A5008534875- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Gene Regulatory Network Analysis
- Medical Imaging Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Bacterial Genetics and Biotechnology
- Systemic Lupus Erythematosus Research
- Viral Infectious Diseases and Gene Expression in Insects
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Polyomavirus and related diseases
- RNA regulation and disease
Rigshospitalet
2022-2024
Copenhagen University Hospital
2022-2024
University of Copenhagen
2022-2024
University of Oxford
2017
University of Southern Denmark
2014
Abstract Reduced cerebrovascular response to neuronal activation is observed in patients with neurodegenerative disease. In the present study, we examined correlation between reduced visual (ΔCBF Vis.Act ) and subclinical cognitive deficits a human population of mid-sixties individuals without Such would suggest that impaired function occurs before overt A total 187 subjects (age 64–67 years) Metropolit Danish Male Birth Cohort participated study. ΔCBF was measured using arterial spin...
Abstract The microtubule-associated protein tau is implicated in various neurodegenerative diseases including Alzheimer’s disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. Mutations the gene MAPT cause frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). In human central nervous system, six isoforms expressed, imbalances isoform ratios associated pathology. To date,...
In relapsing-remitting multiple sclerosis (RRMS), early disease control reduces the risk of permanent disability. The blood-brain barrier (BBB) is compromised in MS, and its permeability a potential biomarker.To investigate BBB measured by MRI as marker alemtuzumab efficacy.Patients with RRMS initiating treatment were recruited prospectively. was assessed Patlak-derived influx constant (Ki) dynamic contrast-enhanced before 6, 12, 18 months after first course alemtuzumab. No Evidence Disease...
Cerebral oxygen metabolism is altered in relapsing-remitting multiple sclerosis (RRMS), possibly a result of disease related cerebral atrophy with subsequent decreased demand. However, MS inflammation can also inhibit brain metabolism. Therefore, we measured blood flow (CBF) and metabolic rate (CMRO2) using MRI phase contrast mapping susceptibility-based oximetry 44 patients early RRMS 36 healthy controls. white matter lesion load were assessed from high-resolution structural MRI. Expanded...
Background Dynamic contrast‐enhanced MRI (DCE‐MRI) has seen increasing use for quantification of low level blood–brain barrier (BBB) leakage in various pathological disease states and correlations with clinical outcomes. However, currently there exists limited studies on reproducibility healthy controls, which is important the establishment a normality threshold future research. Purpose To investigate DCE‐MRI to evaluate effect arterial input function (AIF) selection manual region interests...
Studies on the capability of cerebrospinal fluid neurofilament light chain (cNfL) to predict multiple sclerosis (MS) conversion in clinically isolated syndromes have yielded varying results.
The lac promoter is one of the most commonly used promoters for expression control recombinant genes in E. coli. In absence galactosides, repressed by its repressor protein LacI. Since regulated a repressor, overexpression LacI necessary regulation when introduced on high-copy plasmid. For that purpose, modified variant LacI, LVA-tagged was submitted to Registry Standard Biological Parts and has been more than 500 constructs since then. We have found, however, natural superior as controller...