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated relative [FLAIR-rSI]) magnetic resonance imaging is associated with time elapsed since onset higher intensities signifying longer intervals. In the randomized controlled WAKE-UP trial (Efficacy Safety MRI-Based Thrombolysis Wake-Up Stroke Trial), intravenous alteplase was effective patients unknown selected by visual assessment diffusion weighted...
Previous studies showed insufficient control of cardiovascular risk factors (CVRF) and high stroke recurrence rates among ischemic patients in Germany. Currently, no structured secondary prevention program exists clinical routine. We present the trial design pilot phase results a complex intervention to improve care after hospital discharge Germany.SANO is cluster-randomized with 30 participating regions across Germany aiming enrol 2,790 (drks.de, DRKS00015322). Study combines both...
Regional deprivation has been shown to be an influential factor in stroke incidence risk. However, there is a paucity of knowledge on regional differences and mortality Germany.We assessed data from the Diagnosis Related Groups statistics (2016-2019) German Federal Registry Physicians (2019). Negative binomial regression analysis was used examine association between Index Multiple Deprivation 2015 covering 401 districts district-free cities Germany incidence, treatment, mortality.The...
Background: The safety of systemic thrombolysis in patients with intracranial tumor and cavernoma are unknown. So far evidence is limited to a number case reports few series or unspecified data based on population-based analysis. Our aim was comprehend the risk these patients. Methods: Patients additional who received IV tissue plasminogen activator (t-PA) treatment at our comprehensive stroke center over period 7 years were identified database compared same matched control subjects without...
To describe a patient with cryopyrin-associated periodic syndrome (CAPS) an uncommon neurologic phenotype and rare underlying genetic mutation.Our had CAPS NLPR3 missense mutation (p.Tyr859Cys) in exon 6 chorea as the major symptom. Clinical symptoms were associated persistent inflammatory changes of CSF serum included elevated anticardiolipin immunoglobulin G; MRI showed prolonged gadolinium enhancement 2 chronic lesions. Conventional immunosuppressive treatment prednisolone...
Bacterial meningitis is a life-threatening disease that evokes an intense neutrophil-dominated host response to microbes invading the subarachnoid space. Recent evidence indicates existence of combinatorial V(D)J immune receptors in neutrophils are based on T cell receptor (TCR). Here, we investigated expression novel neutrophil TCRαβ-based cerebrospinal fluid (CSF) from human patients with acute-phase bacterial using immunocytochemical, genetic immunoprofiling, biological and mass...
Abstract Background Previous research suggests that regional deprivation significantly influences the risk of stroke. However, little is known about differences in stroke incidence and mortality within Germany. Methods We utilized data from Diagnosis Related Groups statistics (2016-2019) German Federal Register Physicians (2019). used negative binomial regression analysis to investigate relationship between Index Multiple Deprivation 2015, covering 401 districts district-free cities Germany,...
Atrial fibrillation (AF) is a major cause of stroke. An individual risk estimation remains challenging, as AF patients with and without cerebrovascular event (CVE) may differ in yet unknown factors beyond those covered by the CHA
ABSTRACT Background Asymptomatic nonvalvular atrial fibrillation is often suspected in patients with cryptogenic stroke which constitute 20%–30% of ischemic strokes. Detection (AF) and treatment anticoagulation can reduce the risk stroke. We sought to investigate prevalence asymptomatic (aAF) a history or an acute on admission. Methods From November 2011 until December 2014, 15,308 first episode AF were enrolled phase 2 international, prospective, multicenter global registry long‐term oral...
Improving understanding of study contents and procedures might enhance recruitment into studies retention during follow-up. However, data in stroke patients on the informed consent (IC) procedure are sparse.We conducted a cross-sectional among ischemic taking part IC an ongoing cluster-randomized secondary prevention trial. All aspects were assessed interview using standardized 20-item questionnaire. Responses collected within 72 h after analyzed quantitatively qualitatively. Participants...