A5015137135- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Issues in Pregnancy
- Neurosurgical Procedures and Complications
- Patient Safety and Medication Errors
- Cardiac tumors and thrombi
- Central Venous Catheters and Hemodialysis
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Intracerebral and Subarachnoid Hemorrhage Research
University Medical Centre Mannheim
2016-2025
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
German Centre for Cardiovascular Research
2016-2024
Medizinische Fakultät Mannheim
2019-2024
Recent studies have highlighted that takotsubo syndrome (TTS) is associated with a poor clinical outcome. Our study was conducted to determine the short- and long-term prevalence, recurrence rate impact of life-threatening arrhythmias (LTA) on outcome TTS. institutional database constituted collective 114 patients diagnosed TTS between 2003 2015. The patient groups, divided according presence (n = 13, 11.4%) or absence 101, 88.6%) LTAs, were followed-up over period 3 years so as analyses...
Previous studies revealed that patients with Takotsubo cardiomyopathy (TTC) have a higher mortality rate than the general population. Supraventricular tachycardia is well-known complication of TTC. This study was performed to determine short- and long-term prognostic impact atrial fibrillation associated TTC patients. Our institutional database constituted collective 114 diagnosed from 2003 2015. The were divided into two groups according presence (n = 21, 18.4%) or absence 93, 81.5%)...
Recent hypotheses have suggested the pathophysiological role of catecholamines in evolution Takotsubo syndrome (TTS). The extent cardiac and circulatory compromise dictates use some form supportive therapy. This study was designed to investigate clinical outcomes associated with catecholamine TTS patients. Our institutional database constituted a collective 114 patients diagnosed between 2003 2015. study-patients were subsequently classified into two groups based on need for support during...
Abstract Background Interventional left atrial appendage occlusion (LAAO) mitigates the risk of thromboembolic events in nonvalvular fibrillation (AF) patients with contraindication for long-term oral anticoagulation (OAC). Patients prior stroke have a relevantly increased recurrent stroke, so effectiveness LAAO could be reduced this specific very high-risk patient group. Aim This sub-study LAARGE registry investigates and safety secondary prevention AF history stroke. Methods is...
Elevated cardiac troponin (cTn) levels (representing myocardial injury) are frequently found in patients with spontaneous intracerebral hemorrhage (sICH). Overall, the relationship between sICH and elevated cTn is not well understood. The aim of this study was to investigate patient characteristics clinical parameters injury. This a retrospective observational based on Mannheim Stroke database. Consecutive cases acute symptomatic available high-sensitivity I (hs-cTnI) at hospital admission...
Several acute complications related to takotsubo cardiomyopathy (TTC) have been documented recently. However, the incidence and clinical significance of thromboembolic events in TTC is not well established.A detailed investigation characteristics in-hospital 114 consecutive patients diagnosed with between January 2003 September 2015 was carried out. This study initiated reveal predictors, significance, short-term long-term outcomes associated on index presentation.The around 12.2%, these...
A standardized imaging proposal evaluating implanted left atrial appendage (LAA) occlusion devices by cardiac computed tomography angiography (cCTA) has never been investigated.cCTA datasets were acquired on a 3(rd) generation dual-source CT system and reconstructed with slice thickness of 0.5 mm. An interdisciplinary evaluation was performed two interventional cardiologists one radiologist 3D multi-planar workstation. reconstruction algorithm developed in order to assess relevant clinical...
The level of Galectin-3 (Gal-3) protein purportedly reflects an ongoing cardiac fibrotic process and has been associated with ventricular remodeling, which is instrumental in the development heart failure preserved ejection fraction (HFpEF) syndrome. aim this study was to investigate potential use Gal-3 improved characterization grades diastolic dysfunction as defined by echocardiography.Seventy HFpEF patients undergoing routine echocardiography were prospectively enrolled present...
Abstract Objectives Chronic kidney disease (CKD) is associated with an increased complication rate after cardiac interventions. Although CKD has a high prevalence among atrial fibrillation patients, the impact of on periprocedural complications and outcome interventional left appendage closure (LAAC) unclear. The present study, therefore, aimed to investigate whether influences procedure’s effectiveness safety. Methods LAARGE prospective, non-randomised registry. LAAC was conducted different...
Recurrence of takotsubo cardiomyopathy (TTC) is a well-known complication. However, current literature lists only few isolated cases. We aimed to determine the incidence and clinical significance recurrent TTC.Our institutional database constituted collective 114 patients diagnosed with TTC since 2003. Close follow-up these revealed recurrence in seven (6.1%). The time interval between index event its varied six months years. Arterial hypertension was more group compared non-recurrence...
Takotsubo cardiomyopathy (TTC) is a relevant differential diagnosis in patients presenting with signs of an acute coronary syndrome. Although recent literature has highlighted some salient features this disorder, there been little information elucidating the differences clinical features, electrocardiographic findings, echocardiographic data and TTC-related complications associated different variants TTC.Our institutional database constituted collective 114 diagnosed TTC between 2003 2015...
A standardized imaging algorithm by cardiac computed tomography angiography (cCTA) (LOVE-view) was used in 30 patients to evaluate the influence of different left atrial appendage (LAA) morphologies on development thrombosis LAA 6 months after implantation an occlusion device (Watchman or Amplatzer-Cardiac-Plug) with non-valvular fibrillation, CHA2DS2-VASc-Score >1 and a contraindication for oral anticoagulation. The distribution 40% windsock, 17% broccoli 43% chicken wing type. There no...
The interventional left atrial appendage closure (LAAC) is a guideline-conform alternative to oral anticoagulation (OAC) in non-valvular fibrillation patients with OAC ineligibility. It was aimed directly compare two contemporary devices real-world patient population. LAAC conducted centres between 2010 and 2014 as well 2017, respectively, standard fashion based on the specific manufacturer's recommendations. Baseline characteristics, procedural data event rates during intra-hospital 6...
Previous studies revealed that patients with Takotsubo cardiomyopathy (TTC) have a higher mortality rate than the general population. It is still unclear whether sex differences may influence long-term prognosis of TTC patients. The purpose this study was to determine do short- and outcomes TTC.A total 114 were admitted University Medical Centre Mannheim from January 2003 September 2015 entered into database Mannheim, retrospectively analyzed. Patients diagnosed by Mayo Clinic criteria....
Interventional left atrial appendage closure (LAAC) is an emerging alternative to oral anticoagulation (OAC) for stroke prevention in fibrillation (AF) concomitance with a contraindication standard OAC. This sub-analysis of the LAARGE registry aimed investigate differences between different LAA morphologies real-world setting.This prospective, multicentre, observational included 562 patients from 37 centres ineligibility long-term OAC April 2014 and January 2016. Baseline characteristics,...
Background: While coronary artery bypass grafting remains the standard treatment of complex multivessel disease, advent peripheral ventricular assist devices has enhanced safety percutaneous intervention. We therefore evaluated in terms inhospital outcome comparing protected high-risk intervention with Impella 2.5 device and patients disease. Methods: This retrospective study included disease (SYNTAX score >22) undergoing either before implementation a programme or following start...